WHO global research priorities for antimicrobial resistance in human health

Silvia Bertagnolio; Zlatina Dobreva; Chad M. Centner; Ioana Diana Olaru; Daniele Donà; Stefano Burzo; Benedikt D. Huttner; Antoine Chaillon; Nebiat Gebreselassie; Teodora Wi; Mateusz Hasso-Agopsowicz; Benedetta Allegranzi; Hatim Sati; Verica Ivanovska; Kavita U. Kothari; Hanan H. Balkhy; Alessandro Cassini; Raph L. Hamers; Kitty Van Weezenbeek; David Aanensen; Alexandre Alanio; Ana Alastruey-Izquierdo; Tinsae Alemayehu; Majdi Al-Hasan; Karel Allegaert; Amal Saif Al-Maani; Jameela Al-Salman; Abeer Nizar Alshukairi; Afreenish Amir; Tanya Applegate; George F. Araj; Marlen Arce Villalobos; Christine Årdal; Diane Ashiru-Oredope; Elizabeth A. Ashley; François Xavier Babin; Laura H. Bachmann; Till Bachmann; Kate Susan Baker; Manica Balasegaram; Colleen Bamford; Fernando Baquero; Laura Isabel Barcelona; Quique Bassat; Matteo Bassetti; Sulagna Basu; Justin Beardsley; Grey Benoit Vásquez; Nick Feasey; Christopher Parry

doi:10.1016/s2666-5247(24)00134-4

WHO global research priorities for antimicrobial resistance in human health

Silvia Bertagnolio
, Zlatina Dobreva
, Chad M. Centner
, Ioana Diana Olaru
, Daniele Donà
, Stefano Burzo
, Benedikt D. Huttner
, Antoine Chaillon
, Nebiat Gebreselassie
, Teodora Wi
, Mateusz Hasso-Agopsowicz
, Benedetta Allegranzi
, Hatim Sati
, Verica Ivanovska
, Kavita U. Kothari
, Hanan H. Balkhy
, Alessandro Cassini
, Raph L. Hamers
, Kitty Van Weezenbeek
, David Aanensen

Alexandre Alanio, Ana Alastruey-Izquierdo, Tinsae Alemayehu, Majdi Al-Hasan, Karel Allegaert, Amal Saif Al-Maani, Jameela Al-Salman, Abeer Nizar Alshukairi, Afreenish Amir, Tanya Applegate, George F. Araj, Marlen Arce Villalobos, Christine Årdal, Diane Ashiru-Oredope, Elizabeth A. Ashley, François Xavier Babin, Laura H. Bachmann, Till Bachmann, Kate Susan Baker, Manica Balasegaram, Colleen Bamford, Fernando Baquero, Laura Isabel Barcelona, Quique Bassat, Matteo Bassetti, Sulagna Basu, Justin Beardsley, Grey Benoit Vásquez, Nick Feasey, Christopher Parry

World Health Organization
London School of Hygiene and Tropical Medicine
University of Münster
University of Padua
WHO Japan
Canton of Vaud
University of Lausanne
Universitas Indonesia
University of Oxford
Université Paris Cité
Instituto de Salud Carlos III
St. Paul‘s Hospital Millennium Medical College
University of South Carolina
KU Leuven
Ministry of Health, Oman
Ministry of Health, Kingdom of Bahrain
Alfaisal University
Ministry of National Health Services, Regulations and Coordination
University of New South Wales
American University of Beirut
Ministerio de Salud
Norwegian Institute of Public Health
UK Health Security Agency
Fondation Merieux
Centers for Disease Control and Prevention
University of Edinburgh
University of Cambridge
Global Antibiotic Research & Development Partnership
Pathcare
Ministerio de Salud
Universitat de Barcelona
University of Genoa
National Institute of Cholera and Enteric Diseases India
University of Sydney
Ministerio de Salud Pública y Asistencia Social
University of St Andrews

Research output: Contribution to journal › Review article › peer-review

190 Citations (Scopus)

Abstract

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

Original language	English
Article number	100902
Journal	The Lancet Microbe
Volume	5
Issue number	11
Early online date	13 Aug 2024
DOIs	https://doi.org/10.1016/s2666-5247(24)00134-4
Publication status	Published - 7 Nov 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Bertagnolio, S., Dobreva, Z., Centner, C. M., Olaru, I. D., Donà, D., Burzo, S., Huttner, B. D., Chaillon, A., Gebreselassie, N., Wi, T., Hasso-Agopsowicz, M., Allegranzi, B., Sati, H., Ivanovska, V., Kothari, K. U., Balkhy, H. H., Cassini, A., Hamers, R. L., Weezenbeek, K. V., ... Parry, C. (2024). WHO global research priorities for antimicrobial resistance in human health. The Lancet Microbe, 5(11), Article 100902. https://doi.org/10.1016/s2666-5247(24)00134-4

@article{60f0d9d48ae244fd94f6aa62ccaea03e,

title = "WHO global research priorities for antimicrobial resistance in human health",

abstract = "The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.",

author = "Silvia Bertagnolio and Zlatina Dobreva and Centner, \{Chad M.\} and Olaru, \{Ioana Diana\} and Daniele Don{\`a} and Stefano Burzo and Huttner, \{Benedikt D.\} and Antoine Chaillon and Nebiat Gebreselassie and Teodora Wi and Mateusz Hasso-Agopsowicz and Benedetta Allegranzi and Hatim Sati and Verica Ivanovska and Kothari, \{Kavita U.\} and Balkhy, \{Hanan H.\} and Alessandro Cassini and Hamers, \{Raph L.\} and Weezenbeek, \{Kitty Van\} and David Aanensen and Alexandre Alanio and Ana Alastruey-Izquierdo and Tinsae Alemayehu and Majdi Al-Hasan and Karel Allegaert and Al-Maani, \{Amal Saif\} and Jameela Al-Salman and Alshukairi, \{Abeer Nizar\} and Afreenish Amir and Tanya Applegate and Araj, \{George F.\} and Villalobos, \{Marlen Arce\} and Christine {\AA}rdal and Diane Ashiru-Oredope and Ashley, \{Elizabeth A.\} and Babin, \{Fran{\c c}ois Xavier\} and Bachmann, \{Laura H.\} and Till Bachmann and Baker, \{Kate Susan\} and Manica Balasegaram and Colleen Bamford and Fernando Baquero and Barcelona, \{Laura Isabel\} and Quique Bassat and Matteo Bassetti and Sulagna Basu and Justin Beardsley and V{\'a}squez, \{Grey Benoit\} and Nick Feasey and Christopher Parry",

year = "2024",

month = nov,

day = "7",

doi = "10.1016/s2666-5247(24)00134-4",

language = "English",

volume = "5",

journal = "The Lancet Microbe",

issn = "2666-5247",

publisher = "Elsevier Ltd",

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}

Bertagnolio, S, Dobreva, Z, Centner, CM, Olaru, ID, Donà, D, Burzo, S, Huttner, BD, Chaillon, A, Gebreselassie, N, Wi, T, Hasso-Agopsowicz, M, Allegranzi, B, Sati, H, Ivanovska, V, Kothari, KU, Balkhy, HH, Cassini, A, Hamers, RL, Weezenbeek, KV, Aanensen, D, Alanio, A, Alastruey-Izquierdo, A, Alemayehu, T, Al-Hasan, M, Allegaert, K, Al-Maani, AS, Al-Salman, J, Alshukairi, AN, Amir, A, Applegate, T, Araj, GF, Villalobos, MA, Årdal, C, Ashiru-Oredope, D, Ashley, EA, Babin, FX, Bachmann, LH, Bachmann, T, Baker, KS, Balasegaram, M, Bamford, C, Baquero, F, Barcelona, LI, Bassat, Q, Bassetti, M, Basu, S, Beardsley, J, Vásquez, GB, Feasey, N & Parry, C 2024, 'WHO global research priorities for antimicrobial resistance in human health', The Lancet Microbe, vol. 5, no. 11, 100902. https://doi.org/10.1016/s2666-5247(24)00134-4

TY - JOUR

T1 - WHO global research priorities for antimicrobial resistance in human health

AU - Bertagnolio, Silvia

AU - Dobreva, Zlatina

AU - Centner, Chad M.

AU - Olaru, Ioana Diana

AU - Donà, Daniele

AU - Burzo, Stefano

AU - Huttner, Benedikt D.

AU - Chaillon, Antoine

AU - Gebreselassie, Nebiat

AU - Wi, Teodora

AU - Hasso-Agopsowicz, Mateusz

AU - Allegranzi, Benedetta

AU - Sati, Hatim

AU - Ivanovska, Verica

AU - Kothari, Kavita U.

AU - Balkhy, Hanan H.

AU - Cassini, Alessandro

AU - Hamers, Raph L.

AU - Weezenbeek, Kitty Van

AU - Aanensen, David

AU - Alanio, Alexandre

AU - Alastruey-Izquierdo, Ana

AU - Alemayehu, Tinsae

AU - Al-Hasan, Majdi

AU - Allegaert, Karel

AU - Al-Maani, Amal Saif

AU - Al-Salman, Jameela

AU - Alshukairi, Abeer Nizar

AU - Amir, Afreenish

AU - Applegate, Tanya

AU - Araj, George F.

AU - Villalobos, Marlen Arce

AU - Årdal, Christine

AU - Ashiru-Oredope, Diane

AU - Ashley, Elizabeth A.

AU - Babin, François Xavier

AU - Bachmann, Laura H.

AU - Bachmann, Till

AU - Baker, Kate Susan

AU - Balasegaram, Manica

AU - Bamford, Colleen

AU - Baquero, Fernando

AU - Barcelona, Laura Isabel

AU - Bassat, Quique

AU - Bassetti, Matteo

AU - Basu, Sulagna

AU - Beardsley, Justin

AU - Vásquez, Grey Benoit

AU - Feasey, Nick

AU - Parry, Christopher

PY - 2024/11/7

Y1 - 2024/11/7

N2 - The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

AB - The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

U2 - 10.1016/s2666-5247(24)00134-4

DO - 10.1016/s2666-5247(24)00134-4

M3 - Review article

SN - 2666-5247

VL - 5

JO - The Lancet Microbe

JF - The Lancet Microbe

IS - 11

M1 - 100902

ER -

WHO global research priorities for antimicrobial resistance in human health

Abstract

UN SDGs

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