Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial

Carolyn Macfadyen; Carrol Gamble; Paul Garner; Isaac Macharia; Ian Mackenzie; Peter Mugwe; Herbert Oburra; Kennedy Otwombe; Stephen Taylor; Paula Williamson

doi:10.1111/j.1365-3156.2004.01368.x

Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial

Carolyn Macfadyen, Carrol Gamble, Paul Garner, Isaac Macharia, Ian Mackenzie, Peter Mugwe, Herbert Oburra, Kennedy Otwombe, Stephen Taylor, Paula Williamson

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE To compare a topical quinolone antibiotic (ciprofloxacin) with a cheaper topical antiseptic (boric acid) for treating chronic suppurative otitis media in children. DESIGN Randomized controlled trial.

SETTING AND PARTICIPANTS A total of 427 children with chronic suppurative otitis media enrolled from 141 schools following screening of 39 841 schoolchildren in Kenya.

INTERVENTION Topical ciprofloxacin (n = 216) or boric acid in alcohol (n = 211); child-to-child treatment twice daily for 2 weeks.

MAIN OUTCOME MEASURES Resolution of discharge (at 2 weeks for primary outcome), healing of the tympanic membrane, and change in hearing threshold from baseline, all at 2 and 4 weeks.

RESULTS At 2 weeks, discharge was resolved in 123 of 207 (59%) children given ciprofloxacin, and in 65 of 204 (32%) given boric acid (relative risk 1.86; 95% CI 1.48-2.35; P < 0.0001). This effect was also significant at 4 weeks, and ciprofloxacin was associated with better hearing at both visits. No difference with respect to tympanic membrane healing was detected. There were significantly fewer adverse events of ear pain, irritation, and bleeding on mopping with ciprofloxacin than boric acid.

CONCLUSIONS Ciprofloxacin performed better than boric acid and alcohol for treating chronic suppurative otitis media in children in Kenya.

Original language	English
Pages (from-to)	190-197
Number of pages	8
Journal	Tropical Medicine and International Health
Volume	10
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-3156.2004.01368.x
Publication status	Published - 1 Feb 2005

Keywords

Antiseptics
Developing countries
Drug
Eardrops
Fluoroquinolones
Hearing impairment
Instillation
Otitis media
Randomized controlled trial
Suppurative

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10.1111/j.1365-3156.2004.01368.x

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title = "Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial",

abstract = "OBJECTIVE To compare a topical quinolone antibiotic (ciprofloxacin) with a cheaper topical antiseptic (boric acid) for treating chronic suppurative otitis media in children. DESIGN Randomized controlled trial.SETTING AND PARTICIPANTS A total of 427 children with chronic suppurative otitis media enrolled from 141 schools following screening of 39 841 schoolchildren in Kenya.INTERVENTION Topical ciprofloxacin (n = 216) or boric acid in alcohol (n = 211); child-to-child treatment twice daily for 2 weeks.MAIN OUTCOME MEASURES Resolution of discharge (at 2 weeks for primary outcome), healing of the tympanic membrane, and change in hearing threshold from baseline, all at 2 and 4 weeks.RESULTS At 2 weeks, discharge was resolved in 123 of 207 (59\%) children given ciprofloxacin, and in 65 of 204 (32\%) given boric acid (relative risk 1.86; 95\% CI 1.48-2.35; P < 0.0001). This effect was also significant at 4 weeks, and ciprofloxacin was associated with better hearing at both visits. No difference with respect to tympanic membrane healing was detected. There were significantly fewer adverse events of ear pain, irritation, and bleeding on mopping with ciprofloxacin than boric acid.CONCLUSIONS Ciprofloxacin performed better than boric acid and alcohol for treating chronic suppurative otitis media in children in Kenya.",

keywords = "Antiseptics, Developing countries, Drug, Eardrops, Fluoroquinolones, Hearing impairment, Instillation, Otitis media, Randomized controlled trial, Suppurative",

author = "Carolyn Macfadyen and Carrol Gamble and Paul Garner and Isaac Macharia and Ian Mackenzie and Peter Mugwe and Herbert Oburra and Kennedy Otwombe and Stephen Taylor and Paula Williamson",

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doi = "10.1111/j.1365-3156.2004.01368.x",

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T1 - Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial

AU - Macfadyen, Carolyn

AU - Gamble, Carrol

AU - Garner, Paul

AU - Macharia, Isaac

AU - Mackenzie, Ian

AU - Mugwe, Peter

AU - Oburra, Herbert

AU - Otwombe, Kennedy

AU - Taylor, Stephen

AU - Williamson, Paula

PY - 2005/2/1

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N2 - OBJECTIVE To compare a topical quinolone antibiotic (ciprofloxacin) with a cheaper topical antiseptic (boric acid) for treating chronic suppurative otitis media in children. DESIGN Randomized controlled trial.SETTING AND PARTICIPANTS A total of 427 children with chronic suppurative otitis media enrolled from 141 schools following screening of 39 841 schoolchildren in Kenya.INTERVENTION Topical ciprofloxacin (n = 216) or boric acid in alcohol (n = 211); child-to-child treatment twice daily for 2 weeks.MAIN OUTCOME MEASURES Resolution of discharge (at 2 weeks for primary outcome), healing of the tympanic membrane, and change in hearing threshold from baseline, all at 2 and 4 weeks.RESULTS At 2 weeks, discharge was resolved in 123 of 207 (59%) children given ciprofloxacin, and in 65 of 204 (32%) given boric acid (relative risk 1.86; 95% CI 1.48-2.35; P < 0.0001). This effect was also significant at 4 weeks, and ciprofloxacin was associated with better hearing at both visits. No difference with respect to tympanic membrane healing was detected. There were significantly fewer adverse events of ear pain, irritation, and bleeding on mopping with ciprofloxacin than boric acid.CONCLUSIONS Ciprofloxacin performed better than boric acid and alcohol for treating chronic suppurative otitis media in children in Kenya.

AB - OBJECTIVE To compare a topical quinolone antibiotic (ciprofloxacin) with a cheaper topical antiseptic (boric acid) for treating chronic suppurative otitis media in children. DESIGN Randomized controlled trial.SETTING AND PARTICIPANTS A total of 427 children with chronic suppurative otitis media enrolled from 141 schools following screening of 39 841 schoolchildren in Kenya.INTERVENTION Topical ciprofloxacin (n = 216) or boric acid in alcohol (n = 211); child-to-child treatment twice daily for 2 weeks.MAIN OUTCOME MEASURES Resolution of discharge (at 2 weeks for primary outcome), healing of the tympanic membrane, and change in hearing threshold from baseline, all at 2 and 4 weeks.RESULTS At 2 weeks, discharge was resolved in 123 of 207 (59%) children given ciprofloxacin, and in 65 of 204 (32%) given boric acid (relative risk 1.86; 95% CI 1.48-2.35; P < 0.0001). This effect was also significant at 4 weeks, and ciprofloxacin was associated with better hearing at both visits. No difference with respect to tympanic membrane healing was detected. There were significantly fewer adverse events of ear pain, irritation, and bleeding on mopping with ciprofloxacin than boric acid.CONCLUSIONS Ciprofloxacin performed better than boric acid and alcohol for treating chronic suppurative otitis media in children in Kenya.

KW - Antiseptics

KW - Developing countries

KW - Drug

KW - Eardrops

KW - Fluoroquinolones

KW - Hearing impairment

KW - Instillation

KW - Otitis media

KW - Randomized controlled trial

KW - Suppurative

U2 - 10.1111/j.1365-3156.2004.01368.x

DO - 10.1111/j.1365-3156.2004.01368.x

M3 - Article

SN - 1360-2276

VL - 10

SP - 190

EP - 197

JO - Tropical Medicine and International Health

JF - Tropical Medicine and International Health

IS - 2

ER -

Topical quinolone vs. antiseptic for treating chronic suppurative otitis media: a randomized controlled trial

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Keywords

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