Toll-like receptor polymorphisms in malaria-endemic populations.

Jennifer A. Greene; Ann M. Moormann; John Vulule; Moses Bockarie; Peter A. Zimmerman; James W. Kazura

doi:10.1186/1475-2875-8-50

Toll-like receptor polymorphisms in malaria-endemic populations.

Jennifer A. Greene, Ann M. Moormann, John Vulule, Moses Bockarie, Peter A. Zimmerman, James W. Kazura

Liverpool School of Tropical Medicine

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Similar frequencies of TLR2, TLR4, TLR9, and MAL genetic polymorphisms in populations with different histories of malaria exposure suggest that these innate immune pathways have not been under strong selective pressure by malaria. Genotype frequencies are consistent with Hardy-Weinberg Equilibrium and the Neutral Theory, suggesting that genetic drift has influenced allele frequencies to a greater extent than selective pressure from malaria or any other infectious agents in these populations.

Original language	English
Article number	50
Pages (from-to)	50
Journal	Malaria Journal
Volume	8
Issue number	1
DOIs	https://doi.org/10.1186/1475-2875-8-50
Publication status	Published - 24 Mar 2009

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title = "Toll-like receptor polymorphisms in malaria-endemic populations.",

abstract = "Similar frequencies of TLR2, TLR4, TLR9, and MAL genetic polymorphisms in populations with different histories of malaria exposure suggest that these innate immune pathways have not been under strong selective pressure by malaria. Genotype frequencies are consistent with Hardy-Weinberg Equilibrium and the Neutral Theory, suggesting that genetic drift has influenced allele frequencies to a greater extent than selective pressure from malaria or any other infectious agents in these populations.",

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AU - Kazura, James W.

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AB - Similar frequencies of TLR2, TLR4, TLR9, and MAL genetic polymorphisms in populations with different histories of malaria exposure suggest that these innate immune pathways have not been under strong selective pressure by malaria. Genotype frequencies are consistent with Hardy-Weinberg Equilibrium and the Neutral Theory, suggesting that genetic drift has influenced allele frequencies to a greater extent than selective pressure from malaria or any other infectious agents in these populations.

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Toll-like receptor polymorphisms in malaria-endemic populations.

Abstract

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