Timing of Screening Benefit for Lung Cancer With Low-Dose CT Imaging

Yang Xie; Yiyin Zhang; Peng Zhang; Yiting Li; Baichuan Xu; Fang Shao; Yingying Zhang; Tian Yang; Jiansheng Li; Chao Li; Tao Chen

doi:10.1016/j.chest.2025.06.012

Timing of Screening Benefit for Lung Cancer With Low-Dose CT Imaging

Yang Xie
, Yiyin Zhang
, Peng Zhang
, Yiting Li
, Baichuan Xu
, Fang Shao
, Yingying Zhang
, Tian Yang
, Jiansheng Li
, Chao Li
, Tao Chen

Clinical Sciences

Henan University of Chinese Medicine
Nanjing Medical University
University of York
First Affiliated Hospital of Xi 'An Jiaotong University
Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background
Increasing evidence supports lung cancer screening with low-dose CT (LDCT) imaging. However, the benefits of LDCT screening for lung cancer may not be immediate, making it unlikely to benefit patients with limited life expectancy.
Research Question
What is the time to benefit (TTB) from LDCT screening for individuals at high risk for lung cancer?

Original language	English
Pages (from-to)	1049-1056
Number of pages	8
Journal	Chest
Volume	168
Issue number	4
Early online date	18 Jun 2025
DOIs	https://doi.org/10.1016/j.chest.2025.06.012
Publication status	Published - 1 Oct 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

clinical benefit
low-dose CT
lung cancer
screening

Access to Document

10.1016/j.chest.2025.06.012

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Main_text_for_production_CHEST
Accepted author manuscript, 222 KB
Licence: CC BY-NC-ND
Embargo ends: 18/06/26

Cite this

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title = "Timing of Screening Benefit for Lung Cancer With Low-Dose CT Imaging",

abstract = "Background Increasing evidence supports lung cancer screening with low-dose CT (LDCT) imaging. However, the benefits of LDCT screening for lung cancer may not be immediate, making it unlikely to benefit patients with limited life expectancy. Research Question What is the time to benefit (TTB) from LDCT screening for individuals at high risk for lung cancer?",

keywords = "clinical benefit, low-dose CT, lung cancer, screening",

author = "Yang Xie and Yiyin Zhang and Peng Zhang and Yiting Li and Baichuan Xu and Fang Shao and Yingying Zhang and Tian Yang and Jiansheng Li and Chao Li and Tao Chen",

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T1 - Timing of Screening Benefit for Lung Cancer With Low-Dose CT Imaging

AU - Xie, Yang

AU - Zhang, Yiyin

AU - Zhang, Peng

AU - Li, Yiting

AU - Xu, Baichuan

AU - Shao, Fang

AU - Zhang, Yingying

AU - Yang, Tian

AU - Li, Jiansheng

AU - Li, Chao

AU - Chen, Tao

PY - 2025/10/1

Y1 - 2025/10/1

N2 - Background Increasing evidence supports lung cancer screening with low-dose CT (LDCT) imaging. However, the benefits of LDCT screening for lung cancer may not be immediate, making it unlikely to benefit patients with limited life expectancy. Research Question What is the time to benefit (TTB) from LDCT screening for individuals at high risk for lung cancer?

AB - Background Increasing evidence supports lung cancer screening with low-dose CT (LDCT) imaging. However, the benefits of LDCT screening for lung cancer may not be immediate, making it unlikely to benefit patients with limited life expectancy. Research Question What is the time to benefit (TTB) from LDCT screening for individuals at high risk for lung cancer?

KW - clinical benefit

KW - low-dose CT

KW - lung cancer

KW - screening

U2 - 10.1016/j.chest.2025.06.012

DO - 10.1016/j.chest.2025.06.012

M3 - Article

SN - 0012-3692

VL - 168

SP - 1049

EP - 1056

JO - Chest

JF - Chest

IS - 4

ER -

Timing of Screening Benefit for Lung Cancer With Low-Dose CT Imaging

Abstract

UN SDGs

Keywords

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