The Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya

Richard Omore; Alex O. Awuor; Billy Ogwel; Caleb Okonji; Catherine Sonye; Caren Oreso; Victor Akelo; Manase Amollo; Isaiah Ogudi; Raphael O. Anyango; Marjorie Audi; Evans Apondi; Laura Riziki; Lilian Ambila; Nasrin Dilruba; Erick Muok; Stephen Munga; John B. Ochieng; Karen L. Kotloff

doi:10.1093/ofid/ofad654

The Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya

Richard Omore, Alex O. Awuor, Billy Ogwel, Caleb Okonji, Catherine Sonye, Caren Oreso, Victor Akelo, Manase Amollo, Isaiah Ogudi, Raphael O. Anyango, Marjorie Audi, Evans Apondi, Laura Riziki, Lilian Ambila, Nasrin Dilruba, Erick Muok, Stephen Munga, John B. Ochieng, Karen L. Kotloff

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: Although Shigella is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based Shigella estimates and eventual Shigella-targeted clinical trials are needed to improve Shigella-related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of Shigella diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future Shigella vaccine trials.

Methods: We mobilized our preexisting expertise in shigellosis, vaccinology, and diarrheal disease epidemiology, which we combined with our experience conducting population-based sampling, clinical trials with high (97%–98%) retention rates, and healthcare utilization surveys. We leveraged our established demographic surveillance system (DSS), our network of healthcare centers serving the DSS, and our laboratory facilities with staff experienced in performing microbiologic and molecular diagnostics to identify enteric infections. We joined these resources with an international network of sites with similar capabilities and infrastructure to form a cohesive scientific network, designated Enterics for Global Health (EFGH), with the aim of expanding and updating our knowledge of the epidemiology and adverse consequences of shigellosis and enriching local research and career development priorities.

Conclusions: Shigella surveillance data from this platform could help inform Shigella vaccine trials.

Original language	English
Pages (from-to)	S91-S100
Journal	Open Forum Infectious Diseases
Volume	11
Issue number	Supplement_1
Early online date	25 Mar 2024
DOIs	https://doi.org/10.1093/ofid/ofad654
Publication status	Published - 25 Mar 2024

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Omore, R., Awuor, A. O., Ogwel, B., Okonji, C., Sonye, C., Oreso, C., Akelo, V., Amollo, M., Ogudi, I., Anyango, R. O., Audi, M., Apondi, E., Riziki, L., Ambila, L., Dilruba, N., Muok, E., Munga, S., Ochieng, J. B., & Kotloff, K. L. (2024). The Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya. Open Forum Infectious Diseases, 11(Supplement_1), S91-S100. https://doi.org/10.1093/ofid/ofad654

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title = "The Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya",

abstract = "Background: Although Shigella is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based Shigella estimates and eventual Shigella-targeted clinical trials are needed to improve Shigella-related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of Shigella diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future Shigella vaccine trials. Methods: We mobilized our preexisting expertise in shigellosis, vaccinology, and diarrheal disease epidemiology, which we combined with our experience conducting population-based sampling, clinical trials with high (97\%–98\%) retention rates, and healthcare utilization surveys. We leveraged our established demographic surveillance system (DSS), our network of healthcare centers serving the DSS, and our laboratory facilities with staff experienced in performing microbiologic and molecular diagnostics to identify enteric infections. We joined these resources with an international network of sites with similar capabilities and infrastructure to form a cohesive scientific network, designated Enterics for Global Health (EFGH), with the aim of expanding and updating our knowledge of the epidemiology and adverse consequences of shigellosis and enriching local research and career development priorities. Conclusions: Shigella surveillance data from this platform could help inform Shigella vaccine trials.",

author = "Richard Omore and Awuor, \{Alex O.\} and Billy Ogwel and Caleb Okonji and Catherine Sonye and Caren Oreso and Victor Akelo and Manase Amollo and Isaiah Ogudi and Anyango, \{Raphael O.\} and Marjorie Audi and Evans Apondi and Laura Riziki and Lilian Ambila and Nasrin Dilruba and Erick Muok and Stephen Munga and Ochieng, \{John B.\} and Kotloff, \{Karen L.\}",

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month = mar,

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doi = "10.1093/ofid/ofad654",

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Omore, R, Awuor, AO, Ogwel, B, Okonji, C, Sonye, C, Oreso, C, Akelo, V, Amollo, M, Ogudi, I, Anyango, RO, Audi, M, Apondi, E, Riziki, L, Ambila, L, Dilruba, N, Muok, E, Munga, S, Ochieng, JB & Kotloff, KL 2024, 'The Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya', Open Forum Infectious Diseases, vol. 11, no. Supplement_1, pp. S91-S100. https://doi.org/10.1093/ofid/ofad654

TY - JOUR

T1 - The Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya

AU - Omore, Richard

AU - Awuor, Alex O.

AU - Ogwel, Billy

AU - Okonji, Caleb

AU - Sonye, Catherine

AU - Oreso, Caren

AU - Akelo, Victor

AU - Amollo, Manase

AU - Ogudi, Isaiah

AU - Anyango, Raphael O.

AU - Audi, Marjorie

AU - Apondi, Evans

AU - Riziki, Laura

AU - Ambila, Lilian

AU - Dilruba, Nasrin

AU - Muok, Erick

AU - Munga, Stephen

AU - Ochieng, John B.

AU - Kotloff, Karen L.

PY - 2024/3/25

Y1 - 2024/3/25

N2 - Background: Although Shigella is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based Shigella estimates and eventual Shigella-targeted clinical trials are needed to improve Shigella-related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of Shigella diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future Shigella vaccine trials. Methods: We mobilized our preexisting expertise in shigellosis, vaccinology, and diarrheal disease epidemiology, which we combined with our experience conducting population-based sampling, clinical trials with high (97%–98%) retention rates, and healthcare utilization surveys. We leveraged our established demographic surveillance system (DSS), our network of healthcare centers serving the DSS, and our laboratory facilities with staff experienced in performing microbiologic and molecular diagnostics to identify enteric infections. We joined these resources with an international network of sites with similar capabilities and infrastructure to form a cohesive scientific network, designated Enterics for Global Health (EFGH), with the aim of expanding and updating our knowledge of the epidemiology and adverse consequences of shigellosis and enriching local research and career development priorities. Conclusions: Shigella surveillance data from this platform could help inform Shigella vaccine trials.

AB - Background: Although Shigella is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based Shigella estimates and eventual Shigella-targeted clinical trials are needed to improve Shigella-related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of Shigella diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future Shigella vaccine trials. Methods: We mobilized our preexisting expertise in shigellosis, vaccinology, and diarrheal disease epidemiology, which we combined with our experience conducting population-based sampling, clinical trials with high (97%–98%) retention rates, and healthcare utilization surveys. We leveraged our established demographic surveillance system (DSS), our network of healthcare centers serving the DSS, and our laboratory facilities with staff experienced in performing microbiologic and molecular diagnostics to identify enteric infections. We joined these resources with an international network of sites with similar capabilities and infrastructure to form a cohesive scientific network, designated Enterics for Global Health (EFGH), with the aim of expanding and updating our knowledge of the epidemiology and adverse consequences of shigellosis and enriching local research and career development priorities. Conclusions: Shigella surveillance data from this platform could help inform Shigella vaccine trials.

U2 - 10.1093/ofid/ofad654

DO - 10.1093/ofid/ofad654

M3 - Article

SN - 2328-8957

VL - 11

SP - S91-S100

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - Supplement_1

ER -

The Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya

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