Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children

Alexander W Kay; Lucia González Fernández; Yemisi Takwoingi; Michael Eisenhut; Ryan D Vu; Karen Steingart; Anne K Detjen; Anna M Mandalakas

doi:10.1002/14651858.cd013359

Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children

Alexander W Kay, Lucia González Fernández, Yemisi Takwoingi, Michael Eisenhut, Ryan D Vu, Karen Steingart, Anne K Detjen, Anna M Mandalakas

Clinical Sciences

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:

Primary objectives

To determine the diagnostic accuracy of Xpert MTB/RIF and Xpert Ultra for a) PTB in children presumed to have tuberculosis; b) lymph node tuberculosis in children presumed to have tuberculosis; c) tuberculous meningitis in children presumed to have tuberculosis; and d) rifampicin resistance in children presumed to have tuberculosis.

For tuberculosis detection, the role of the index tests would be a replacement for standard practice.

For rifampicin resistance detection, the role of the index tests would be an initial replacement test for culture‐based drug susceptibility testing.

Original language	English
Article number	CD013359
Pages (from-to)	CD013359
Journal	Cochrane Database of Systematic Reviews
Volume	2019
Issue number	6
Early online date	17 Jun 2019
DOIs	https://doi.org/10.1002/14651858.cd013359
Publication status	Published - 17 Jun 2019

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/14651858.cd013359

Kay et al-2019-Cochrane Database of Systematic ReviewsFinal published version, 518 KB

Cite this

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AU - González Fernández, Lucia

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AU - Eisenhut, Michael

AU - Vu, Ryan D

AU - Steingart, Karen

AU - Detjen, Anne K

AU - Mandalakas, Anna M

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Xpert MTB/RIF and Xpert MTB/RIF Ultra assays for active tuberculosis and rifampicin resistance in children

Abstract

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