Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration: A Multicohort Collaboration

For the D:A:D Study Group; RESPOND cohort study; Erich Tusch; Lene Ryom; Annegret Pelchen-Matthews; Amanda Mocroft; Daniel Elbirt; Cristiana Oprea; Huldrych F. Günthard; Cornelia Staehelin; Robert Zangerle; Isabelle Suarez; Jörg Janne Vehreschild; Ferdinand Wit; Marianna Menozzi; Antonella D.arminio Monforte; Vincenzo Spagnuolo; Christian Pradier; Christina Carlander; Paula Suanzes; Jan Christian Wasmuth; Andrew Carr; Kathy Petoumenos; Frauke Borgans; Fabrice Bonnet; Stephane De Wit; Wafaa El-Sadr; Bastian Neesgaard; Nadine Jaschinski; Lauren Greenberg; Sean R. Hosein; Joel Gallant; Vani Vannappagari; Lital Young; Caroline Sabin; Jens Lundgren; Lars Peters; Joanne Reekie

doi:10.1093/cid/ciae228

Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration: A Multicohort Collaboration

For the D:A:D Study Group
, RESPOND cohort study
, Erich Tusch
, Lene Ryom
, Annegret Pelchen-Matthews
, Amanda Mocroft
, Daniel Elbirt
, Cristiana Oprea
, Huldrych F. Günthard
, Cornelia Staehelin
, Robert Zangerle
, Isabelle Suarez
, Jörg Janne Vehreschild
, Ferdinand Wit
, Marianna Menozzi
, Antonella D.arminio Monforte
, Vincenzo Spagnuolo
, Christian Pradier
, Christina Carlander
, Paula Suanzes

Jan Christian Wasmuth, Andrew Carr, Kathy Petoumenos, Frauke Borgans, Fabrice Bonnet, Stephane De Wit, Wafaa El-Sadr, Bastian Neesgaard, Nadine Jaschinski, Lauren Greenberg, Sean R. Hosein, Joel Gallant, Vani Vannappagari, Lital Young, Caroline Sabin, Jens Lundgren, Lars Peters, Joanne Reekie

Clinical Sciences

University of Copenhagen
University College London
Kaplan Medical Center Israel
Victor Babes National Institute
University of Zurich
University of Bern
Innsbruck Medical University
University of Cologne
Stichting HIV Monitoring
University of Modena and Reggio Emilia
ASST Santi Paolo e Carlo
San Raffaele Scientific Institute
Université Côte d'Azur
Karolinska Institutet
Hospital Vall d'Hebron
University of Bonn
St. Vincent's Hospital Sydney
University of New South Wales
Goethe University Frankfurt
Institut national de la santé et de la recherche médicale
Saint-Pierre University Hospital
Columbia University
European AIDS Treatment Group
Gilead Sciences, Inc.
GlaxoSmithKline
Merck

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background: Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020. Methods: Data were collected from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) cohort between January 1999 through January 2015 and the International Cohort Consortium of Infectious Disease (RESPOND) from October 2017 through December 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV, were calculated. Poisson models were used to assess mortality over time. Results: Among 55 716 participants followed for median 6 years (interquartile range, 3-11), 5263 died (mortality rate [MR], 13.7/1000 person-years of follow-up [PYFU]; 95% confidence interval [CI], 13.4-14.1). Changing mortality was observed: AIDS mortality was most common between 1999-2009 (n = 952; MR, 4.2/1000 PYFU; 95% CI, 4.0-4.5) and non-AIDS-defining malignancy (NADM) between 2010-2020 (n = 444; MR, 2.8/1000 PYFU; 95% CI, 2.5-3.1). In multivariable analysis, all-cause mortality declined (adjusted mortality rate ratio [aMRR], 0.97 per year; 95% CI,. 96-.98), mostly 1999-2010 (aMRR, 0.96 per year; 95% CI,. 95-.97) but was stable 2011-2020 (aMRR, 1.00 per year; 95% CI,. 96-1.05). Mortality due to all known causes except NADM also declined. Conclusions: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts declined between 1999-2009 and was stable over the period 2010-2020. This decline in mortality was not fully explained by improvements in immunologic-virologic status or other risk factors.

Original language	English
Pages (from-to)	1242-1257
Number of pages	16
Journal	Clinical Infectious Diseases
Volume	79
Issue number	5
DOIs	https://doi.org/10.1093/cid/ciae228
Publication status	Published - 15 Nov 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cohort collaboration
HIV
mortality
observational cohort
people with HIV

Access to Document

10.1093/cid/ciae228

Cite this

For the D:A:D Study Group, RESPOND cohort study, Tusch, E., Ryom, L., Pelchen-Matthews, A., Mocroft, A., Elbirt, D., Oprea, C., Günthard, H. F., Staehelin, C., Zangerle, R., Suarez, I., Vehreschild, J. J., Wit, F., Menozzi, M., Monforte, A. D. A., Spagnuolo, V., Pradier, C., Carlander, C., ... Reekie, J. (2024). Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration: A Multicohort Collaboration. Clinical Infectious Diseases, 79(5), 1242-1257. https://doi.org/10.1093/cid/ciae228

@article{48ff23aff2ca46238620061236b3047d,

title = "Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration: A Multicohort Collaboration",

abstract = "Background: Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020. Methods: Data were collected from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) cohort between January 1999 through January 2015 and the International Cohort Consortium of Infectious Disease (RESPOND) from October 2017 through December 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV, were calculated. Poisson models were used to assess mortality over time. Results: Among 55 716 participants followed for median 6 years (interquartile range, 3-11), 5263 died (mortality rate [MR], 13.7/1000 person-years of follow-up [PYFU]; 95\% confidence interval [CI], 13.4-14.1). Changing mortality was observed: AIDS mortality was most common between 1999-2009 (n = 952; MR, 4.2/1000 PYFU; 95\% CI, 4.0-4.5) and non-AIDS-defining malignancy (NADM) between 2010-2020 (n = 444; MR, 2.8/1000 PYFU; 95\% CI, 2.5-3.1). In multivariable analysis, all-cause mortality declined (adjusted mortality rate ratio [aMRR], 0.97 per year; 95\% CI,. 96-.98), mostly 1999-2010 (aMRR, 0.96 per year; 95\% CI,. 95-.97) but was stable 2011-2020 (aMRR, 1.00 per year; 95\% CI,. 96-1.05). Mortality due to all known causes except NADM also declined. Conclusions: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts declined between 1999-2009 and was stable over the period 2010-2020. This decline in mortality was not fully explained by improvements in immunologic-virologic status or other risk factors.",

keywords = "cohort collaboration, HIV, mortality, observational cohort, people with HIV",

author = "\{For the D:A:D Study Group\} and \{RESPOND cohort study\} and Erich Tusch and Lene Ryom and Annegret Pelchen-Matthews and Amanda Mocroft and Daniel Elbirt and Cristiana Oprea and G{\"u}nthard, \{Huldrych F.\} and Cornelia Staehelin and Robert Zangerle and Isabelle Suarez and Vehreschild, \{J{\"o}rg Janne\} and Ferdinand Wit and Marianna Menozzi and Monforte, \{Antonella D.arminio\} and Vincenzo Spagnuolo and Christian Pradier and Christina Carlander and Paula Suanzes and Wasmuth, \{Jan Christian\} and Andrew Carr and Kathy Petoumenos and Frauke Borgans and Fabrice Bonnet and \{De Wit\}, Stephane and Wafaa El-Sadr and Bastian Neesgaard and Nadine Jaschinski and Lauren Greenberg and Hosein, \{Sean R.\} and Joel Gallant and Vani Vannappagari and Lital Young and Caroline Sabin and Jens Lundgren and Lars Peters and Joanne Reekie and W. El-Sadr and G. Calvo and F. Bonnet and F. Dabis and O. Kirk and A. Mocroft and M. Law and \{D'Arminio Monforte\}, A. and L. Morfeldt and C. Pradier and P. Reiss and R. Weber and \{De Wit\}, S. and Ymkje Stienstra",

year = "2024",

month = nov,

day = "15",

doi = "10.1093/cid/ciae228",

language = "English",

volume = "79",

pages = "1242--1257",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "5",

}

For the D:A:D Study Group, RESPOND cohort study, Tusch, E, Ryom, L, Pelchen-Matthews, A, Mocroft, A, Elbirt, D, Oprea, C, Günthard, HF, Staehelin, C, Zangerle, R, Suarez, I, Vehreschild, JJ, Wit, F, Menozzi, M, Monforte, ADA, Spagnuolo, V, Pradier, C, Carlander, C, Suanzes, P, Wasmuth, JC, Carr, A, Petoumenos, K, Borgans, F, Bonnet, F, De Wit, S, El-Sadr, W, Neesgaard, B, Jaschinski, N, Greenberg, L, Hosein, SR, Gallant, J, Vannappagari, V, Young, L, Sabin, C, Lundgren, J, Peters, L & Reekie, J 2024, 'Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration: A Multicohort Collaboration', Clinical Infectious Diseases, vol. 79, no. 5, pp. 1242-1257. https://doi.org/10.1093/cid/ciae228

TY - JOUR

T1 - Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration: A Multicohort Collaboration

AU - For the D:A:D Study Group

AU - RESPOND cohort study

AU - Tusch, Erich

AU - Ryom, Lene

AU - Pelchen-Matthews, Annegret

AU - Mocroft, Amanda

AU - Elbirt, Daniel

AU - Oprea, Cristiana

AU - Günthard, Huldrych F.

AU - Staehelin, Cornelia

AU - Zangerle, Robert

AU - Suarez, Isabelle

AU - Vehreschild, Jörg Janne

AU - Wit, Ferdinand

AU - Menozzi, Marianna

AU - Monforte, Antonella D.arminio

AU - Spagnuolo, Vincenzo

AU - Pradier, Christian

AU - Carlander, Christina

AU - Suanzes, Paula

AU - Wasmuth, Jan Christian

AU - Carr, Andrew

AU - Petoumenos, Kathy

AU - Borgans, Frauke

AU - Bonnet, Fabrice

AU - De Wit, Stephane

AU - El-Sadr, Wafaa

AU - Neesgaard, Bastian

AU - Jaschinski, Nadine

AU - Greenberg, Lauren

AU - Hosein, Sean R.

AU - Gallant, Joel

AU - Vannappagari, Vani

AU - Young, Lital

AU - Sabin, Caroline

AU - Lundgren, Jens

AU - Peters, Lars

AU - Reekie, Joanne

AU - El-Sadr, W.

AU - Calvo, G.

AU - Bonnet, F.

AU - Dabis, F.

AU - Kirk, O.

AU - Mocroft, A.

AU - Law, M.

AU - D'Arminio Monforte, A.

AU - Morfeldt, L.

AU - Pradier, C.

AU - Reiss, P.

AU - Weber, R.

AU - De Wit, S.

AU - Stienstra, Ymkje

PY - 2024/11/15

Y1 - 2024/11/15

N2 - Background: Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020. Methods: Data were collected from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) cohort between January 1999 through January 2015 and the International Cohort Consortium of Infectious Disease (RESPOND) from October 2017 through December 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV, were calculated. Poisson models were used to assess mortality over time. Results: Among 55 716 participants followed for median 6 years (interquartile range, 3-11), 5263 died (mortality rate [MR], 13.7/1000 person-years of follow-up [PYFU]; 95% confidence interval [CI], 13.4-14.1). Changing mortality was observed: AIDS mortality was most common between 1999-2009 (n = 952; MR, 4.2/1000 PYFU; 95% CI, 4.0-4.5) and non-AIDS-defining malignancy (NADM) between 2010-2020 (n = 444; MR, 2.8/1000 PYFU; 95% CI, 2.5-3.1). In multivariable analysis, all-cause mortality declined (adjusted mortality rate ratio [aMRR], 0.97 per year; 95% CI,. 96-.98), mostly 1999-2010 (aMRR, 0.96 per year; 95% CI,. 95-.97) but was stable 2011-2020 (aMRR, 1.00 per year; 95% CI,. 96-1.05). Mortality due to all known causes except NADM also declined. Conclusions: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts declined between 1999-2009 and was stable over the period 2010-2020. This decline in mortality was not fully explained by improvements in immunologic-virologic status or other risk factors.

AB - Background: Mortality among people with human immunodeficiency virus (HIV) declined with the introduction of combination antiretroviral therapy. We investigated trends in mortality in people with HIV from 1999 through 2020. Methods: Data were collected from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) cohort between January 1999 through January 2015 and the International Cohort Consortium of Infectious Disease (RESPOND) from October 2017 through December 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV, were calculated. Poisson models were used to assess mortality over time. Results: Among 55 716 participants followed for median 6 years (interquartile range, 3-11), 5263 died (mortality rate [MR], 13.7/1000 person-years of follow-up [PYFU]; 95% confidence interval [CI], 13.4-14.1). Changing mortality was observed: AIDS mortality was most common between 1999-2009 (n = 952; MR, 4.2/1000 PYFU; 95% CI, 4.0-4.5) and non-AIDS-defining malignancy (NADM) between 2010-2020 (n = 444; MR, 2.8/1000 PYFU; 95% CI, 2.5-3.1). In multivariable analysis, all-cause mortality declined (adjusted mortality rate ratio [aMRR], 0.97 per year; 95% CI,. 96-.98), mostly 1999-2010 (aMRR, 0.96 per year; 95% CI,. 95-.97) but was stable 2011-2020 (aMRR, 1.00 per year; 95% CI,. 96-1.05). Mortality due to all known causes except NADM also declined. Conclusions: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts declined between 1999-2009 and was stable over the period 2010-2020. This decline in mortality was not fully explained by improvements in immunologic-virologic status or other risk factors.

KW - cohort collaboration

KW - HIV

KW - mortality

KW - observational cohort

KW - people with HIV

U2 - 10.1093/cid/ciae228

DO - 10.1093/cid/ciae228

M3 - Article

SN - 1058-4838

VL - 79

SP - 1242

EP - 1257

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 5

ER -

Trends in Mortality in People With HIV From 1999 through 2020: A Multicohort Collaboration: A Multicohort Collaboration

Abstract

UN SDGs

Keywords

Access to Document

Fingerprint

Cite this