The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

Jianguo Shi; Richard S. McIntosh; Jaime Adame-Gallegos; Prabhjyot K. Dehal; Marjolein van Egmond; Jan van de Winkel; Simon J. Draper; Emily K. Forbes; Patrick H. Corran; Anthony A. Holder; Jenny M. Woof; Richard Pleass

doi:10.1186/1472-6750-11-77

The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

Jianguo Shi, Richard S. McIntosh, Jaime Adame-Gallegos, Prabhjyot K. Dehal, Marjolein van Egmond, Jan van de Winkel, Simon J. Draper, Emily K. Forbes, Patrick H. Corran, Anthony A. Holder, Jenny M. Woof, Richard Pleass

Tropical Disease Biology

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20 Citations (Scopus)

Abstract

The lack of protection afforded by MSP1 19-specific IgA against parasite challenge in mice transgenic for human FcαRI suggests that this antibody class does not play a major role in control of infection. However, we cannot exclude the possibility that protective capacity may have been compromised in this model due to rapid clearance and inappropriate bio-distribution of IgA, and differences in FcαRI expression profile between humans and transgenic mice.

Original language	English
Article number	77
Pages (from-to)	77
Journal	BMC Biotechnology
Volume	11
DOIs	https://doi.org/10.1186/1472-6750-11-77
Publication status	Published - 22 Jul 2011

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Shi, J., McIntosh, R. S., Adame-Gallegos, J., Dehal, P. K., van Egmond, M., van de Winkel, J., Draper, S. J., Forbes, E. K., Corran, P. H., Holder, A. A., Woof, J. M., & Pleass, R. (2011). The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19). BMC Biotechnology, 11, 77. Article 77. https://doi.org/10.1186/1472-6750-11-77

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title = "The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).",

abstract = "The lack of protection afforded by MSP1 19-specific IgA against parasite challenge in mice transgenic for human FcαRI suggests that this antibody class does not play a major role in control of infection. However, we cannot exclude the possibility that protective capacity may have been compromised in this model due to rapid clearance and inappropriate bio-distribution of IgA, and differences in FcαRI expression profile between humans and transgenic mice.",

author = "Jianguo Shi and McIntosh, \{Richard S.\} and Jaime Adame-Gallegos and Dehal, \{Prabhjyot K.\} and \{van Egmond\}, Marjolein and \{van de Winkel\}, Jan and Draper, \{Simon J.\} and Forbes, \{Emily K.\} and Corran, \{Patrick H.\} and Holder, \{Anthony A.\} and Woof, \{Jenny M.\} and Richard Pleass",

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doi = "10.1186/1472-6750-11-77",

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Shi, J, McIntosh, RS, Adame-Gallegos, J, Dehal, PK, van Egmond, M, van de Winkel, J, Draper, SJ, Forbes, EK, Corran, PH, Holder, AA, Woof, JM & Pleass, R 2011, 'The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).', BMC Biotechnology, vol. 11, 77, pp. 77. https://doi.org/10.1186/1472-6750-11-77

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T1 - The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

AU - Shi, Jianguo

AU - McIntosh, Richard S.

AU - Adame-Gallegos, Jaime

AU - Dehal, Prabhjyot K.

AU - van Egmond, Marjolein

AU - van de Winkel, Jan

AU - Draper, Simon J.

AU - Forbes, Emily K.

AU - Corran, Patrick H.

AU - Holder, Anthony A.

AU - Woof, Jenny M.

AU - Pleass, Richard

PY - 2011/7/22

Y1 - 2011/7/22

N2 - The lack of protection afforded by MSP1 19-specific IgA against parasite challenge in mice transgenic for human FcαRI suggests that this antibody class does not play a major role in control of infection. However, we cannot exclude the possibility that protective capacity may have been compromised in this model due to rapid clearance and inappropriate bio-distribution of IgA, and differences in FcαRI expression profile between humans and transgenic mice.

AB - The lack of protection afforded by MSP1 19-specific IgA against parasite challenge in mice transgenic for human FcαRI suggests that this antibody class does not play a major role in control of infection. However, we cannot exclude the possibility that protective capacity may have been compromised in this model due to rapid clearance and inappropriate bio-distribution of IgA, and differences in FcαRI expression profile between humans and transgenic mice.

U2 - 10.1186/1472-6750-11-77

DO - 10.1186/1472-6750-11-77

M3 - Article

SN - 1472-6750

VL - 11

SP - 77

JO - BMC Biotechnology

JF - BMC Biotechnology

M1 - 77

ER -

The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

Abstract

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