Trypanocidal effects of catecholamines and indolealkylamines

A. Owolabi; C. Wilson; David Molyneux; V. W. Pentreath

doi:10.1080/00034983.1990.11812445

Trypanocidal effects of catecholamines and indolealkylamines

A. Owolabi, C. Wilson, David Molyneux, V. W. Pentreath

University of Salford

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Catecholamines, indolealkylamines, and their anologues are oxidized at neutral or alkaline pH, producing hydrogen peroxide, quinones and free radicals. Several of these amines were tested for trypanocidal effects on Trypanosoma brucei, which posses a well-documented vulnerability to such oxidation products. Dopamine, 5-hydroxydopamine (5-OHDA), 6-hydroxydopamine (6-OHDA), 5-hydroxytryptamine (5-HT), 5,6-dihydroxytryptamine (5,6-DHT) and 5,7-dihydroxytryptamine (5,7-DHT) killed te parasites in vitro, using a fibroblast feeder layer cell culture system, in four to 48 hours at concentrations of 10-5-10-7M. The 5-OHDA, 6-OHDA, 5,6-DHT and 5,7-DHT were also effective in vivo when tested by intraperitoneal injection of infected mice.

Original language	English
Pages (from-to)	127-131
Number of pages	5
Journal	Pathogens and Global Health
Volume	84
Issue number	2
DOIs	https://doi.org/10.1080/00034983.1990.11812445
Publication status	Published - 1 Jan 1990
Externally published	Yes

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10.1080/00034983.1990.11812445

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title = "Trypanocidal effects of catecholamines and indolealkylamines",

abstract = "Catecholamines, indolealkylamines, and their anologues are oxidized at neutral or alkaline pH, producing hydrogen peroxide, quinones and free radicals. Several of these amines were tested for trypanocidal effects on Trypanosoma brucei, which posses a well-documented vulnerability to such oxidation products. Dopamine, 5-hydroxydopamine (5-OHDA), 6-hydroxydopamine (6-OHDA), 5-hydroxytryptamine (5-HT), 5,6-dihydroxytryptamine (5,6-DHT) and 5,7-dihydroxytryptamine (5,7-DHT) killed te parasites in vitro, using a fibroblast feeder layer cell culture system, in four to 48 hours at concentrations of 10-5-10-7M. The 5-OHDA, 6-OHDA, 5,6-DHT and 5,7-DHT were also effective in vivo when tested by intraperitoneal injection of infected mice.",

author = "A. Owolabi and C. Wilson and David Molyneux and Pentreath, \{V. W.\}",

year = "1990",

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doi = "10.1080/00034983.1990.11812445",

language = "English",

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T1 - Trypanocidal effects of catecholamines and indolealkylamines

AU - Owolabi, A.

AU - Wilson, C.

AU - Molyneux, David

AU - Pentreath, V. W.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Catecholamines, indolealkylamines, and their anologues are oxidized at neutral or alkaline pH, producing hydrogen peroxide, quinones and free radicals. Several of these amines were tested for trypanocidal effects on Trypanosoma brucei, which posses a well-documented vulnerability to such oxidation products. Dopamine, 5-hydroxydopamine (5-OHDA), 6-hydroxydopamine (6-OHDA), 5-hydroxytryptamine (5-HT), 5,6-dihydroxytryptamine (5,6-DHT) and 5,7-dihydroxytryptamine (5,7-DHT) killed te parasites in vitro, using a fibroblast feeder layer cell culture system, in four to 48 hours at concentrations of 10-5-10-7M. The 5-OHDA, 6-OHDA, 5,6-DHT and 5,7-DHT were also effective in vivo when tested by intraperitoneal injection of infected mice.

AB - Catecholamines, indolealkylamines, and their anologues are oxidized at neutral or alkaline pH, producing hydrogen peroxide, quinones and free radicals. Several of these amines were tested for trypanocidal effects on Trypanosoma brucei, which posses a well-documented vulnerability to such oxidation products. Dopamine, 5-hydroxydopamine (5-OHDA), 6-hydroxydopamine (6-OHDA), 5-hydroxytryptamine (5-HT), 5,6-dihydroxytryptamine (5,6-DHT) and 5,7-dihydroxytryptamine (5,7-DHT) killed te parasites in vitro, using a fibroblast feeder layer cell culture system, in four to 48 hours at concentrations of 10-5-10-7M. The 5-OHDA, 6-OHDA, 5,6-DHT and 5,7-DHT were also effective in vivo when tested by intraperitoneal injection of infected mice.

U2 - 10.1080/00034983.1990.11812445

DO - 10.1080/00034983.1990.11812445

M3 - Article

SN - 2047-7724

VL - 84

SP - 127

EP - 131

JO - Pathogens and Global Health

JF - Pathogens and Global Health

IS - 2

ER -

Trypanocidal effects of catecholamines and indolealkylamines

Abstract

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