Visceral leishmaniasis: elimination with existing
interventions

Greg Matlashewski; Byron Arana; Axel Kroeger; Sujit Battacharaya; Shyam Sundar; Pradeep Das; Prabhat Kumar Sinha; Suman Rijal; Dinesh Mondal; Dan Zilberstein; Jorge Alvar

doi:10.1016/s1473-3099(10)70320-0

Visceral leishmaniasis: elimination with existing interventions

Greg Matlashewski, Byron Arana, Axel Kroeger, Sujit Battacharaya, Shyam Sundar, Pradeep Das, Prabhat Kumar Sinha, Suman Rijal, Dinesh Mondal, Dan Zilberstein, Jorge Alvar

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

The world’s burden of infectious diseases can be substantially reduced by more-eff ective use of existing interventions.

Advances in case detection, diagnosis, and treatment strategies have made it possible to consider the elimination of

visceral leishmaniasis in the Indian subcontinent. The priority must now be to eff ectively implement existing

interventions at the community level by actively fi nding cases in endemic villages and treating them with single-dose

liposomal amphotericin B at primary-health-care centres. Once the elimination target of one case per 10 000 population

has been reached, combination therapies involving miltefosine and paromomycin can be introduced to ensure longterm

availability of several drugs for visceral leishmaniasis and to protect against resistance.

Original language	English
Pages (from-to)	322-325
Number of pages	4
Journal	The Lancet Infectious Diseases
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/s1473-3099(10)70320-0
Publication status	Published - 1 Apr 2011
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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T1 - Visceral leishmaniasis: elimination with existing interventions

AU - Matlashewski, Greg

AU - Arana, Byron

AU - Kroeger, Axel

AU - Battacharaya, Sujit

AU - Sundar, Shyam

AU - Das, Pradeep

AU - Sinha, Prabhat Kumar

AU - Rijal, Suman

AU - Mondal, Dinesh

AU - Zilberstein, Dan

AU - Alvar, Jorge

PY - 2011/4/1

Y1 - 2011/4/1

N2 - The world’s burden of infectious diseases can be substantially reduced by more-eff ective use of existing interventions.Advances in case detection, diagnosis, and treatment strategies have made it possible to consider the elimination ofvisceral leishmaniasis in the Indian subcontinent. The priority must now be to eff ectively implement existinginterventions at the community level by actively fi nding cases in endemic villages and treating them with single-doseliposomal amphotericin B at primary-health-care centres. Once the elimination target of one case per 10 000 populationhas been reached, combination therapies involving miltefosine and paromomycin can be introduced to ensure longtermavailability of several drugs for visceral leishmaniasis and to protect against resistance.

AB - The world’s burden of infectious diseases can be substantially reduced by more-eff ective use of existing interventions.Advances in case detection, diagnosis, and treatment strategies have made it possible to consider the elimination ofvisceral leishmaniasis in the Indian subcontinent. The priority must now be to eff ectively implement existinginterventions at the community level by actively fi nding cases in endemic villages and treating them with single-doseliposomal amphotericin B at primary-health-care centres. Once the elimination target of one case per 10 000 populationhas been reached, combination therapies involving miltefosine and paromomycin can be introduced to ensure longtermavailability of several drugs for visceral leishmaniasis and to protect against resistance.

U2 - 10.1016/s1473-3099(10)70320-0

DO - 10.1016/s1473-3099(10)70320-0

M3 - Article

SN - 1473-3099

VL - 11

SP - 322

EP - 325

JO - The Lancet Infectious Diseases

JF - The Lancet Infectious Diseases

IS - 4

ER -

Visceral leishmaniasis: elimination with existing interventions

Abstract

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