TY - JOUR
T1 - The interactions between maternal iron supplementation and iron metabolism-related genetic polymorphisms on birth outcomes: a prospective study in Chinese
AU - Liu, Danmeng
AU - Cheng, Yue
AU - Qu, Pengfei
AU - Zhao, Doudou
AU - Li, Shanshan
AU - Zeng, Lingxia
AU - Zhu, Zhonghai
AU - Qi, Qi
AU - Mi, Baibing
AU - Zhang, Binyan
AU - Jing, Hui
AU - Yan, Hong
AU - Wang, Duolao
AU - Dang, Shaonong
PY - 2023/6/28
Y1 - 2023/6/28
N2 - BACKGROUNDThe effect of iron supplementation during pregnancy on birth outcomes may vary with maternal genetic background and needs more investigation.OBJECTIVEThis prospective study aimed to evaluate the interactions between maternal iron supplementation and iron metabolism-related genetic polymorphisms on birth outcomes.METHODSThis was a sub-study from a cluster-randomized control trial conducted in Northwest China, which included 860 women from the two micronutrient supplementation groups (folic acid (FA) and FA + iron group). Maternal peripheral blood, socio-demographic and health-related information, and neonatal birth outcomes were collected. Six single nucleotide polymorphisms (SNPs) in iron metabolism-related genes were genotyped. The alleles associated with decreased iron/hemoglobin status were used as the effect alleles. The genetic risk score (GRS) that reflected the genetic risk of low iron/hemoglobin status was estimated using the unweighted and weighted methods. Generalized estimating equation with small-sample corrections were applied to evaluate the interactions between iron supplementation and SNPs/GRS on birth outcomes.RESULTSThere were significant interactions between maternal iron supplementation and rs7385804 (P=0.009), rs149411 (P=0.035), rs4820268 (P=0.031), the unweighted GRS (P=0.018), and the weighted GRS (P=0.009) on birth weight. Compared with FA supplementation only, FA + iron supplementation significantly increased birth weight among women with more effect alleles in rs7385804 (β: 88.8 g, 95% CI: 9.2, 168.3) and the GRSs (the highest unweighted GRS: β 135.5 g, 95% CI: 7.7, 263.4; the highest weighted GRS: β 145.9 g, 95% CI: 43.4, 248.5); it had a trend of decreasing birth weight and increasing low birth weight risk among women with fewer effect alleles. results CONCLUSION: In our population, maternal genetic background related to iron metabolism plays a significant role in determining the efficacy of iron supplementation. Routine iron supplementation could be more beneficial to fetal weight growth among mothers with higher genetic risk for low iron/hemoglobin status.
AB - BACKGROUNDThe effect of iron supplementation during pregnancy on birth outcomes may vary with maternal genetic background and needs more investigation.OBJECTIVEThis prospective study aimed to evaluate the interactions between maternal iron supplementation and iron metabolism-related genetic polymorphisms on birth outcomes.METHODSThis was a sub-study from a cluster-randomized control trial conducted in Northwest China, which included 860 women from the two micronutrient supplementation groups (folic acid (FA) and FA + iron group). Maternal peripheral blood, socio-demographic and health-related information, and neonatal birth outcomes were collected. Six single nucleotide polymorphisms (SNPs) in iron metabolism-related genes were genotyped. The alleles associated with decreased iron/hemoglobin status were used as the effect alleles. The genetic risk score (GRS) that reflected the genetic risk of low iron/hemoglobin status was estimated using the unweighted and weighted methods. Generalized estimating equation with small-sample corrections were applied to evaluate the interactions between iron supplementation and SNPs/GRS on birth outcomes.RESULTSThere were significant interactions between maternal iron supplementation and rs7385804 (P=0.009), rs149411 (P=0.035), rs4820268 (P=0.031), the unweighted GRS (P=0.018), and the weighted GRS (P=0.009) on birth weight. Compared with FA supplementation only, FA + iron supplementation significantly increased birth weight among women with more effect alleles in rs7385804 (β: 88.8 g, 95% CI: 9.2, 168.3) and the GRSs (the highest unweighted GRS: β 135.5 g, 95% CI: 7.7, 263.4; the highest weighted GRS: β 145.9 g, 95% CI: 43.4, 248.5); it had a trend of decreasing birth weight and increasing low birth weight risk among women with fewer effect alleles. results CONCLUSION: In our population, maternal genetic background related to iron metabolism plays a significant role in determining the efficacy of iron supplementation. Routine iron supplementation could be more beneficial to fetal weight growth among mothers with higher genetic risk for low iron/hemoglobin status.
KW - birth outcomes
KW - gene-nutrient interaction
KW - genetic risk score
KW - iron supplementation
KW - pregnancy
KW - single nucleotide polymorphisms
U2 - 10.1016/j.tjnut.2023.06.036
DO - 10.1016/j.tjnut.2023.06.036
M3 - Article
SN - 0022-3166
VL - 153
SP - 2442
EP - 2452
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 8
ER -