Trichomonas vaginalis pathobiology new insights from the genome sequence.

Robert P. Hirt; Natalia de Miguel; Sirintra Nakjang; Daniele Dessi; Yuk Chien Liu; Nicia Diaz; Paola Rappelli; Alvaro Acosta-Serrano; Pier Luigi Fiori; Jeremy C. Mottram

doi:10.1016/b978-0-12-391429-3.00006-x

Trichomonas vaginalis pathobiology new insights from the genome sequence.

Robert P. Hirt, Natalia de Miguel, Sirintra Nakjang, Daniele Dessi, Yuk Chien Liu, Nicia Diaz, Paola Rappelli, Alvaro Acosta-Serrano, Pier Luigi Fiori, Jeremy C. Mottram

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

The draft genome of the common sexually transmitted pathogen Trichomonas vaginalis encodes one of the largest known proteome with 60,000 candidate proteins. This provides parasitologists and molecular cell biologists alike with exciting, yet challenging, opportunities to unravel the molecular features of the parasite's cellular systems and potentially the molecular basis of its pathobiology. Here, recent investigations addressing selected aspects of the parasite's molecular cell biology are discussed, including surface and secreted virulent factors, membrane trafficking, cell signalling, the degradome, and the potential role of RNA interference in the regulation of gene expression.

Original language	English
Pages (from-to)	87-140
Number of pages	54
Journal	Advances in Parasitology
DOIs	https://doi.org/10.1016/b978-0-12-391429-3.00006-x
Publication status	Published - 1 Dec 2011

Keywords

Autophagy-phagocytosis
Endocytosis-multi-vesicular bodies
Glycocalyx
Peptidases-proteases
Pore-forming proteins
Protein kinases
Proteomics
RNAi gene silencing
Signal transduction
Surface proteins

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10.1016/b978-0-12-391429-3.00006-x

Cite this

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title = "Trichomonas vaginalis pathobiology new insights from the genome sequence.",

abstract = "The draft genome of the common sexually transmitted pathogen Trichomonas vaginalis encodes one of the largest known proteome with 60,000 candidate proteins. This provides parasitologists and molecular cell biologists alike with exciting, yet challenging, opportunities to unravel the molecular features of the parasite's cellular systems and potentially the molecular basis of its pathobiology. Here, recent investigations addressing selected aspects of the parasite's molecular cell biology are discussed, including surface and secreted virulent factors, membrane trafficking, cell signalling, the degradome, and the potential role of RNA interference in the regulation of gene expression.",

keywords = "Autophagy-phagocytosis, Endocytosis-multi-vesicular bodies, Glycocalyx, Peptidases-proteases, Pore-forming proteins, Protein kinases, Proteomics, RNAi gene silencing, Signal transduction, Surface proteins",

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doi = "10.1016/b978-0-12-391429-3.00006-x",

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AU - Hirt, Robert P.

AU - de Miguel, Natalia

AU - Nakjang, Sirintra

AU - Dessi, Daniele

AU - Liu, Yuk Chien

AU - Diaz, Nicia

AU - Rappelli, Paola

AU - Acosta-Serrano, Alvaro

AU - Fiori, Pier Luigi

AU - Mottram, Jeremy C.

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N2 - The draft genome of the common sexually transmitted pathogen Trichomonas vaginalis encodes one of the largest known proteome with 60,000 candidate proteins. This provides parasitologists and molecular cell biologists alike with exciting, yet challenging, opportunities to unravel the molecular features of the parasite's cellular systems and potentially the molecular basis of its pathobiology. Here, recent investigations addressing selected aspects of the parasite's molecular cell biology are discussed, including surface and secreted virulent factors, membrane trafficking, cell signalling, the degradome, and the potential role of RNA interference in the regulation of gene expression.

AB - The draft genome of the common sexually transmitted pathogen Trichomonas vaginalis encodes one of the largest known proteome with 60,000 candidate proteins. This provides parasitologists and molecular cell biologists alike with exciting, yet challenging, opportunities to unravel the molecular features of the parasite's cellular systems and potentially the molecular basis of its pathobiology. Here, recent investigations addressing selected aspects of the parasite's molecular cell biology are discussed, including surface and secreted virulent factors, membrane trafficking, cell signalling, the degradome, and the potential role of RNA interference in the regulation of gene expression.

KW - Autophagy-phagocytosis

KW - Endocytosis-multi-vesicular bodies

KW - Glycocalyx

KW - Peptidases-proteases

KW - Pore-forming proteins

KW - Protein kinases

KW - Proteomics

KW - RNAi gene silencing

KW - Signal transduction

KW - Surface proteins

U2 - 10.1016/b978-0-12-391429-3.00006-x

DO - 10.1016/b978-0-12-391429-3.00006-x

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SP - 87

EP - 140

JO - Advances in Parasitology

JF - Advances in Parasitology

ER -

Trichomonas vaginalis pathobiology new insights from the genome sequence.

Abstract

Keywords

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