Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

Paul Elliott; Oliver Eales; Nicholas Steyn; David Tang; Barbara Bodinier; Haowei Wang; Joshua Elliott; Matthew Whitaker; Christina Atchison; Peter Diggle; Andrew J. Page; Alexander J. Trotter; Deborah Ashby; Wendy Barclay; Graham Taylor; Helen Ward; Ara Darzi; Graham S. Cooke; Christl A. Donnelly; Marc Chadeau-Hyam

doi:10.1126/science.abq4411

Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

Paul Elliott, Oliver Eales, Nicholas Steyn, David Tang, Barbara Bodinier, Haowei Wang, Joshua Elliott, Matthew Whitaker, Christina Atchison, Peter Diggle, Andrew J. Page, Alexander J. Trotter, Deborah Ashby, Wendy Barclay, Graham Taylor, Helen Ward, Ara Darzi, Graham S. Cooke, Christl A. Donnelly, Marc Chadeau-Hyam

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Abstract

Rapid transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to record-breaking incidence rates around the world. The Real-time Assessment of Community Transmission-1 (REACT-1) study has tracked SARS-CoV-2 infection in England using reverse transcription polymerase chain reaction (RT-PCR) results from self-administered throat and nose swabs from randomly selected participants aged 5 years and older approximately monthly from May 2020 to March 2022. Weighted prevalence in March 2022 was the highest recorded in REACT-1 at 6.37% (N = 109,181), with the Omicron BA.2 variant largely replacing the BA.1 variant. Prevalence was increasing overall, with the greatest increase in those aged 65 to 74 years and 75 years and older. This was associated with increased hospitalizations and deaths, but at much lower levels than in previous waves against a backdrop of high levels of vaccination.

Original language	English
Article number	1432
Journal	Science
Volume	376
Issue number	6600
DOIs	https://doi.org/10.1126/science.abq4411
Publication status	Published - 24 Jun 2022
Externally published	Yes

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Elliott, P., Eales, O., Steyn, N., Tang, D., Bodinier, B., Wang, H., Elliott, J., Whitaker, M., Atchison, C., Diggle, P., Page, A. J., Trotter, A. J., Ashby, D., Barclay, W., Taylor, G., Ward, H., Darzi, A., Cooke, G. S., Donnelly, C. A., & Chadeau-Hyam, M. (2022). Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England. Science, 376(6600), Article 1432. https://doi.org/10.1126/science.abq4411

@article{d0cf1d75fd874dfa8a1da55c1267e559,

title = "Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England",

abstract = "Rapid transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to record-breaking incidence rates around the world. The Real-time Assessment of Community Transmission-1 (REACT-1) study has tracked SARS-CoV-2 infection in England using reverse transcription polymerase chain reaction (RT-PCR) results from self-administered throat and nose swabs from randomly selected participants aged 5 years and older approximately monthly from May 2020 to March 2022. Weighted prevalence in March 2022 was the highest recorded in REACT-1 at 6.37\% (N = 109,181), with the Omicron BA.2 variant largely replacing the BA.1 variant. Prevalence was increasing overall, with the greatest increase in those aged 65 to 74 years and 75 years and older. This was associated with increased hospitalizations and deaths, but at much lower levels than in previous waves against a backdrop of high levels of vaccination.",

author = "Paul Elliott and Oliver Eales and Nicholas Steyn and David Tang and Barbara Bodinier and Haowei Wang and Joshua Elliott and Matthew Whitaker and Christina Atchison and Peter Diggle and Page, \{Andrew J.\} and Trotter, \{Alexander J.\} and Deborah Ashby and Wendy Barclay and Graham Taylor and Helen Ward and Ara Darzi and Cooke, \{Graham S.\} and Donnelly, \{Christl A.\} and Marc Chadeau-Hyam",

year = "2022",

month = jun,

day = "24",

doi = "10.1126/science.abq4411",

language = "English",

volume = "376",

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publisher = "American Association for the Advancement of Science",

number = "6600",

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Elliott, P, Eales, O, Steyn, N, Tang, D, Bodinier, B, Wang, H, Elliott, J, Whitaker, M, Atchison, C, Diggle, P, Page, AJ, Trotter, AJ, Ashby, D, Barclay, W, Taylor, G, Ward, H, Darzi, A, Cooke, GS, Donnelly, CA & Chadeau-Hyam, M 2022, 'Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England', Science, vol. 376, no. 6600, 1432. https://doi.org/10.1126/science.abq4411

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T1 - Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

AU - Elliott, Paul

AU - Eales, Oliver

AU - Steyn, Nicholas

AU - Tang, David

AU - Bodinier, Barbara

AU - Wang, Haowei

AU - Elliott, Joshua

AU - Whitaker, Matthew

AU - Atchison, Christina

AU - Diggle, Peter

AU - Page, Andrew J.

AU - Trotter, Alexander J.

AU - Ashby, Deborah

AU - Barclay, Wendy

AU - Taylor, Graham

AU - Ward, Helen

AU - Darzi, Ara

AU - Cooke, Graham S.

AU - Donnelly, Christl A.

AU - Chadeau-Hyam, Marc

PY - 2022/6/24

Y1 - 2022/6/24

N2 - Rapid transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to record-breaking incidence rates around the world. The Real-time Assessment of Community Transmission-1 (REACT-1) study has tracked SARS-CoV-2 infection in England using reverse transcription polymerase chain reaction (RT-PCR) results from self-administered throat and nose swabs from randomly selected participants aged 5 years and older approximately monthly from May 2020 to March 2022. Weighted prevalence in March 2022 was the highest recorded in REACT-1 at 6.37% (N = 109,181), with the Omicron BA.2 variant largely replacing the BA.1 variant. Prevalence was increasing overall, with the greatest increase in those aged 65 to 74 years and 75 years and older. This was associated with increased hospitalizations and deaths, but at much lower levels than in previous waves against a backdrop of high levels of vaccination.

AB - Rapid transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to record-breaking incidence rates around the world. The Real-time Assessment of Community Transmission-1 (REACT-1) study has tracked SARS-CoV-2 infection in England using reverse transcription polymerase chain reaction (RT-PCR) results from self-administered throat and nose swabs from randomly selected participants aged 5 years and older approximately monthly from May 2020 to March 2022. Weighted prevalence in March 2022 was the highest recorded in REACT-1 at 6.37% (N = 109,181), with the Omicron BA.2 variant largely replacing the BA.1 variant. Prevalence was increasing overall, with the greatest increase in those aged 65 to 74 years and 75 years and older. This was associated with increased hospitalizations and deaths, but at much lower levels than in previous waves against a backdrop of high levels of vaccination.

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DO - 10.1126/science.abq4411

M3 - Article

SN - 0036-8075

VL - 376

JO - Science

JF - Science

IS - 6600

M1 - 1432

ER -

Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

Abstract

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