Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia

Katherine R.W. Emary; Michael J. Carter; Sreymom Pol; Soeng Sona; Varun Kumar; Nicholas P.J. Day; Christopher Parry; Catrin E. Moore

doi:10.1111/tmi.12398

Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia

Katherine R.W. Emary, Michael J. Carter, Sreymom Pol, Soeng Sona, Varun Kumar, Nicholas P.J. Day, Christopher Parry, Catrin E. Moore

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Objective

Antibiotic resistance is a prominent public and global health concern. We investigated antibiotic use in children by determining the proportion of unselected children with antibacterial activity in their urine attending a paediatric outpatient department in Siem Reap, Cambodia.

Methods

Caregiver reports of medication history and presence of possible infection symptoms were collected in addition to urine samples. Urine antibiotic activity was estimated by exposing bacteria to urine specimens, including assessment against multiresistant bacteria previously isolated from patients in the hospital (a methicillin-resistant Staphylococcus aureus (MRSA), a multiresistant Salmonella typhi and an extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate).

Results

Medication information and urine were collected from 775 children. Caregivers reported medication use in 69.0% of children in the preceding 48 h. 31.7% samples showed antibacterial activity; 16.3% showed activity against a local multiresistant organism. No specimens demonstrated activity against an ESBL-producing E. coli.

Conclusions

Antibiotics are widely used in the community setting in Cambodia. Parents are often ill-informed about drugs given to treat their children. Increasing the regulation and training of private pharmacies in Cambodia may be necessary. Regional surveillance of antibiotic use and resistance is also essential in devising preventive strategies against further development of antibiotic resistance, which would have both local and global consequences.

Original language	English
Pages (from-to)	24-28
Number of pages	5
Journal	Tropical Medicine and International Health
Volume	20
Issue number	1
DOIs	https://doi.org/10.1111/tmi.12398
Publication status	Published - 1 Jan 2015

Keywords

Antibiotics
Cambodia
Paediatric

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10.1111/tmi.12398Licence: CC BY

Trop Med Int Health 20 1 24-28Final published version, 60.4 KBLicence: CC BY

Cite this

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title = "Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia",

abstract = "ObjectiveAntibiotic resistance is a prominent public and global health concern. We investigated antibiotic use in children by determining the proportion of unselected children with antibacterial activity in their urine attending a paediatric outpatient department in Siem Reap, Cambodia.MethodsCaregiver reports of medication history and presence of possible infection symptoms were collected in addition to urine samples. Urine antibiotic activity was estimated by exposing bacteria to urine specimens, including assessment against multiresistant bacteria previously isolated from patients in the hospital (a methicillin-resistant Staphylococcus aureus (MRSA), a multiresistant Salmonella typhi and an extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate).ResultsMedication information and urine were collected from 775 children. Caregivers reported medication use in 69.0\% of children in the preceding 48 h. 31.7\% samples showed antibacterial activity; 16.3\% showed activity against a local multiresistant organism. No specimens demonstrated activity against an ESBL-producing E. coli.ConclusionsAntibiotics are widely used in the community setting in Cambodia. Parents are often ill-informed about drugs given to treat their children. Increasing the regulation and training of private pharmacies in Cambodia may be necessary. Regional surveillance of antibiotic use and resistance is also essential in devising preventive strategies against further development of antibiotic resistance, which would have both local and global consequences.",

keywords = "Antibiotics, Cambodia, Paediatric",

author = "Emary, \{Katherine R.W.\} and Carter, \{Michael J.\} and Sreymom Pol and Soeng Sona and Varun Kumar and Day, \{Nicholas P.J.\} and Christopher Parry and Moore, \{Catrin E.\}",

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T1 - Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia

AU - Emary, Katherine R.W.

AU - Carter, Michael J.

AU - Pol, Sreymom

AU - Sona, Soeng

AU - Kumar, Varun

AU - Day, Nicholas P.J.

AU - Parry, Christopher

AU - Moore, Catrin E.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - ObjectiveAntibiotic resistance is a prominent public and global health concern. We investigated antibiotic use in children by determining the proportion of unselected children with antibacterial activity in their urine attending a paediatric outpatient department in Siem Reap, Cambodia.MethodsCaregiver reports of medication history and presence of possible infection symptoms were collected in addition to urine samples. Urine antibiotic activity was estimated by exposing bacteria to urine specimens, including assessment against multiresistant bacteria previously isolated from patients in the hospital (a methicillin-resistant Staphylococcus aureus (MRSA), a multiresistant Salmonella typhi and an extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate).ResultsMedication information and urine were collected from 775 children. Caregivers reported medication use in 69.0% of children in the preceding 48 h. 31.7% samples showed antibacterial activity; 16.3% showed activity against a local multiresistant organism. No specimens demonstrated activity against an ESBL-producing E. coli.ConclusionsAntibiotics are widely used in the community setting in Cambodia. Parents are often ill-informed about drugs given to treat their children. Increasing the regulation and training of private pharmacies in Cambodia may be necessary. Regional surveillance of antibiotic use and resistance is also essential in devising preventive strategies against further development of antibiotic resistance, which would have both local and global consequences.

AB - ObjectiveAntibiotic resistance is a prominent public and global health concern. We investigated antibiotic use in children by determining the proportion of unselected children with antibacterial activity in their urine attending a paediatric outpatient department in Siem Reap, Cambodia.MethodsCaregiver reports of medication history and presence of possible infection symptoms were collected in addition to urine samples. Urine antibiotic activity was estimated by exposing bacteria to urine specimens, including assessment against multiresistant bacteria previously isolated from patients in the hospital (a methicillin-resistant Staphylococcus aureus (MRSA), a multiresistant Salmonella typhi and an extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolate).ResultsMedication information and urine were collected from 775 children. Caregivers reported medication use in 69.0% of children in the preceding 48 h. 31.7% samples showed antibacterial activity; 16.3% showed activity against a local multiresistant organism. No specimens demonstrated activity against an ESBL-producing E. coli.ConclusionsAntibiotics are widely used in the community setting in Cambodia. Parents are often ill-informed about drugs given to treat their children. Increasing the regulation and training of private pharmacies in Cambodia may be necessary. Regional surveillance of antibiotic use and resistance is also essential in devising preventive strategies against further development of antibiotic resistance, which would have both local and global consequences.

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KW - Cambodia

KW - Paediatric

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SN - 1360-2276

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JO - Tropical Medicine and International Health

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Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia

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