Tumor Necrosis Factor and Lymphotoxin-alpha Polymorphisms and Severe Malaria in African Populations

T. G. Clark; M. Diakite; S. Auburn; S. Campino; A. E. Fry; A. Green; A. Richardson; K. Small; Y. Y. Teo; J. Wilson; M. Jallow; F. Sisay-Joof; M. Pinder; M. J. Griffiths; N. Peshu; T. N. Williams; Kevin Marsh; Malcolm E Molyneux; T. E. Taylor; K. A. Rockett; D. P. Kwiatkowski

doi:10.1086/596320

Tumor Necrosis Factor and Lymphotoxin-alpha Polymorphisms and Severe Malaria in African Populations

T. G. Clark
, M. Diakite
, S. Auburn
, S. Campino
, A. E. Fry
, A. Green
, A. Richardson
, K. Small
, Y. Y. Teo
, J. Wilson
, M. Jallow
, F. Sisay-Joof
, M. Pinder
, M. J. Griffiths
, N. Peshu
, T. N. Williams
, Kevin Marsh
, Malcolm E Molyneux
, T. E. Taylor
, K. A. Rockett

D. P. Kwiatkowski

Liverpool School of Tropical Medicine

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving > 10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the TNF - 238 polymorphism and SM in The Gambia. However, no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi. It has been suggested that the causal polymorphisms regulating the TNF and LTA responses may be located some distance from the genes. Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms.

Original language	English
Pages (from-to)	569-575
Number of pages	7
Journal	Journal of Infectious Diseases
Volume	199
Issue number	4
DOIs	https://doi.org/10.1086/596320
Publication status	Published - 1 Feb 2009

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SDG 3 Good Health and Well-being

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Clark, T. G., Diakite, M., Auburn, S., Campino, S., Fry, A. E., Green, A., Richardson, A., Small, K., Teo, Y. Y., Wilson, J., Jallow, M., Sisay-Joof, F., Pinder, M., Griffiths, M. J., Peshu, N., Williams, T. N., Marsh, K., Molyneux, M. E., Taylor, T. E., ... Kwiatkowski, D. P. (2009). Tumor Necrosis Factor and Lymphotoxin-alpha Polymorphisms and Severe Malaria in African Populations. Journal of Infectious Diseases, 199(4), 569-575. https://doi.org/10.1086/596320

@article{1454be0be3c14a3294769d1d03ba29a5,

title = "Tumor Necrosis Factor and Lymphotoxin-alpha Polymorphisms and Severe Malaria in African Populations",

abstract = "The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving > 10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the TNF - 238 polymorphism and SM in The Gambia. However, no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi. It has been suggested that the causal polymorphisms regulating the TNF and LTA responses may be located some distance from the genes. Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms.",

author = "Clark, \{T. G.\} and M. Diakite and S. Auburn and S. Campino and Fry, \{A. E.\} and A. Green and A. Richardson and K. Small and Teo, \{Y. Y.\} and J. Wilson and M. Jallow and F. Sisay-Joof and M. Pinder and Griffiths, \{M. J.\} and N. Peshu and Williams, \{T. N.\} and Kevin Marsh and Molyneux, \{Malcolm E\} and Taylor, \{T. E.\} and Rockett, \{K. A.\} and Kwiatkowski, \{D. P.\}",

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doi = "10.1086/596320",

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Clark, TG, Diakite, M, Auburn, S, Campino, S, Fry, AE, Green, A, Richardson, A, Small, K, Teo, YY, Wilson, J, Jallow, M, Sisay-Joof, F, Pinder, M, Griffiths, MJ, Peshu, N, Williams, TN, Marsh, K, Molyneux, ME, Taylor, TE, Rockett, KA & Kwiatkowski, DP 2009, 'Tumor Necrosis Factor and Lymphotoxin-alpha Polymorphisms and Severe Malaria in African Populations', Journal of Infectious Diseases, vol. 199, no. 4, pp. 569-575. https://doi.org/10.1086/596320

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T1 - Tumor Necrosis Factor and Lymphotoxin-alpha Polymorphisms and Severe Malaria in African Populations

AU - Clark, T. G.

AU - Diakite, M.

AU - Auburn, S.

AU - Campino, S.

AU - Fry, A. E.

AU - Green, A.

AU - Richardson, A.

AU - Small, K.

AU - Teo, Y. Y.

AU - Wilson, J.

AU - Jallow, M.

AU - Sisay-Joof, F.

AU - Pinder, M.

AU - Griffiths, M. J.

AU - Peshu, N.

AU - Williams, T. N.

AU - Marsh, Kevin

AU - Molyneux, Malcolm E

AU - Taylor, T. E.

AU - Rockett, K. A.

AU - Kwiatkowski, D. P.

PY - 2009/2/1

Y1 - 2009/2/1

N2 - The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving > 10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the TNF - 238 polymorphism and SM in The Gambia. However, no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi. It has been suggested that the causal polymorphisms regulating the TNF and LTA responses may be located some distance from the genes. Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms.

AB - The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving > 10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the TNF - 238 polymorphism and SM in The Gambia. However, no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi. It has been suggested that the causal polymorphisms regulating the TNF and LTA responses may be located some distance from the genes. Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms.

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DO - 10.1086/596320

M3 - Article

SN - 0022-1899

VL - 199

SP - 569

EP - 575

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 4

ER -

Tumor Necrosis Factor and Lymphotoxin-alpha Polymorphisms and Severe Malaria in African Populations

Abstract

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