The cellular antiviral restriction factor tetherin does not inhibit poxviral replication

Katja Sliva; Theresa Resch; Benjamin Kraus; Christine Goffinet; Oliver T. Keppler; Barbara S. Schnierle

doi:10.1128/jvi.05198-11

The cellular antiviral restriction factor tetherin does not inhibit poxviral replication

Katja Sliva
, Theresa Resch
, Benjamin Kraus
, Christine Goffinet
, Oliver T. Keppler
, Barbara S. Schnierle

Paul-Ehrlich-Institut
Heidelberg University

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Interferon-stimulated genes fulfill innate antiviral effector functions. Among them, tetherin (THN) blocks the release of many enveloped viruses from infected cells. Vaccinia virus (VACV) encodes immune modulators interfering with antiviral host responses. Therefore, it was tempting to study a potential VACV-THN interaction. Remarkably, THN expression did not inhibit VACV release and replication. VACV infection did not diminish THN surface levels or impair its function on retroviral release. This suggests that THN is unable to restrict VACV replication.

Original language	English
Pages (from-to)	1893-1896
Number of pages	4
Journal	Journal of Virology
Volume	86
Issue number	3
DOIs	https://doi.org/10.1128/jvi.05198-11
Publication status	Published - 1 Feb 2012
Externally published	Yes

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10.1128/jvi.05198-11

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abstract = "Interferon-stimulated genes fulfill innate antiviral effector functions. Among them, tetherin (THN) blocks the release of many enveloped viruses from infected cells. Vaccinia virus (VACV) encodes immune modulators interfering with antiviral host responses. Therefore, it was tempting to study a potential VACV-THN interaction. Remarkably, THN expression did not inhibit VACV release and replication. VACV infection did not diminish THN surface levels or impair its function on retroviral release. This suggests that THN is unable to restrict VACV replication.",

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AU - Resch, Theresa

AU - Kraus, Benjamin

AU - Goffinet, Christine

AU - Keppler, Oliver T.

AU - Schnierle, Barbara S.

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AB - Interferon-stimulated genes fulfill innate antiviral effector functions. Among them, tetherin (THN) blocks the release of many enveloped viruses from infected cells. Vaccinia virus (VACV) encodes immune modulators interfering with antiviral host responses. Therefore, it was tempting to study a potential VACV-THN interaction. Remarkably, THN expression did not inhibit VACV release and replication. VACV infection did not diminish THN surface levels or impair its function on retroviral release. This suggests that THN is unable to restrict VACV replication.

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DO - 10.1128/jvi.05198-11

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The cellular antiviral restriction factor tetherin does not inhibit poxviral replication

Abstract

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