Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19

Benedikt Strunz; Christopher Maucourant; Adi Mehta; Hui Wan; Likun Du; Dan Sun; Puran Chen; Anna Nordlander; Yu Gao; Martin Cornillet; Jonna Bister; Egle Kvedaraite; Wanda Christ; Jonas Klingström; Daniel Geanon; Åsa Parke; Anna Ekwall-Larson; Laura Rivino; Paul A. MacAry; Soo Aleman; Marcus Buggert; Hans Gustaf Ljunggren; Qiang Pan-Hammarström; Fridtjof Lund-Johansen; Kristoffer Strålin; Niklas K. Björkström

doi:10.1093/infdis/jiae036

Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19

Benedikt Strunz
, Christopher Maucourant
, Adi Mehta
, Hui Wan
, Likun Du
, Dan Sun
, Puran Chen
, Anna Nordlander
, Yu Gao
, Martin Cornillet
, Jonna Bister
, Egle Kvedaraite
, Wanda Christ
, Jonas Klingström
, Daniel Geanon
, Åsa Parke
, Anna Ekwall-Larson
, Laura Rivino
, Paul A. MacAry
, Soo Aleman

Marcus Buggert, Hans Gustaf Ljunggren, Qiang Pan-Hammarström, Fridtjof Lund-Johansen, Kristoffer Strålin, Niklas K. Björkström

Karolinska Institutet
University of Oslo
University of Bristol
DUKE-NUS Medical School, Singapore
National University of Singapore

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background.

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19).

Methods.

This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity.

Results.

aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways.

Conclusions.

Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.

Original language	English
Pages (from-to)	e318-e326
Journal	Journal of Infectious Diseases
Volume	230
Issue number	2
Early online date	29 Feb 2024
DOIs	https://doi.org/10.1093/infdis/jiae036
Publication status	Published - 15 Aug 2024
Externally published	Yes

Keywords

autoantibodies
COVID-19
immunity
interferon

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10.1093/infdis/jiae036Licence: CC BY

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Strunz, B., Maucourant, C., Mehta, A., Wan, H., Du, L., Sun, D., Chen, P., Nordlander, A., Gao, Y., Cornillet, M., Bister, J., Kvedaraite, E., Christ, W., Klingström, J., Geanon, D., Parke, Å., Ekwall-Larson, A., Rivino, L., MacAry, P. A., ... Björkström, N. K. (2024). Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19. Journal of Infectious Diseases, 230(2), e318-e326. https://doi.org/10.1093/infdis/jiae036

@article{b54a9c29d7e04bfb8adecb1f439b6686,

title = "Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19",

abstract = "Background. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19). Methods. This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity. Results. aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways. Conclusions. Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.",

keywords = "autoantibodies, COVID-19, immunity, interferon",

author = "Benedikt Strunz and Christopher Maucourant and Adi Mehta and Hui Wan and Likun Du and Dan Sun and Puran Chen and Anna Nordlander and Yu Gao and Martin Cornillet and Jonna Bister and Egle Kvedaraite and Wanda Christ and Jonas Klingstr{\"o}m and Daniel Geanon and {\AA}sa Parke and Anna Ekwall-Larson and Laura Rivino and MacAry, \{Paul A.\} and Soo Aleman and Marcus Buggert and Ljunggren, \{Hans Gustaf\} and Qiang Pan-Hammarstr{\"o}m and Fridtjof Lund-Johansen and Kristoffer Str{\aa}lin and Bj{\"o}rkstr{\"o}m, \{Niklas K.\}",

year = "2024",

month = aug,

day = "15",

doi = "10.1093/infdis/jiae036",

language = "English",

volume = "230",

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journal = "Journal of Infectious Diseases",

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Strunz, B, Maucourant, C, Mehta, A, Wan, H, Du, L, Sun, D, Chen, P, Nordlander, A, Gao, Y, Cornillet, M, Bister, J, Kvedaraite, E, Christ, W, Klingström, J, Geanon, D, Parke, Å, Ekwall-Larson, A, Rivino, L, MacAry, PA, Aleman, S, Buggert, M, Ljunggren, HG, Pan-Hammarström, Q, Lund-Johansen, F, Strålin, K & Björkström, NK 2024, 'Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19', Journal of Infectious Diseases, vol. 230, no. 2, pp. e318-e326. https://doi.org/10.1093/infdis/jiae036

TY - JOUR

T1 - Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19

AU - Strunz, Benedikt

AU - Maucourant, Christopher

AU - Mehta, Adi

AU - Wan, Hui

AU - Du, Likun

AU - Sun, Dan

AU - Chen, Puran

AU - Nordlander, Anna

AU - Gao, Yu

AU - Cornillet, Martin

AU - Bister, Jonna

AU - Kvedaraite, Egle

AU - Christ, Wanda

AU - Klingström, Jonas

AU - Geanon, Daniel

AU - Parke, Åsa

AU - Ekwall-Larson, Anna

AU - Rivino, Laura

AU - MacAry, Paul A.

AU - Aleman, Soo

AU - Buggert, Marcus

AU - Ljunggren, Hans Gustaf

AU - Pan-Hammarström, Qiang

AU - Lund-Johansen, Fridtjof

AU - Strålin, Kristoffer

AU - Björkström, Niklas K.

PY - 2024/8/15

Y1 - 2024/8/15

N2 - Background. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19). Methods. This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity. Results. aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways. Conclusions. Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.

AB - Background. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to severe disease with increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes to severe coronavirus disease 2019 (COVID-19). Methods. This study aimed to investigate the presence of aIFN-Abs in relation to the soluble proteome, circulating immune cell numbers, and cellular phenotypes, as well as development of adaptive immunity. Results. aIFN-Abs were more prevalent in critical compared to severe COVID-19 but largely absent in the other viral and bacterial infections studied here. The antibody and T-cell response to SARS-CoV-2 remained largely unaffected by the presence aIFN-Abs. Similarly, the inflammatory response in COVID-19 was comparable in individuals with and without aIFN-Abs. Instead, presence of aIFN-Abs had an impact on cellular immune system composition and skewing of cellular immune pathways. Conclusions. Our data suggest that aIFN-Abs do not significantly influence development of adaptive immunity but covary with alterations in immune cell numbers.

KW - autoantibodies

KW - COVID-19

KW - immunity

KW - interferon

U2 - 10.1093/infdis/jiae036

DO - 10.1093/infdis/jiae036

M3 - Article

C2 - 38421006

AN - SCOPUS:85201694131

SN - 0022-1899

VL - 230

SP - e318-e326

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 2

ER -

Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19

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Keywords

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