VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy

Ana Maria Fonseca; Raquel González; Azucena Bardají; Chenjerai Jairoce; Maria Rupérez; Alfons Jiménez; Llorenç Quintó; Pau Cisteró; Anifa Vala; Charfudin Sacoor; Himanshu Gupta; Jennifer Hegewisch-Taylor; Joe Brew; Nicaise Tuikue Ndam; Simon Kariuki; Marta López; Carlota Dobaño; Chetan E. Chitnis; Peter Ouma; Michael Ramharter; Salim Abdulla; John J. Aponte; Achille Massougbodji; Valerie Briand; Ghyslain Mombo-Ngoma; Meghna Desai; Michel Cot; Arsenio Nhacolo; Esperança Sevene; Eusebio Macete; Clara Menéndez; Alfredo Mayor

doi:10.3201/eid2510.181177

VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy

Ana Maria Fonseca, Raquel González, Azucena Bardají, Chenjerai Jairoce, Maria Rupérez, Alfons Jiménez, Llorenç Quintó, Pau Cisteró, Anifa Vala, Charfudin Sacoor, Himanshu Gupta, Jennifer Hegewisch-Taylor, Joe Brew, Nicaise Tuikue Ndam, Simon Kariuki, Marta López, Carlota Dobaño, Chetan E. Chitnis, Peter Ouma, Michael RamharterSalim Abdulla, John J. Aponte, Achille Massougbodji, Valerie Briand, Ghyslain Mombo-Ngoma, Meghna Desai, Michel Cot, Arsenio Nhacolo, Esperança Sevene, Eusebio Macete, Clara Menéndez, Alfredo Mayor

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.

Original language	English
Pages (from-to)	1851-1860
Number of pages	10
Journal	Emerging Infectious Diseases
Volume	25
Issue number	10
DOIs	https://doi.org/10.3201/eid2510.181177
Publication status	Published - 30 Aug 2019

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Fonseca, A. M., González, R., Bardají, A., Jairoce, C., Rupérez, M., Jiménez, A., Quintó, L., Cisteró, P., Vala, A., Sacoor, C., Gupta, H., Hegewisch-Taylor, J., Brew, J., Ndam, N. T., Kariuki, S., López, M., Dobaño, C., Chitnis, C. E., Ouma, P., ... Mayor, A. (2019). VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy. Emerging Infectious Diseases, 25(10), 1851-1860. https://doi.org/10.3201/eid2510.181177

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title = "VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy",

abstract = "Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.",

author = "Fonseca, \{Ana Maria\} and Raquel Gonz{\'a}lez and Azucena Bardaj{\'i} and Chenjerai Jairoce and Maria Rup{\'e}rez and Alfons Jim{\'e}nez and Lloren{\c c} Quint{\'o} and Pau Cister{\'o} and Anifa Vala and Charfudin Sacoor and Himanshu Gupta and Jennifer Hegewisch-Taylor and Joe Brew and Ndam, \{Nicaise Tuikue\} and Simon Kariuki and Marta L{\'o}pez and Carlota Doba{\~n}o and Chitnis, \{Chetan E.\} and Peter Ouma and Michael Ramharter and Salim Abdulla and Aponte, \{John J.\} and Achille Massougbodji and Valerie Briand and Ghyslain Mombo-Ngoma and Meghna Desai and Michel Cot and Arsenio Nhacolo and Esperan{\c c}a Sevene and Eusebio Macete and Clara Men{\'e}ndez and Alfredo Mayor",

year = "2019",

month = aug,

day = "30",

doi = "10.3201/eid2510.181177",

language = "English",

volume = "25",

pages = "1851--1860",

journal = "Emerging Infectious Diseases",

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Fonseca, AM, González, R, Bardají, A, Jairoce, C, Rupérez, M, Jiménez, A, Quintó, L, Cisteró, P, Vala, A, Sacoor, C, Gupta, H, Hegewisch-Taylor, J, Brew, J, Ndam, NT, Kariuki, S, López, M, Dobaño, C, Chitnis, CE, Ouma, P, Ramharter, M, Abdulla, S, Aponte, JJ, Massougbodji, A, Briand, V, Mombo-Ngoma, G, Desai, M, Cot, M, Nhacolo, A, Sevene, E, Macete, E, Menéndez, C & Mayor, A 2019, 'VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy', Emerging Infectious Diseases, vol. 25, no. 10, pp. 1851-1860. https://doi.org/10.3201/eid2510.181177

TY - JOUR

T1 - VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy

AU - Fonseca, Ana Maria

AU - González, Raquel

AU - Bardají, Azucena

AU - Jairoce, Chenjerai

AU - Rupérez, Maria

AU - Jiménez, Alfons

AU - Quintó, Llorenç

AU - Cisteró, Pau

AU - Vala, Anifa

AU - Sacoor, Charfudin

AU - Gupta, Himanshu

AU - Hegewisch-Taylor, Jennifer

AU - Brew, Joe

AU - Ndam, Nicaise Tuikue

AU - Kariuki, Simon

AU - López, Marta

AU - Dobaño, Carlota

AU - Chitnis, Chetan E.

AU - Ouma, Peter

AU - Ramharter, Michael

AU - Abdulla, Salim

AU - Aponte, John J.

AU - Massougbodji, Achille

AU - Briand, Valerie

AU - Mombo-Ngoma, Ghyslain

AU - Desai, Meghna

AU - Cot, Michel

AU - Nhacolo, Arsenio

AU - Sevene, Esperança

AU - Macete, Eusebio

AU - Menéndez, Clara

AU - Mayor, Alfredo

PY - 2019/8/30

Y1 - 2019/8/30

N2 - Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.

AB - Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.

UR - https://www.scopus.com/pages/publications/85072408362

U2 - 10.3201/eid2510.181177

DO - 10.3201/eid2510.181177

M3 - Article

C2 - 31538557

AN - SCOPUS:85072408362

SN - 1080-6040

VL - 25

SP - 1851

EP - 1860

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 10

ER -

VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy

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