TY - JOUR
T1 - The overlapping burden of the three leading causes of disability and death in sub-Saharan African children
AU - Reiner, Robert C.
AU - Welgan, Catherine A.
AU - Troeger, Christopher E.
AU - Baumann, Mathew M.
AU - Weiss, Daniel J.
AU - Deshpande, Aniruddha
AU - Blacker, Brigette F.
AU - Miller-Petrie, Molly K.
AU - Earl, Lucas
AU - Bhatt, Samir
AU - Abolhassani, Hassan
AU - Abosetugn, Akine Eshete
AU - Abu-Gharbieh, Eman
AU - Adekanmbi, Victor
AU - Adetokunboh, Olatunji O.
AU - Aghaali, Mohammad
AU - Aji, Budi
AU - Alahdab, Fares
AU - Al-Aly, Ziyad
AU - Alhassan, Robert Kaba
AU - Ali, Saqib
AU - Alizade, Hesam
AU - Aljunid, Syed Mohamed
AU - Almasi-Hashiani, Amir
AU - Al-Mekhlafi, Hesham M.
AU - Altirkawi, Khalid A.
AU - Alvis-Guzman, Nelson
AU - Amare, Azmeraw T.
AU - Amini, Saeed
AU - Amugsi, Dickson A.
AU - Ancuceanu, Robert
AU - Andrei, Catalina Liliana
AU - Ansari, Fereshteh
AU - Anvari, Davood
AU - Appiah, Seth Christopher Yaw
AU - Arabloo, Jalal
AU - Aremu, Olatunde
AU - Atout, Maha Moh’d Wahbi
AU - Ausloos, Marcel
AU - Ausloos, Floriane
AU - Ayanore, Martin Amogre
AU - Aynalem, Yared Asmare
AU - Azene, Zelalem Nigussie
AU - Badawi, Alaa
AU - Baig, Atif Amin
AU - Banach, Maciej
AU - Bedi, Neeraj
AU - Bhagavathula, Akshaya Srikanth
AU - Bhandari, Dinesh
AU - Longbottom, Joshua
PY - 2022/12/6
Y1 - 2022/12/6
N2 - Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.
AB - Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.
U2 - 10.1038/s41467-022-34240-6
DO - 10.1038/s41467-022-34240-6
M3 - Article
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 7457
ER -
SDG 3 Good Health and Well-being