Symptoms associated with influenza vaccination and experimental
human pneumococcal colonisation of the nasopharynx

Caz Hales; Simon P. Jochems; Rachel Robinson; Carla Solórzano; Beatriz Carniel; Sherin Pojar; Jesus Reine Gutierrez; Esther German; Elissavet Nikolaou; Elena Mitsi; Angela D. Hyder-Wright; Helen Hill; Hugh Adler; Victoria Connor; Seher Zaidi; Catherine Lowe; Xiaojing Fan; Duolao Wang; Stephen Gordon; Jamie Rylance; Daniela Ferreira

doi:10.1016/j.vaccine.2020.01.070

Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx

Caz Hales
, Simon P. Jochems
, Rachel Robinson
, Carla Solórzano
, Beatriz Carniel
, Sherin Pojar
, Jesus Reine Gutierrez
, Esther German
, Elissavet Nikolaou
, Elena Mitsi
, Angela D. Hyder-Wright
, Helen Hill
, Hugh Adler
, Victoria Connor
, Seher Zaidi
, Catherine Lowe
, Xiaojing Fan
, Duolao Wang
, Stephen Gordon
, Jamie Rylance

Daniela Ferreira

Liverpool University Hospitals NHS Foundation Trust
Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background

Nasopharyngeal colonisation by S. pneumoniae is a prerequisite for invasive pneumococcal infections. Influenza co-infection leads to increased susceptibility to secondary pneumonia and mortality during influenza epidemics. Increased bacterial load and impaired immune responses to pneumococcus caused by influenza play a role in this increased susceptibility. Using an Experimental Human Challenge Model and influenza vaccines, we examined symptoms experienced by healthy adults during nasal co-infection with S. pneumoniae and live attenuated influenza virus.

Methods

Randomised, blinded administration of Live Attenuated Influenza Vaccine (LAIV) or Tetravalent Inactivated Influenza Vaccine (TIV) either preceded bacterial inoculation or followed it, separated by a 3-day interval. The presence and density of S. pneumoniae was determined from nasal washes. Participants completed a symptom questionnaire from the first intervention until 6 days post second intervention.

Results

The timing and type of influ

Original language	English
Pages (from-to)	2298-2306
Number of pages	9
Journal	Vaccine
Volume	38
Issue number	10
Early online date	5 Feb 2020
DOIs	https://doi.org/10.1016/j.vaccine.2020.01.070
Publication status	Published - 28 Feb 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Controlled human infection challenge model
Influenza vaccination
Live attenuated influenza vaccine
Pneumococcal inoculation
Pneumococcus colonisation
Streptococcus pneumoniae
Symptoms

Access to Document

10.1016/j.vaccine.2020.01.070Licence: CC BY

Hales publishedFinal published version, 1.43 MBLicence: CC BY

Cite this

Hales, C., Jochems, S. P., Robinson, R., Solórzano, C., Carniel, B., Pojar, S., Reine Gutierrez, J., German, E., Nikolaou, E., Mitsi, E., Hyder-Wright, A. D., Hill, H., Adler, H., Connor, V., Zaidi, S., Lowe, C., Fan, X., Wang, D., Gordon, S., ... Ferreira, D. (2020). Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx. Vaccine, 38(10), 2298-2306. https://doi.org/10.1016/j.vaccine.2020.01.070

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title = "Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx",

abstract = "BackgroundNasopharyngeal colonisation by S. pneumoniae is a prerequisite for invasive pneumococcal infections. Influenza co-infection leads to increased susceptibility to secondary pneumonia and mortality during influenza epidemics. Increased bacterial load and impaired immune responses to pneumococcus caused by influenza play a role in this increased susceptibility. Using an Experimental Human Challenge Model and influenza vaccines, we examined symptoms experienced by healthy adults during nasal co-infection with S. pneumoniae and live attenuated influenza virus.MethodsRandomised, blinded administration of Live Attenuated Influenza Vaccine (LAIV) or Tetravalent Inactivated Influenza Vaccine (TIV) either preceded bacterial inoculation or followed it, separated by a 3-day interval. The presence and density of S. pneumoniae was determined from nasal washes. Participants completed a symptom questionnaire from the first intervention until 6 days post second intervention.ResultsThe timing and type of influ",

keywords = "Controlled human infection challenge model, Influenza vaccination, Live attenuated influenza vaccine, Pneumococcal inoculation, Pneumococcus colonisation, Streptococcus pneumoniae, Symptoms",

author = "Caz Hales and Jochems, \{Simon P.\} and Rachel Robinson and Carla Sol{\'o}rzano and Beatriz Carniel and Sherin Pojar and \{Reine Gutierrez\}, Jesus and Esther German and Elissavet Nikolaou and Elena Mitsi and Hyder-Wright, \{Angela D.\} and Helen Hill and Hugh Adler and Victoria Connor and Seher Zaidi and Catherine Lowe and Xiaojing Fan and Duolao Wang and Stephen Gordon and Jamie Rylance and Daniela Ferreira",

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doi = "10.1016/j.vaccine.2020.01.070",

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Hales, C, Jochems, SP, Robinson, R, Solórzano, C, Carniel, B, Pojar, S, Reine Gutierrez, J, German, E, Nikolaou, E, Mitsi, E, Hyder-Wright, AD, Hill, H, Adler, H, Connor, V, Zaidi, S, Lowe, C, Fan, X, Wang, D , Gordon, S, Rylance, J & Ferreira, D 2020, 'Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx', Vaccine, vol. 38, no. 10, pp. 2298-2306. https://doi.org/10.1016/j.vaccine.2020.01.070

TY - JOUR

T1 - Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx

AU - Hales, Caz

AU - Jochems, Simon P.

AU - Robinson, Rachel

AU - Solórzano, Carla

AU - Carniel, Beatriz

AU - Pojar, Sherin

AU - Reine Gutierrez, Jesus

AU - German, Esther

AU - Nikolaou, Elissavet

AU - Mitsi, Elena

AU - Hyder-Wright, Angela D.

AU - Hill, Helen

AU - Adler, Hugh

AU - Connor, Victoria

AU - Zaidi, Seher

AU - Lowe, Catherine

AU - Fan, Xiaojing

AU - Wang, Duolao

AU - Gordon, Stephen

AU - Rylance, Jamie

AU - Ferreira, Daniela

PY - 2020/2/28

Y1 - 2020/2/28

N2 - BackgroundNasopharyngeal colonisation by S. pneumoniae is a prerequisite for invasive pneumococcal infections. Influenza co-infection leads to increased susceptibility to secondary pneumonia and mortality during influenza epidemics. Increased bacterial load and impaired immune responses to pneumococcus caused by influenza play a role in this increased susceptibility. Using an Experimental Human Challenge Model and influenza vaccines, we examined symptoms experienced by healthy adults during nasal co-infection with S. pneumoniae and live attenuated influenza virus.MethodsRandomised, blinded administration of Live Attenuated Influenza Vaccine (LAIV) or Tetravalent Inactivated Influenza Vaccine (TIV) either preceded bacterial inoculation or followed it, separated by a 3-day interval. The presence and density of S. pneumoniae was determined from nasal washes. Participants completed a symptom questionnaire from the first intervention until 6 days post second intervention.ResultsThe timing and type of influ

AB - BackgroundNasopharyngeal colonisation by S. pneumoniae is a prerequisite for invasive pneumococcal infections. Influenza co-infection leads to increased susceptibility to secondary pneumonia and mortality during influenza epidemics. Increased bacterial load and impaired immune responses to pneumococcus caused by influenza play a role in this increased susceptibility. Using an Experimental Human Challenge Model and influenza vaccines, we examined symptoms experienced by healthy adults during nasal co-infection with S. pneumoniae and live attenuated influenza virus.MethodsRandomised, blinded administration of Live Attenuated Influenza Vaccine (LAIV) or Tetravalent Inactivated Influenza Vaccine (TIV) either preceded bacterial inoculation or followed it, separated by a 3-day interval. The presence and density of S. pneumoniae was determined from nasal washes. Participants completed a symptom questionnaire from the first intervention until 6 days post second intervention.ResultsThe timing and type of influ

KW - Controlled human infection challenge model

KW - Influenza vaccination

KW - Live attenuated influenza vaccine

KW - Pneumococcal inoculation

KW - Pneumococcus colonisation

KW - Streptococcus pneumoniae

KW - Symptoms

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DO - 10.1016/j.vaccine.2020.01.070

M3 - Article

SN - 0264-410X

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