The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

Jianguo Shi; Richard S. McIntosh; Jaime Adame-Gallegos; Prabhjyot K. Dehal; Marjolein van Egmond; Jan van de Winkel; Simon J. Draper; Emily K. Forbes; Patrick H. Corran; Anthony A. Holder; Jenny M. Woof; Richard Pleass

doi:10.1186/1472-6750-11-77

The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

Jianguo Shi
, Richard S. McIntosh
, Jaime Adame-Gallegos
, Prabhjyot K. Dehal
, Marjolein van Egmond
, Jan van de Winkel
, Simon J. Draper
, Emily K. Forbes
, Patrick H. Corran
, Anthony A. Holder
, Jenny M. Woof
, Richard Pleass

Tropical Disease Biology

University of Nottingham
University of Dundee
VU Medical Centre
Utrecht University
University of Oxford
London School of Hygiene and Tropical Medicine
Medical Research Council

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The lack of protection afforded by MSP1 19-specific IgA against parasite challenge in mice transgenic for human FcαRI suggests that this antibody class does not play a major role in control of infection. However, we cannot exclude the possibility that protective capacity may have been compromised in this model due to rapid clearance and inappropriate bio-distribution of IgA, and differences in FcαRI expression profile between humans and transgenic mice.

Original language	English
Article number	77
Pages (from-to)	77
Journal	BMC Biotechnology
Volume	11
DOIs	https://doi.org/10.1186/1472-6750-11-77
Publication status	Published - 22 Jul 2011

Access to Document

10.1186/1472-6750-11-77Licence: CC BY

Pleass-BMC-2011Final published version, 2.01 MBLicence: CC BY

Cite this

Shi, J., McIntosh, R. S., Adame-Gallegos, J., Dehal, P. K., van Egmond, M., van de Winkel, J., Draper, S. J., Forbes, E. K., Corran, P. H., Holder, A. A., Woof, J. M., & Pleass, R. (2011). The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19). BMC Biotechnology, 11, 77. Article 77. https://doi.org/10.1186/1472-6750-11-77

@article{ab60311f971a4b5f9bc4479206b54928,

title = "The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).",

abstract = "The lack of protection afforded by MSP1 19-specific IgA against parasite challenge in mice transgenic for human FcαRI suggests that this antibody class does not play a major role in control of infection. However, we cannot exclude the possibility that protective capacity may have been compromised in this model due to rapid clearance and inappropriate bio-distribution of IgA, and differences in FcαRI expression profile between humans and transgenic mice.",

author = "Jianguo Shi and McIntosh, \{Richard S.\} and Jaime Adame-Gallegos and Dehal, \{Prabhjyot K.\} and \{van Egmond\}, Marjolein and \{van de Winkel\}, Jan and Draper, \{Simon J.\} and Forbes, \{Emily K.\} and Corran, \{Patrick H.\} and Holder, \{Anthony A.\} and Woof, \{Jenny M.\} and Richard Pleass",

year = "2011",

month = jul,

day = "22",

doi = "10.1186/1472-6750-11-77",

language = "English",

volume = "11",

pages = "77",

journal = "BMC Biotechnology",

issn = "1472-6750",

publisher = "BioMed Central Ltd",

}

Shi, J, McIntosh, RS, Adame-Gallegos, J, Dehal, PK, van Egmond, M, van de Winkel, J, Draper, SJ, Forbes, EK, Corran, PH, Holder, AA, Woof, JM & Pleass, R 2011, 'The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).', BMC Biotechnology, vol. 11, 77, pp. 77. https://doi.org/10.1186/1472-6750-11-77

TY - JOUR

T1 - The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

AU - Shi, Jianguo

AU - McIntosh, Richard S.

AU - Adame-Gallegos, Jaime

AU - Dehal, Prabhjyot K.

AU - van Egmond, Marjolein

AU - van de Winkel, Jan

AU - Draper, Simon J.

AU - Forbes, Emily K.

AU - Corran, Patrick H.

AU - Holder, Anthony A.

AU - Woof, Jenny M.

AU - Pleass, Richard

PY - 2011/7/22

Y1 - 2011/7/22

N2 - The lack of protection afforded by MSP1 19-specific IgA against parasite challenge in mice transgenic for human FcαRI suggests that this antibody class does not play a major role in control of infection. However, we cannot exclude the possibility that protective capacity may have been compromised in this model due to rapid clearance and inappropriate bio-distribution of IgA, and differences in FcαRI expression profile between humans and transgenic mice.

AB - The lack of protection afforded by MSP1 19-specific IgA against parasite challenge in mice transgenic for human FcαRI suggests that this antibody class does not play a major role in control of infection. However, we cannot exclude the possibility that protective capacity may have been compromised in this model due to rapid clearance and inappropriate bio-distribution of IgA, and differences in FcαRI expression profile between humans and transgenic mice.

U2 - 10.1186/1472-6750-11-77

DO - 10.1186/1472-6750-11-77

M3 - Article

SN - 1472-6750

VL - 11

SP - 77

JO - BMC Biotechnology

JF - BMC Biotechnology

M1 - 77

ER -

The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

Abstract

Access to Document

Fingerprint

Cite this