The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods

Penelope Phillips-Howard; Feiko Ter Kuile; Bernard L. Nahlen; Jane A. Alaii; John E. Gimnig; Margarette S. Kolczak; Anja Terlouw; Simon Kariuki; Ya Ping Shi; S. Patrick Kachur; Allen W. Hightower; John M. Vulule; William A. Hawley

doi:10.4269/ajtmh.2003.68.10

The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods

Penelope Phillips-Howard, Feiko Ter Kuile, Bernard L. Nahlen, Jane A. Alaii, John E. Gimnig, Margarette S. Kolczak, Anja Terlouw, Simon Kariuki, Ya Ping Shi, S. Patrick Kachur, Allen W. Hightower, John M. Vulule, William A. Hawley

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

This paper describes the study design and methods used in a large community-based, group-randomized, controlled trial of permethrin-treated bed nets (ITNs) in an area with intense, perennial malaria transmission in western Kenya conducted between 1996 and 1999. A multi-disciplinary framework was used to explore the efficacy of ITNs in the reduction of all-cause mortality in children less than five years old, the clinical, entomologic, immunologic, and economic impact of ITNs, the social and behavioral determinants of ITN use, and the use of a geographic information system to allow for spatial analyses of these outcomes. Methodologic difficulties encountered in such large-scale field trials are discussed.

Original language	English
Pages (from-to)	10-15
Number of pages	6
Journal	The American Journal of Tropical Medicine and Hygiene
Volume	68
Issue number	4 SUPPL.
DOIs	https://doi.org/10.4269/ajtmh.2003.68.10
Publication status	Published - 1 Apr 2003
Externally published	Yes

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Phillips-Howard, P., Ter Kuile, F., Nahlen, B. L., Alaii, J. A., Gimnig, J. E., Kolczak, M. S., Terlouw, A., Kariuki, S., Shi, Y. P., Kachur, S. P., Hightower, A. W., Vulule, J. M., & Hawley, W. A. (2003). The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods. The American Journal of Tropical Medicine and Hygiene, 68(4 SUPPL.), 10-15. https://doi.org/10.4269/ajtmh.2003.68.10

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title = "The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods",

abstract = "This paper describes the study design and methods used in a large community-based, group-randomized, controlled trial of permethrin-treated bed nets (ITNs) in an area with intense, perennial malaria transmission in western Kenya conducted between 1996 and 1999. A multi-disciplinary framework was used to explore the efficacy of ITNs in the reduction of all-cause mortality in children less than five years old, the clinical, entomologic, immunologic, and economic impact of ITNs, the social and behavioral determinants of ITN use, and the use of a geographic information system to allow for spatial analyses of these outcomes. Methodologic difficulties encountered in such large-scale field trials are discussed.",

author = "Penelope Phillips-Howard and \{Ter Kuile\}, Feiko and Nahlen, \{Bernard L.\} and Alaii, \{Jane A.\} and Gimnig, \{John E.\} and Kolczak, \{Margarette S.\} and Anja Terlouw and Simon Kariuki and Shi, \{Ya Ping\} and Kachur, \{S. Patrick\} and Hightower, \{Allen W.\} and Vulule, \{John M.\} and Hawley, \{William A.\}",

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doi = "10.4269/ajtmh.2003.68.10",

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Phillips-Howard, P , Ter Kuile, F, Nahlen, BL, Alaii, JA, Gimnig, JE, Kolczak, MS, Terlouw, A, Kariuki, S, Shi, YP, Kachur, SP, Hightower, AW, Vulule, JM & Hawley, WA 2003, 'The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods', The American Journal of Tropical Medicine and Hygiene, vol. 68, no. 4 SUPPL., pp. 10-15. https://doi.org/10.4269/ajtmh.2003.68.10

TY - JOUR

T1 - The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods

AU - Phillips-Howard, Penelope

AU - Ter Kuile, Feiko

AU - Nahlen, Bernard L.

AU - Alaii, Jane A.

AU - Gimnig, John E.

AU - Kolczak, Margarette S.

AU - Terlouw, Anja

AU - Kariuki, Simon

AU - Shi, Ya Ping

AU - Kachur, S. Patrick

AU - Hightower, Allen W.

AU - Vulule, John M.

AU - Hawley, William A.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - This paper describes the study design and methods used in a large community-based, group-randomized, controlled trial of permethrin-treated bed nets (ITNs) in an area with intense, perennial malaria transmission in western Kenya conducted between 1996 and 1999. A multi-disciplinary framework was used to explore the efficacy of ITNs in the reduction of all-cause mortality in children less than five years old, the clinical, entomologic, immunologic, and economic impact of ITNs, the social and behavioral determinants of ITN use, and the use of a geographic information system to allow for spatial analyses of these outcomes. Methodologic difficulties encountered in such large-scale field trials are discussed.

AB - This paper describes the study design and methods used in a large community-based, group-randomized, controlled trial of permethrin-treated bed nets (ITNs) in an area with intense, perennial malaria transmission in western Kenya conducted between 1996 and 1999. A multi-disciplinary framework was used to explore the efficacy of ITNs in the reduction of all-cause mortality in children less than five years old, the clinical, entomologic, immunologic, and economic impact of ITNs, the social and behavioral determinants of ITN use, and the use of a geographic information system to allow for spatial analyses of these outcomes. Methodologic difficulties encountered in such large-scale field trials are discussed.

U2 - 10.4269/ajtmh.2003.68.10

DO - 10.4269/ajtmh.2003.68.10

M3 - Article

VL - 68

SP - 10

EP - 15

JO - The American Journal of Tropical Medicine and Hygiene

JF - The American Journal of Tropical Medicine and Hygiene

IS - 4 SUPPL.

ER -

The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods

Abstract

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