The Wolbachia Bacterial Endosymbionts of Filarial Nematodes

Jeremy M. Foster; Achim Hoerauf; Barton E. Slatko; Mark Taylor

doi:10.1079/9781845937591.0000

The Wolbachia Bacterial Endosymbionts of Filarial Nematodes

Jeremy M. Foster, Achim Hoerauf, Barton E. Slatko, Mark Taylor

Tropical Disease Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This chapter discusses the symbiotic relationship between Wolbachia and filarial nematodes as indicated by antibiotic treatments and the combined analyses of the completed genomes of Wolbachia and its Brugia malayi host. Potential mechanisms that explain how Wolbachia activate innate and adaptive inflammatory responses associated with driving disease pathogenesis are described, as well as relevant molecular ligands and immunological pathways leading to disease pathogenesis.

Original language	English
Title of host publication	Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology, 2nd Edition
Editors	M.W. Kennedy, W. Harnett
Pages	308-336
DOIs	https://doi.org/10.1079/9781845937591.0000
Publication status	Published - 1 Jan 2013

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abstract = "This chapter discusses the symbiotic relationship between Wolbachia and filarial nematodes as indicated by antibiotic treatments and the combined analyses of the completed genomes of Wolbachia and its Brugia malayi host. Potential mechanisms that explain how Wolbachia activate innate and adaptive inflammatory responses associated with driving disease pathogenesis are described, as well as relevant molecular ligands and immunological pathways leading to disease pathogenesis.",

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AB - This chapter discusses the symbiotic relationship between Wolbachia and filarial nematodes as indicated by antibiotic treatments and the combined analyses of the completed genomes of Wolbachia and its Brugia malayi host. Potential mechanisms that explain how Wolbachia activate innate and adaptive inflammatory responses associated with driving disease pathogenesis are described, as well as relevant molecular ligands and immunological pathways leading to disease pathogenesis.

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The Wolbachia Bacterial Endosymbionts of Filarial Nematodes

Abstract

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