The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial

Chunxiao Zhang; Yaguang Zheng; Tao Chen; Shengyu Wang; Meng Xu

doi:10.1016/j.ctim.2019.102203

The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial

Chunxiao Zhang, Yaguang Zheng, Tao Chen, Shengyu Wang, Meng Xu

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Objective

examine the efficacy and safety of Shenmai to the cardiac rehabilitation in patients received coronary artery bypass grafting.

Design

a single-center randomized, single blind clinical trial.

Setting

Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Subjects

Patients with coronary artery disease who received coronary artery bypass grafting in our center were studied. They must be competent to complete the 6-minute walking test without any assistance and without any severe comorbidity.

Interventions

in Shemmai group, the participants were treated with Shenmai injection (100 ml/day) right after the surgery to discharge for 9.28 ± 3.75 days and then capsule (3.6 g/day) sequentially for 30 days in addition to the cardiac rehabilitation. In control group, only cardiac rehabilitation was conducted.

Main measures

the 6-Minute Walking Test was measured at three time points: one day before operation, on the day of discharge and 30 days follow up.

Results

The sample (n = 166) was predominately male (84%), with mean age was 61.12 ± 9.13 years. There was no significant difference between groups in baseline characteristics and the procedural characteristics. There was one death in control group and one stroke in Shenmai group right after the surgery. Overall, there was group (p = .005) and time effect (p < .001) on the 6-minute walking distance. Participants in the Shenmai group walked longer distance in meters compared with control group on the day of discharge (314.54 ± 64.14 vs. 271.29 ± 76.82, P < .001), while no significant differences before operation (399.72 ± 93.19 vs. 403.67 ± 91.99, p = .78) and on 30-day follow up (436.54 ± 67.64 vs. 421.64 ± 83.53, p = .21).

Conclusion

Shenmai improves the exercise tolerance in the early stage of the cardiac rehabilitation for patients received coronary artery bypass grafting.

Original language	English
Article number	102203
Journal	Complementary Therapies in Medicine
Volume	47
Early online date	10 Oct 2019
DOIs	https://doi.org/10.1016/j.ctim.2019.102203
Publication status	E-pub ahead of print - 10 Oct 2019

Keywords

6-minute walking test
Cardiac rehabilitation
Coronary artery bypass grafting
Randomized clinical trial
Shenmai

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10.1016/j.ctim.2019.102203

The Utility of Traditional Chinese Medicine (Shenmai) in the Cardiac Rehabilitation after Coronary Artery Bypass Grafting a Single-Center Randomized Clin (002)Accepted author manuscript, 386 KB

Cite this

@article{a269ac6fb8214b978ac67d756fece138,

title = "The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial",

abstract = "Objectiveexamine the efficacy and safety of Shenmai to the cardiac rehabilitation in patients received coronary artery bypass grafting.Designa single-center randomized, single blind clinical trial.SettingDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.SubjectsPatients with coronary artery disease who received coronary artery bypass grafting in our center were studied. They must be competent to complete the 6-minute walking test without any assistance and without any severe comorbidity.Interventionsin Shemmai group, the participants were treated with Shenmai injection (100 ml/day) right after the surgery to discharge for 9.28 ± 3.75 days and then capsule (3.6 g/day) sequentially for 30 days in addition to the cardiac rehabilitation. In control group, only cardiac rehabilitation was conducted.Main measuresthe 6-Minute Walking Test was measured at three time points: one day before operation, on the day of discharge and 30 days follow up.ResultsThe sample (n = 166) was predominately male (84\%), with mean age was 61.12 ± 9.13 years. There was no significant difference between groups in baseline characteristics and the procedural characteristics. There was one death in control group and one stroke in Shenmai group right after the surgery. Overall, there was group (p = .005) and time effect (p < .001) on the 6-minute walking distance. Participants in the Shenmai group walked longer distance in meters compared with control group on the day of discharge (314.54 ± 64.14 vs. 271.29 ± 76.82, P < .001), while no significant differences before operation (399.72 ± 93.19 vs. 403.67 ± 91.99, p = .78) and on 30-day follow up (436.54 ± 67.64 vs. 421.64 ± 83.53, p = .21).ConclusionShenmai improves the exercise tolerance in the early stage of the cardiac rehabilitation for patients received coronary artery bypass grafting.",

keywords = "6-minute walking test, Cardiac rehabilitation, Coronary artery bypass grafting, Randomized clinical trial, Shenmai",

author = "Chunxiao Zhang and Yaguang Zheng and Tao Chen and Shengyu Wang and Meng Xu",

year = "2019",

month = oct,

day = "10",

doi = "10.1016/j.ctim.2019.102203",

language = "English",

volume = "47",

journal = "Complementary Therapies in Medicine",

issn = "0965-2299",

publisher = "Churchill Livingstone",

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TY - JOUR

T1 - The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial

AU - Zhang, Chunxiao

AU - Zheng, Yaguang

AU - Chen, Tao

AU - Wang, Shengyu

AU - Xu, Meng

PY - 2019/10/10

Y1 - 2019/10/10

N2 - Objectiveexamine the efficacy and safety of Shenmai to the cardiac rehabilitation in patients received coronary artery bypass grafting.Designa single-center randomized, single blind clinical trial.SettingDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.SubjectsPatients with coronary artery disease who received coronary artery bypass grafting in our center were studied. They must be competent to complete the 6-minute walking test without any assistance and without any severe comorbidity.Interventionsin Shemmai group, the participants were treated with Shenmai injection (100 ml/day) right after the surgery to discharge for 9.28 ± 3.75 days and then capsule (3.6 g/day) sequentially for 30 days in addition to the cardiac rehabilitation. In control group, only cardiac rehabilitation was conducted.Main measuresthe 6-Minute Walking Test was measured at three time points: one day before operation, on the day of discharge and 30 days follow up.ResultsThe sample (n = 166) was predominately male (84%), with mean age was 61.12 ± 9.13 years. There was no significant difference between groups in baseline characteristics and the procedural characteristics. There was one death in control group and one stroke in Shenmai group right after the surgery. Overall, there was group (p = .005) and time effect (p < .001) on the 6-minute walking distance. Participants in the Shenmai group walked longer distance in meters compared with control group on the day of discharge (314.54 ± 64.14 vs. 271.29 ± 76.82, P < .001), while no significant differences before operation (399.72 ± 93.19 vs. 403.67 ± 91.99, p = .78) and on 30-day follow up (436.54 ± 67.64 vs. 421.64 ± 83.53, p = .21).ConclusionShenmai improves the exercise tolerance in the early stage of the cardiac rehabilitation for patients received coronary artery bypass grafting.

AB - Objectiveexamine the efficacy and safety of Shenmai to the cardiac rehabilitation in patients received coronary artery bypass grafting.Designa single-center randomized, single blind clinical trial.SettingDepartment of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.SubjectsPatients with coronary artery disease who received coronary artery bypass grafting in our center were studied. They must be competent to complete the 6-minute walking test without any assistance and without any severe comorbidity.Interventionsin Shemmai group, the participants were treated with Shenmai injection (100 ml/day) right after the surgery to discharge for 9.28 ± 3.75 days and then capsule (3.6 g/day) sequentially for 30 days in addition to the cardiac rehabilitation. In control group, only cardiac rehabilitation was conducted.Main measuresthe 6-Minute Walking Test was measured at three time points: one day before operation, on the day of discharge and 30 days follow up.ResultsThe sample (n = 166) was predominately male (84%), with mean age was 61.12 ± 9.13 years. There was no significant difference between groups in baseline characteristics and the procedural characteristics. There was one death in control group and one stroke in Shenmai group right after the surgery. Overall, there was group (p = .005) and time effect (p < .001) on the 6-minute walking distance. Participants in the Shenmai group walked longer distance in meters compared with control group on the day of discharge (314.54 ± 64.14 vs. 271.29 ± 76.82, P < .001), while no significant differences before operation (399.72 ± 93.19 vs. 403.67 ± 91.99, p = .78) and on 30-day follow up (436.54 ± 67.64 vs. 421.64 ± 83.53, p = .21).ConclusionShenmai improves the exercise tolerance in the early stage of the cardiac rehabilitation for patients received coronary artery bypass grafting.

KW - 6-minute walking test

KW - Cardiac rehabilitation

KW - Coronary artery bypass grafting

KW - Randomized clinical trial

KW - Shenmai

U2 - 10.1016/j.ctim.2019.102203

DO - 10.1016/j.ctim.2019.102203

M3 - Article

SN - 0965-2299

VL - 47

JO - Complementary Therapies in Medicine

JF - Complementary Therapies in Medicine

M1 - 102203

ER -

The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial

Abstract

Keywords

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