TY - JOUR
T1 - The rapidly increasing incidence of type 2 diabetes and macrovascular and microvascular complications disproportionately affects younger age groups: A decade of evidence from an international federated database
AU - Anson, Matthew
AU - Henney, Alex E.
AU - Edwards, Harry
AU - Ibarburu, Gema H.
AU - Mordi, Ify
AU - Jaffar, Shabbar
AU - Garrib, Anupam
AU - Lip, Gregory Y.H.
AU - Wang, Duolao
AU - Nabrdalik, Katarzyna
AU - Perkins, Bruce A.
AU - Cuthbertson, Daniel J.
AU - Alam, Uazman
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/10/1
Y1 - 2025/10/1
N2 - Aims: To characterise recent trends in incidence and prevalence of type 2 diabetes (T2D) associated complications, and their relative impact across the lifespan. Methods: We conducted a retrospective cohort study using the TriNetX global federated database. Incidence and prevalence of T2D and associated complications: ischaemic heart disease (IHD), heart failure, cerebral infarction, neuropathy, nephropathy, and retinopathy were assessed between 2012 and 2023. Incidence odds ratios (IOR) were calculated by age group. Results: 7,918,666 individuals had T2D. The IOR (95 % CI), comparing individuals aged ≥ 85 years to < 35 years decreased for all complications from 2012 to 2023: IHD [IOR 6.82, (6.40, 7.26) to IOR 2.27 (2.17, 2.38)], heart failure [IOR 5.38, (5.03, 5.75) to IOR 1.80 (1.72, 1.89)], cerebral infarction [IOR 3.06, (2.76, 3.40) to IOR 1.45 (1.34, 1.57)], neuropathy [IOR 0.84, (0.74, 0.95) to IOR 0.47 (0.44, 0.49)], nephropathy [IOR 1.14, (1.03, 1.27) to IOR 0.90 (0.87, 0.94)] and retinopathy [IOR 0.56, (0.50, 0.63) to IOR 0.27 (0.25, 0.29)]. Conclusions: Rising rates of T2D associated complications in younger adults signal an emerging epidemic of early-onset comorbidity with substantial lifetime burden. These findings emphasise the urgent need for earlier detection, aggressive risk factor management, and targeted prevention strategies in younger populations.
AB - Aims: To characterise recent trends in incidence and prevalence of type 2 diabetes (T2D) associated complications, and their relative impact across the lifespan. Methods: We conducted a retrospective cohort study using the TriNetX global federated database. Incidence and prevalence of T2D and associated complications: ischaemic heart disease (IHD), heart failure, cerebral infarction, neuropathy, nephropathy, and retinopathy were assessed between 2012 and 2023. Incidence odds ratios (IOR) were calculated by age group. Results: 7,918,666 individuals had T2D. The IOR (95 % CI), comparing individuals aged ≥ 85 years to < 35 years decreased for all complications from 2012 to 2023: IHD [IOR 6.82, (6.40, 7.26) to IOR 2.27 (2.17, 2.38)], heart failure [IOR 5.38, (5.03, 5.75) to IOR 1.80 (1.72, 1.89)], cerebral infarction [IOR 3.06, (2.76, 3.40) to IOR 1.45 (1.34, 1.57)], neuropathy [IOR 0.84, (0.74, 0.95) to IOR 0.47 (0.44, 0.49)], nephropathy [IOR 1.14, (1.03, 1.27) to IOR 0.90 (0.87, 0.94)] and retinopathy [IOR 0.56, (0.50, 0.63) to IOR 0.27 (0.25, 0.29)]. Conclusions: Rising rates of T2D associated complications in younger adults signal an emerging epidemic of early-onset comorbidity with substantial lifetime burden. These findings emphasise the urgent need for earlier detection, aggressive risk factor management, and targeted prevention strategies in younger populations.
KW - Epidemiology
KW - Macrovascular
KW - Microvascular
KW - Type 2 diabetes
U2 - 10.1016/j.diabres.2025.112431
DO - 10.1016/j.diabres.2025.112431
M3 - Article
C2 - 40858214
AN - SCOPUS:105014029574
SN - 0168-8227
VL - 228
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 112431
ER -
