TY - JOUR
T1 - Systematic review of therapeutic outcomes of multidrug resistant tuberculosis and their predictors in adults receiving integrated treatment of tuberculosis and human immuno-deficiency virus in low- and middle-income countries: a study protocol
AU - Momo Kadia, Benjamin
AU - Aroke, Desmond
AU - Njefi, Kevin Pene
AU - Tochie, Joel Noutakdie
AU - Tianyi Tianyi, Frank
AU - Kadia, Reine Suzanne
AU - Dimala, Christian Akem
PY - 2020/10/6
Y1 - 2020/10/6
N2 - BackgroundPrograms that integrate tuberculosis (TB) and human immunodeficiency virus (HIV) treatment aim to provide efficient treatment services and maximize successful treatment outcomes through the delivery of both TB and HIV treatment by one provider at the same time and location. However, multi-drug resistant tuberculosis (MDR-TB) is more difficult to treat as compared to drug-sensitive TB, and in low- and middle-income countries (LMICs), the potential of programs integrating TB/HIV treatment to sustain favourable MDR-TB treatment outcomes is poorly elucidated. The objective of this review is to perform a systematic collection, critical appraisal and synthesis of existing evidence on therapeutic outcomes of MDR-TB and their predictors among adults receiving integrated treatment for TB/HIV in LMICs.
AB - BackgroundPrograms that integrate tuberculosis (TB) and human immunodeficiency virus (HIV) treatment aim to provide efficient treatment services and maximize successful treatment outcomes through the delivery of both TB and HIV treatment by one provider at the same time and location. However, multi-drug resistant tuberculosis (MDR-TB) is more difficult to treat as compared to drug-sensitive TB, and in low- and middle-income countries (LMICs), the potential of programs integrating TB/HIV treatment to sustain favourable MDR-TB treatment outcomes is poorly elucidated. The objective of this review is to perform a systematic collection, critical appraisal and synthesis of existing evidence on therapeutic outcomes of MDR-TB and their predictors among adults receiving integrated treatment for TB/HIV in LMICs.
KW - HIV
KW - Integrated treatment
KW - Multidrug-resistant tuberculosis
KW - Outcomes
U2 - 10.1186/s13643-020-01493-5
DO - 10.1186/s13643-020-01493-5
M3 - Review article
SN - 2046-4053
VL - 9
SP - e228
JO - Systematic Reviews
JF - Systematic Reviews
IS - 1
M1 - 228
ER -
