The role of ICAM-1 in Plasmodium falciparum cytoadherence

Srabasti J. Chakravorty; Alister Craig

doi:10.1016/j.ejcb.2004.09.002

The role of ICAM-1 in Plasmodium falciparum cytoadherence

Srabasti J. Chakravorty, Alister Craig

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Review article › peer-review

90 Citations (Scopus)

Abstract

Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the vascular endothelium. We highlight the nature of the interaction between ICAM-1 and the parasite-expressed PfEMP-1 molecule at the molecular level. The review also discusses the complexity of the PRBC-endothelial cell interaction band the mechanisms that underlie parasite cytoadherence. (C) 2004 Elsevier GmbH. All rights reserved.

Original language	English
Pages (from-to)	15-27
Number of pages	13
Journal	European Journal of Cell Biology
Volume	84
Issue number	1
DOIs	https://doi.org/10.1016/j.ejcb.2004.09.002
Publication status	Published - 31 Jan 2005

Keywords

Adhesion
Endothelial cell
Intercellular adhesion molecule-1 (ICAM-1)
Plasmodium falciparum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejcb.2004.09.002

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title = "The role of ICAM-1 in Plasmodium falciparum cytoadherence",

abstract = "Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the vascular endothelium. We highlight the nature of the interaction between ICAM-1 and the parasite-expressed PfEMP-1 molecule at the molecular level. The review also discusses the complexity of the PRBC-endothelial cell interaction band the mechanisms that underlie parasite cytoadherence. (C) 2004 Elsevier GmbH. All rights reserved.",

keywords = "Adhesion, Endothelial cell, Intercellular adhesion molecule-1 (ICAM-1), Plasmodium falciparum",

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T1 - The role of ICAM-1 in Plasmodium falciparum cytoadherence

AU - Chakravorty, Srabasti J.

AU - Craig, Alister

PY - 2005/1/31

Y1 - 2005/1/31

N2 - Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the vascular endothelium. We highlight the nature of the interaction between ICAM-1 and the parasite-expressed PfEMP-1 molecule at the molecular level. The review also discusses the complexity of the PRBC-endothelial cell interaction band the mechanisms that underlie parasite cytoadherence. (C) 2004 Elsevier GmbH. All rights reserved.

AB - Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the vascular endothelium. We highlight the nature of the interaction between ICAM-1 and the parasite-expressed PfEMP-1 molecule at the molecular level. The review also discusses the complexity of the PRBC-endothelial cell interaction band the mechanisms that underlie parasite cytoadherence. (C) 2004 Elsevier GmbH. All rights reserved.

KW - Adhesion

KW - Endothelial cell

KW - Intercellular adhesion molecule-1 (ICAM-1)

KW - Plasmodium falciparum

U2 - 10.1016/j.ejcb.2004.09.002

DO - 10.1016/j.ejcb.2004.09.002

M3 - Review article

SN - 0171-9335

VL - 84

SP - 15

EP - 27

JO - European Journal of Cell Biology

JF - European Journal of Cell Biology

IS - 1

ER -

The role of ICAM-1 in Plasmodium falciparum cytoadherence

Abstract

Keywords

UN SDGs

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