Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial

Susan H. Eshleman; Sarah E. Hudelson; Andrew D. Redd; Ronald Swanstrom; San San Ou; Xinyi Cindy Zhang; Li Hua Ping; Estelle Piwowar-Manning; Stephen F. Porcella; Matthew F. Sievers; Craig A. Martens; Daniel Bruno; Elena Dukhovlinova; Marybeth McCauley; Theresa Gamble; Jessica M. Fogel; Devin Sabin; Thomas C. Quinn; Laurence Gunde; Madalitso Maliwichi; Nehemiah Nhando; Victor Akelo; Sikhulile Moyo; Ravindre Panchia; Nagalingeswaran Kumarasamy; Nuntisa Chotirosniramit; Marineide Gonçalves De Melo; Jose Pilotto; Beatriz Grinsztejn; Kenneth Mayer; Ying Q. Chen; James P. Hughes; Myron S. Cohen

doi:10.1097/qai.0000000000001158

Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial

Susan H. Eshleman
, Sarah E. Hudelson
, Andrew D. Redd
, Ronald Swanstrom
, San San Ou
, Xinyi Cindy Zhang
, Li Hua Ping
, Estelle Piwowar-Manning
, Stephen F. Porcella
, Matthew F. Sievers
, Craig A. Martens
, Daniel Bruno
, Elena Dukhovlinova
, Marybeth McCauley
, Theresa Gamble
, Jessica M. Fogel
, Devin Sabin
, Thomas C. Quinn
, Laurence Gunde
, Madalitso Maliwichi

Nehemiah Nhando, Victor Akelo, Sikhulile Moyo, Ravindre Panchia, Nagalingeswaran Kumarasamy, Nuntisa Chotirosniramit, Marineide Gonçalves De Melo, Jose Pilotto, Beatriz Grinsztejn, Kenneth Mayer, Ying Q. Chen, James P. Hughes, Myron S. Cohen

Johns Hopkins University
National Institutes of Health
University of North Carolina at Chapel Hill
Fred Hutchinson Cancer Research Center
FHI 360
Science Facilitation Department
University of Malawi
University of Zimbabwe
Centers for Disease Control and Prevention
Botswana-Harvard AIDS Institute Partnership
University of the Witwatersrand
VHS Medical Centre India
Chiang Mai University
Hospital Nossa Senhora da Conceição
Hospital Geral de Nova Iguacu and Laboratorio de AIDS e Imunologia Molecular-IOC/Fiocruz
Fundação Oswaldo Cruz
Fenway Community Health Center
Beth Israel Deaconess Medical Center
University of Washington

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.

Original language	English
Pages (from-to)	112-116
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes (1999)
Volume	74
Issue number	1
DOIs	https://doi.org/10.1097/qai.0000000000001158
Publication status	Published - 1 Jan 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV-1
HPTN 052
linkage
partner
serodiscordant couples
transmission

Access to Document

10.1097/qai.0000000000001158

Cite this

Eshleman, S. H., Hudelson, S. E., Redd, A. D., Swanstrom, R., Ou, S. S., Zhang, X. C., Ping, L. H., Piwowar-Manning, E., Porcella, S. F., Sievers, M. F., Martens, C. A., Bruno, D., Dukhovlinova, E., McCauley, M., Gamble, T., Fogel, J. M., Sabin, D., Quinn, T. C., Gunde, L., ... Cohen, M. S. (2017). Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial. Journal of Acquired Immune Deficiency Syndromes (1999), 74(1), 112-116. https://doi.org/10.1097/qai.0000000000001158

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title = "Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial",

abstract = "HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.",

keywords = "HIV-1, HPTN 052, linkage, partner, serodiscordant couples, transmission",

author = "Eshleman, \{Susan H.\} and Hudelson, \{Sarah E.\} and Redd, \{Andrew D.\} and Ronald Swanstrom and Ou, \{San San\} and Zhang, \{Xinyi Cindy\} and Ping, \{Li Hua\} and Estelle Piwowar-Manning and Porcella, \{Stephen F.\} and Sievers, \{Matthew F.\} and Martens, \{Craig A.\} and Daniel Bruno and Elena Dukhovlinova and Marybeth McCauley and Theresa Gamble and Fogel, \{Jessica M.\} and Devin Sabin and Quinn, \{Thomas C.\} and Laurence Gunde and Madalitso Maliwichi and Nehemiah Nhando and Victor Akelo and Sikhulile Moyo and Ravindre Panchia and Nagalingeswaran Kumarasamy and Nuntisa Chotirosniramit and Melo, \{Marineide Gon{\c c}alves De\} and Jose Pilotto and Beatriz Grinsztejn and Kenneth Mayer and Chen, \{Ying Q.\} and Hughes, \{James P.\} and Cohen, \{Myron S.\}",

year = "2017",

month = jan,

day = "1",

doi = "10.1097/qai.0000000000001158",

language = "English",

volume = "74",

pages = "112--116",

journal = "Journal of Acquired Immune Deficiency Syndromes (1999)",

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Eshleman, SH, Hudelson, SE, Redd, AD, Swanstrom, R, Ou, SS, Zhang, XC, Ping, LH, Piwowar-Manning, E, Porcella, SF, Sievers, MF, Martens, CA, Bruno, D, Dukhovlinova, E, McCauley, M, Gamble, T, Fogel, JM, Sabin, D, Quinn, TC, Gunde, L, Maliwichi, M, Nhando, N, Akelo, V, Moyo, S, Panchia, R, Kumarasamy, N, Chotirosniramit, N, Melo, MGD, Pilotto, J, Grinsztejn, B, Mayer, K, Chen, YQ, Hughes, JP & Cohen, MS 2017, 'Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial', Journal of Acquired Immune Deficiency Syndromes (1999), vol. 74, no. 1, pp. 112-116. https://doi.org/10.1097/qai.0000000000001158

Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial. / Eshleman, Susan H.; Hudelson, Sarah E.; Redd, Andrew D. et al.
In: Journal of Acquired Immune Deficiency Syndromes (1999), Vol. 74, No. 1, 01.01.2017, p. 112-116.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial

AU - Eshleman, Susan H.

AU - Hudelson, Sarah E.

AU - Redd, Andrew D.

AU - Swanstrom, Ronald

AU - Ou, San San

AU - Zhang, Xinyi Cindy

AU - Ping, Li Hua

AU - Piwowar-Manning, Estelle

AU - Porcella, Stephen F.

AU - Sievers, Matthew F.

AU - Martens, Craig A.

AU - Bruno, Daniel

AU - Dukhovlinova, Elena

AU - McCauley, Marybeth

AU - Gamble, Theresa

AU - Fogel, Jessica M.

AU - Sabin, Devin

AU - Quinn, Thomas C.

AU - Gunde, Laurence

AU - Maliwichi, Madalitso

AU - Nhando, Nehemiah

AU - Akelo, Victor

AU - Moyo, Sikhulile

AU - Panchia, Ravindre

AU - Kumarasamy, Nagalingeswaran

AU - Chotirosniramit, Nuntisa

AU - Melo, Marineide Gonçalves De

AU - Pilotto, Jose

AU - Grinsztejn, Beatriz

AU - Mayer, Kenneth

AU - Chen, Ying Q.

AU - Hughes, James P.

AU - Cohen, Myron S.

PY - 2017/1/1

Y1 - 2017/1/1

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AB - HIV Prevention Trials Network 052 demonstrated that antiretroviral therapy (ART) prevents HIV transmission in serodiscordant couples. HIV from index-partner pairs was analyzed to determine the genetic linkage status of partner infections. Forty-six infections were classified as linked, indicating that the index was the likely source of the partner's infection. Lack of viral suppression and higher index viral load were associated with linked infection. Eight linked infections were diagnosed after the index started ART: 4 near the time of ART initiation and 4 after ART failure. Linked infections were not observed when the index participant was stably suppressed on ART.

KW - HIV-1

KW - HPTN 052

KW - linkage

KW - partner

KW - serodiscordant couples

KW - transmission

U2 - 10.1097/qai.0000000000001158

DO - 10.1097/qai.0000000000001158

M3 - Article

SN - 1525-4135

VL - 74

SP - 112

EP - 116

JO - Journal of Acquired Immune Deficiency Syndromes (1999)

JF - Journal of Acquired Immune Deficiency Syndromes (1999)

IS - 1

ER -

Eshleman SH, Hudelson SE, Redd AD, Swanstrom R, Ou SS, Zhang XC et al. Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial. Journal of Acquired Immune Deficiency Syndromes (1999). 2017 Jan 1;74(1):112-116. doi: 10.1097/qai.0000000000001158

Treatment as Prevention: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial: Characterization of Partner Infections in the HIV Prevention Trials Network 052 Trial

Abstract

UN SDGs

Keywords

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