The GenoType® MTBDRsltest for resistance to second-line anti-tuberculosis drugs (Protocol)

Grant Theron; Jonny Peter; Marinus Barnard; Sarah Donegan; Rob Warren; Karen Steingart; Keertan Dheda; Grant Theron

doi:10.1002/14651858.cd010705

The GenoType® MTBDRsltest for resistance to second-line anti-tuberculosis drugs (Protocol)

Grant Theron, Jonny Peter, Marinus Barnard, Sarah Donegan, Rob Warren, Karen Steingart, Keertan Dheda, Grant Theron

Clinical Sciences

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of resistance to the fluoroquinolones in patient specimens or culture isolates confirmed as TB positive.

To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of resistance to second-line injectable drugs in patient specimens or culture isolates confirmed as TB positive.

To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of XDR-TB in patient specimens or culture isolates confirmed as TB positive.

Purpose of index test: GenoType® MTBDRsl used as an initial test replacing phenotypic culture-based DST as the initial test.

We plan to investigate heterogeneity in relation to the reference tests (genetic sequencing, culture-based DST, and culture-based DST followed by genetic sequencing), as well as by type of testing (indirect or direct). We also plan to investigate heterogeneity in relation to HIV status, conditions of the specimens (fresh or frozen, volume of specimen) and patient population (patients suspected of having MDR-TB or XDR-TB).

Original language	English
Article number	CD010705
Pages (from-to)	CD010705
Journal	Cochrane Database of Systematic Reviews
Volume	2013
Issue number	8
DOIs	https://doi.org/10.1002/14651858.cd010705
Publication status	Published - 1 Aug 2013

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title = "The GenoType{\textregistered} MTBDRsltest for resistance to second-line anti-tuberculosis drugs (Protocol)",

abstract = "This is the protocol for a review and there is no abstract. The objectives are as follows:To obtain summary estimates of the diagnostic accuracy of GenoType{\textregistered} MTBDRsl for detection of resistance to the fluoroquinolones in patient specimens or culture isolates confirmed as TB positive.To obtain summary estimates of the diagnostic accuracy of GenoType{\textregistered} MTBDRsl for detection of resistance to second-line injectable drugs in patient specimens or culture isolates confirmed as TB positive.To obtain summary estimates of the diagnostic accuracy of GenoType{\textregistered} MTBDRsl for detection of XDR-TB in patient specimens or culture isolates confirmed as TB positive.Purpose of index test: GenoType{\textregistered} MTBDRsl used as an initial test replacing phenotypic culture-based DST as the initial test.We plan to investigate heterogeneity in relation to the reference tests (genetic sequencing, culture-based DST, and culture-based DST followed by genetic sequencing), as well as by type of testing (indirect or direct). We also plan to investigate heterogeneity in relation to HIV status, conditions of the specimens (fresh or frozen, volume of specimen) and patient population (patients suspected of having MDR-TB or XDR-TB).",

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AU - Peter, Jonny

AU - Barnard, Marinus

AU - Donegan, Sarah

AU - Warren, Rob

AU - Steingart, Karen

AU - Dheda, Keertan

AU - Theron, Grant

PY - 2013/8/1

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N2 - This is the protocol for a review and there is no abstract. The objectives are as follows:To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of resistance to the fluoroquinolones in patient specimens or culture isolates confirmed as TB positive.To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of resistance to second-line injectable drugs in patient specimens or culture isolates confirmed as TB positive.To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of XDR-TB in patient specimens or culture isolates confirmed as TB positive.Purpose of index test: GenoType® MTBDRsl used as an initial test replacing phenotypic culture-based DST as the initial test.We plan to investigate heterogeneity in relation to the reference tests (genetic sequencing, culture-based DST, and culture-based DST followed by genetic sequencing), as well as by type of testing (indirect or direct). We also plan to investigate heterogeneity in relation to HIV status, conditions of the specimens (fresh or frozen, volume of specimen) and patient population (patients suspected of having MDR-TB or XDR-TB).

AB - This is the protocol for a review and there is no abstract. The objectives are as follows:To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of resistance to the fluoroquinolones in patient specimens or culture isolates confirmed as TB positive.To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of resistance to second-line injectable drugs in patient specimens or culture isolates confirmed as TB positive.To obtain summary estimates of the diagnostic accuracy of GenoType® MTBDRsl for detection of XDR-TB in patient specimens or culture isolates confirmed as TB positive.Purpose of index test: GenoType® MTBDRsl used as an initial test replacing phenotypic culture-based DST as the initial test.We plan to investigate heterogeneity in relation to the reference tests (genetic sequencing, culture-based DST, and culture-based DST followed by genetic sequencing), as well as by type of testing (indirect or direct). We also plan to investigate heterogeneity in relation to HIV status, conditions of the specimens (fresh or frozen, volume of specimen) and patient population (patients suspected of having MDR-TB or XDR-TB).

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JF - Cochrane Database of Systematic Reviews

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ER -

The GenoType® MTBDRsltest for resistance to second-line anti-tuberculosis drugs (Protocol)

Abstract

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