Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Alexis M. Nzila; Gilbert Kokwaro; Peter A. Winstanley; Kevin Marsh; Steve Ward

doi:10.1016/j.pt.2003.12.005

Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Alexis M. Nzila
, Gilbert Kokwaro
, Peter A. Winstanley
, Kevin Marsh
, Steve Ward

Tropical Disease Biology

Research output: Contribution to journal › Short survey › peer-review

17 Citations (Scopus)

Abstract

Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

Original language	English
Pages (from-to)	109-112
Number of pages	4
Journal	Trends In Parasitology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.pt.2003.12.005
Publication status	Published - 1 Mar 2004

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10.1016/j.pt.2003.12.005

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title = "Therapeutic potential of folate uptake inhibition in Plasmodium falciparum",

abstract = "Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.",

author = "Nzila, \{Alexis M.\} and Gilbert Kokwaro and Winstanley, \{Peter A.\} and Kevin Marsh and Steve Ward",

year = "2004",

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doi = "10.1016/j.pt.2003.12.005",

language = "English",

volume = "20",

pages = "109--112",

journal = "Trends In Parasitology",

issn = "1471-4922",

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TY - JOUR

T1 - Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

AU - Nzila, Alexis M.

AU - Kokwaro, Gilbert

AU - Winstanley, Peter A.

AU - Marsh, Kevin

AU - Ward, Steve

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

AB - Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

U2 - 10.1016/j.pt.2003.12.005

DO - 10.1016/j.pt.2003.12.005

M3 - Short survey

SN - 1471-4922

VL - 20

SP - 109

EP - 112

JO - Trends In Parasitology

JF - Trends In Parasitology

IS - 3

ER -

Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Abstract

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