Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children

  • Alexander W Kay
  • , Lucia González Fernández
  • , Yemisi Takwoingi
  • , Michael Eisenhut
  • , Ryan D Vu
  • , Karen Steingart
  • , Anne K Detjen
  • , Anna M Mandalakas

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:

Primary objectives

To determine the diagnostic accuracy of Xpert MTB/RIF and Xpert Ultra for a) PTB in children presumed to have tuberculosis; b) lymph node tuberculosis in children presumed to have tuberculosis; c) tuberculous meningitis in children presumed to have tuberculosis; and d) rifampicin resistance in children presumed to have tuberculosis.

For tuberculosis detection, the role of the index tests would be a replacement for standard practice.

For rifampicin resistance detection, the role of the index tests would be an initial replacement test for culture‐based drug susceptibility testing.

Original languageEnglish
Article numberCD013359
Pages (from-to)CD013359
JournalCochrane Database of Systematic Reviews
Volume2019
Issue number6
Early online date17 Jun 2019
DOIs
Publication statusPublished - 17 Jun 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Fingerprint

Dive into the research topics of 'Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children'. Together they form a unique fingerprint.

Cite this