The effect of fluorine substitution on the antimalarial activity of tebuquine

Paul M. O'Neill; Shaun R. Hawley; Richard C. Storr; Steve Ward; B. Kevin Park

doi:10.1016/0960-894x(96)00040-6

The effect of fluorine substitution on the antimalarial activity of tebuquine

Paul M. O'Neill
, Shaun R. Hawley
, Richard C. Storr
, Steve Ward
, B. Kevin Park

University of Liverpool

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A novel synthetic route has been developed for the synthesis of fluorotebuquine which was active against the chloroquine resistant K1 strain of Plasmodium falciparum, but less potent than both chloroquine and tebuquine against the 3D7 strain.

Original language	English
Pages (from-to)	391-392
Number of pages	2
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/0960-894x(96)00040-6
Publication status	Published - 20 Feb 1996
Externally published	Yes

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title = "The effect of fluorine substitution on the antimalarial activity of tebuquine",

abstract = "A novel synthetic route has been developed for the synthesis of fluorotebuquine which was active against the chloroquine resistant K1 strain of Plasmodium falciparum, but less potent than both chloroquine and tebuquine against the 3D7 strain.",

author = "O'Neill, \{Paul M.\} and Hawley, \{Shaun R.\} and Storr, \{Richard C.\} and Steve Ward and Park, \{B. Kevin\}",

year = "1996",

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doi = "10.1016/0960-894x(96)00040-6",

language = "English",

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T1 - The effect of fluorine substitution on the antimalarial activity of tebuquine

AU - O'Neill, Paul M.

AU - Hawley, Shaun R.

AU - Storr, Richard C.

AU - Ward, Steve

AU - Park, B. Kevin

PY - 1996/2/20

Y1 - 1996/2/20

N2 - A novel synthetic route has been developed for the synthesis of fluorotebuquine which was active against the chloroquine resistant K1 strain of Plasmodium falciparum, but less potent than both chloroquine and tebuquine against the 3D7 strain.

AB - A novel synthetic route has been developed for the synthesis of fluorotebuquine which was active against the chloroquine resistant K1 strain of Plasmodium falciparum, but less potent than both chloroquine and tebuquine against the 3D7 strain.

U2 - 10.1016/0960-894x(96)00040-6

DO - 10.1016/0960-894x(96)00040-6

M3 - Article

VL - 6

SP - 391

EP - 392

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 4

ER -

The effect of fluorine substitution on the antimalarial activity of tebuquine

Abstract

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