The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness

A. S. Andre; N. M. Blackwell; L. R. Hall; A. Hoerauf; N. W. Bratting; L. Volkmann; Mark Taylor; Louise Ford; A. G. Hise; J. H. Lass; E. Diaconu; E. Pearlman

doi:10.1126/science.1068732

The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness

A. S. Andre, N. M. Blackwell, L. R. Hall, A. Hoerauf, N. W. Bratting, L. Volkmann, Mark Taylor, Louise Ford, A. G. Hise, J. H. Lass, E. Diaconu, E. Pearlman

Tropical Disease Biology

Case Western Reserve University

Research output: Contribution to journal › Article › peer-review

333 Citations (Scopus)

Abstract

Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells.

Original language	English
Pages (from-to)	1892-1895
Number of pages	4
Journal	Science
Volume	295
Issue number	5561
DOIs	https://doi.org/10.1126/science.1068732
Publication status	Published - 8 Mar 2002

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title = "The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness",

abstract = "Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells.",

author = "Andre, \{A. S.\} and Blackwell, \{N. M.\} and Hall, \{L. R.\} and A. Hoerauf and Bratting, \{N. W.\} and L. Volkmann and Mark Taylor and Louise Ford and Hise, \{A. G.\} and Lass, \{J. H.\} and E. Diaconu and E. Pearlman",

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T1 - The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness

AU - Andre, A. S.

AU - Blackwell, N. M.

AU - Hall, L. R.

AU - Hoerauf, A.

AU - Bratting, N. W.

AU - Volkmann, L.

AU - Taylor, Mark

AU - Ford, Louise

AU - Hise, A. G.

AU - Lass, J. H.

AU - Diaconu, E.

AU - Pearlman, E.

PY - 2002/3/8

Y1 - 2002/3/8

N2 - Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells.

AB - Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells.

U2 - 10.1126/science.1068732

DO - 10.1126/science.1068732

M3 - Article

SN - 0036-8075

VL - 295

SP - 1892

EP - 1895

JO - Science

JF - Science

IS - 5561

ER -

The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness

Abstract

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