TY - JOUR
T1 - The impact of stopping and starting indoor residual spraying on malaria burden in Uganda
AU - Namuganga, Jane Frances
AU - Epstein, Adrienne
AU - Nankabirwa, Joaniter I.
AU - Mpimbaza, Arthur
AU - Kiggundu, Moses
AU - Sserwanga, Asadu
AU - Kapisi, James
AU - Arinaitwe, Emmanuel
AU - Gonahasa, Samuel
AU - Opigo, Jimmy
AU - Ebong, Chris
AU - Staedke, Sarah
AU - Shililu, Josephat
AU - Okia, Michael
AU - Rutazaana, Damian
AU - Maiteki-Sebuguzi, Catherine
AU - Belay, Kassahun
AU - Kamya, Moses R.
AU - Dorsey, Grant
AU - Rodriguez-Barraquer, Isabel
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The scale-up of malaria control efforts has led to marked reductions in malaria burden over the past twenty years, but progress has slowed. Implementation of indoor residual spraying (IRS) of insecticide, a proven vector control intervention, has been limited and difficult to sustain partly because questions remain on its added impact over widely accepted interventions such as bed nets. Using data from 14 enhanced surveillance health facilities in Uganda, a country with high bed net coverage yet high malaria burden, we estimate the impact of starting and stopping IRS on changes in malaria incidence. We show that stopping IRS was associated with a 5-fold increase in malaria incidence within 10 months, but reinstating IRS was associated with an over 5-fold decrease within 8 months. In areas where IRS was initiated and sustained, malaria incidence dropped by 85% after year 4. IRS could play a critical role in achieving global malaria targets, particularly in areas where progress has stalled.
AB - The scale-up of malaria control efforts has led to marked reductions in malaria burden over the past twenty years, but progress has slowed. Implementation of indoor residual spraying (IRS) of insecticide, a proven vector control intervention, has been limited and difficult to sustain partly because questions remain on its added impact over widely accepted interventions such as bed nets. Using data from 14 enhanced surveillance health facilities in Uganda, a country with high bed net coverage yet high malaria burden, we estimate the impact of starting and stopping IRS on changes in malaria incidence. We show that stopping IRS was associated with a 5-fold increase in malaria incidence within 10 months, but reinstating IRS was associated with an over 5-fold decrease within 8 months. In areas where IRS was initiated and sustained, malaria incidence dropped by 85% after year 4. IRS could play a critical role in achieving global malaria targets, particularly in areas where progress has stalled.
U2 - 10.1038/s41467-021-22896-5
DO - 10.1038/s41467-021-22896-5
M3 - Article
SN - 2041-1723
VL - 12
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 2635
ER -
