The Impact of Horizontal Gene Transfer on the Biology of Clostridium difficile

Adam Roberts; Elaine Allan; Peter Mullany

doi:10.1016/bs.ampbs.2014.08.002

The Impact of Horizontal Gene Transfer on the Biology of Clostridium difficile

Adam Roberts, Elaine Allan, Peter Mullany

University College London

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

16 Citations (Scopus)

Abstract

Clostridium difficile infection (CDI) is now recognised as the main cause of healthcare associated diarrhoea. Over the recent years there has been a change in the epidemiology of CDI with certain related strains dominating infection. These strains have been termed hyper-virulent and have successfully spread across the globe. Many C. difficile strains have had their genomes completely sequenced allowing researchers to build up a very detailed picture of the contribution of horizontal gene transfer to the adaptive potential, through the acquisition of mobile DNA, of this organism. Here, we review and discuss the contribution of mobile genetic elements to the biology of this clinically important pathogen.

Original language	English
Title of host publication	Advances in Microbial Physiology
Pages	63-82
Number of pages	20
DOIs	https://doi.org/10.1016/bs.ampbs.2014.08.002
Publication status	Published - 1 Jan 2014
Externally published	Yes

Keywords

Bacteriophage
Clostridium difficile
Conjugative transposon
Horizontal gene transfer
Mobile genetic elements
Mobilisable transposon
PaLoc
Transposon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/bs.ampbs.2014.08.002

Cite this

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title = "The Impact of Horizontal Gene Transfer on the Biology of Clostridium difficile",

abstract = "Clostridium difficile infection (CDI) is now recognised as the main cause of healthcare associated diarrhoea. Over the recent years there has been a change in the epidemiology of CDI with certain related strains dominating infection. These strains have been termed hyper-virulent and have successfully spread across the globe. Many C. difficile strains have had their genomes completely sequenced allowing researchers to build up a very detailed picture of the contribution of horizontal gene transfer to the adaptive potential, through the acquisition of mobile DNA, of this organism. Here, we review and discuss the contribution of mobile genetic elements to the biology of this clinically important pathogen.",

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AU - Allan, Elaine

AU - Mullany, Peter

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N2 - Clostridium difficile infection (CDI) is now recognised as the main cause of healthcare associated diarrhoea. Over the recent years there has been a change in the epidemiology of CDI with certain related strains dominating infection. These strains have been termed hyper-virulent and have successfully spread across the globe. Many C. difficile strains have had their genomes completely sequenced allowing researchers to build up a very detailed picture of the contribution of horizontal gene transfer to the adaptive potential, through the acquisition of mobile DNA, of this organism. Here, we review and discuss the contribution of mobile genetic elements to the biology of this clinically important pathogen.

AB - Clostridium difficile infection (CDI) is now recognised as the main cause of healthcare associated diarrhoea. Over the recent years there has been a change in the epidemiology of CDI with certain related strains dominating infection. These strains have been termed hyper-virulent and have successfully spread across the globe. Many C. difficile strains have had their genomes completely sequenced allowing researchers to build up a very detailed picture of the contribution of horizontal gene transfer to the adaptive potential, through the acquisition of mobile DNA, of this organism. Here, we review and discuss the contribution of mobile genetic elements to the biology of this clinically important pathogen.

KW - Bacteriophage

KW - Clostridium difficile

KW - Conjugative transposon

KW - Horizontal gene transfer

KW - Mobile genetic elements

KW - Mobilisable transposon

KW - PaLoc

KW - Transposon

U2 - 10.1016/bs.ampbs.2014.08.002

DO - 10.1016/bs.ampbs.2014.08.002

M3 - Chapter

SP - 63

EP - 82

BT - Advances in Microbial Physiology

ER -

The Impact of Horizontal Gene Transfer on the Biology of Clostridium difficile

Abstract

Keywords

UN SDGs

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