Symptomatic, biochemical and radiographic recovery in patients with COVID-19

Patrick Mallia; Jamilah Meghji; Brandon Wong; Kartik Kumar; Victoria Pilkington; Shaan Chhabra; Ben Russell; Jian Chen; Karthikan Srikanthan; Mirae Park; Harriet Owles; Felicity Liew; Joana Alcada; Laura Martin; Meg Coleman; Sarah Elkin; Clare Ross; Shweta Agrawal; Thomas Gardiner; Aaron Bell; Alice White; Dominic Hampson; Gauri Vithlani; Kavina Manalan; Solange Bramer; Alejandra Martin Segura; Anushree Kucheria; Prashanthi Ratnakumar; Alexander Sheeka; Lavanya Anandan; Susan Copley; Georgina Russell; Chloe I. Bloom; Onn Min Kon

doi:10.1136/bmjresp-2021-000908

Symptomatic, biochemical and radiographic recovery in patients with COVID-19

Patrick Mallia, Jamilah Meghji, Brandon Wong, Kartik Kumar, Victoria Pilkington, Shaan Chhabra, Ben Russell, Jian Chen, Karthikan Srikanthan, Mirae Park, Harriet Owles, Felicity Liew, Joana Alcada, Laura Martin, Meg Coleman, Sarah Elkin, Clare Ross, Shweta Agrawal, Thomas Gardiner, Aaron BellAlice White, Dominic Hampson, Gauri Vithlani, Kavina Manalan, Solange Bramer, Alejandra Martin Segura, Anushree Kucheria, Prashanthi Ratnakumar, Alexander Sheeka, Lavanya Anandan, Susan Copley, Georgina Russell, Chloe I. Bloom, Onn Min Kon

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Background

The symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.

Methods

Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.

Results

75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR- positive and PCR- negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge.

Conclusions

Patients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow- up of patients with COVID-19.

Original language	English
Article number	e000908
Pages (from-to)	e000908
Journal	BMJ Open Respiratory Research
Volume	8
Issue number	1
DOIs	https://doi.org/10.1136/bmjresp-2021-000908
Publication status	Published - 24 May 2021

Keywords

COVID-19

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Mallia-2021-Symptomatic-biochemical-and-radiogrFinal published version, 331 KBLicence: CC BY-NC

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Mallia, P., Meghji, J., Wong, B., Kumar, K., Pilkington, V., Chhabra, S., Russell, B., Chen, J., Srikanthan, K., Park, M., Owles, H., Liew, F., Alcada, J., Martin, L., Coleman, M., Elkin, S., Ross, C., Agrawal, S., Gardiner, T., ... Kon, O. M. (2021). Symptomatic, biochemical and radiographic recovery in patients with COVID-19. BMJ Open Respiratory Research, 8(1), e000908. Article e000908. https://doi.org/10.1136/bmjresp-2021-000908

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title = "Symptomatic, biochemical and radiographic recovery in patients with COVID-19",

abstract = "BackgroundThe symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.MethodsRetrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.Results75.1\% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4\%. Symptoms and radiographic abnormalities were similar in PCR- positive and PCR- negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5\% of patients had unscheduled healthcare visits in the 30 days post discharge.ConclusionsPatients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow- up of patients with COVID-19.",

keywords = "COVID-19",

author = "Patrick Mallia and Jamilah Meghji and Brandon Wong and Kartik Kumar and Victoria Pilkington and Shaan Chhabra and Ben Russell and Jian Chen and Karthikan Srikanthan and Mirae Park and Harriet Owles and Felicity Liew and Joana Alcada and Laura Martin and Meg Coleman and Sarah Elkin and Clare Ross and Shweta Agrawal and Thomas Gardiner and Aaron Bell and Alice White and Dominic Hampson and Gauri Vithlani and Kavina Manalan and Solange Bramer and \{Martin Segura\}, Alejandra and Anushree Kucheria and Prashanthi Ratnakumar and Alexander Sheeka and Lavanya Anandan and Susan Copley and Georgina Russell and Bloom, \{Chloe I.\} and Kon, \{Onn Min\}",

year = "2021",

month = may,

day = "24",

doi = "10.1136/bmjresp-2021-000908",

language = "English",

volume = "8",

pages = "e000908",

journal = "BMJ Open Respiratory Research",

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Mallia, P, Meghji, J, Wong, B, Kumar, K, Pilkington, V, Chhabra, S, Russell, B, Chen, J, Srikanthan, K, Park, M, Owles, H, Liew, F, Alcada, J, Martin, L, Coleman, M, Elkin, S, Ross, C, Agrawal, S, Gardiner, T, Bell, A, White, A, Hampson, D, Vithlani, G, Manalan, K, Bramer, S, Martin Segura, A, Kucheria, A, Ratnakumar, P, Sheeka, A, Anandan, L, Copley, S, Russell, G, Bloom, CI & Kon, OM 2021, 'Symptomatic, biochemical and radiographic recovery in patients with COVID-19', BMJ Open Respiratory Research, vol. 8, no. 1, e000908, pp. e000908. https://doi.org/10.1136/bmjresp-2021-000908

TY - JOUR

T1 - Symptomatic, biochemical and radiographic recovery in patients with COVID-19

AU - Mallia, Patrick

AU - Meghji, Jamilah

AU - Wong, Brandon

AU - Kumar, Kartik

AU - Pilkington, Victoria

AU - Chhabra, Shaan

AU - Russell, Ben

AU - Chen, Jian

AU - Srikanthan, Karthikan

AU - Park, Mirae

AU - Owles, Harriet

AU - Liew, Felicity

AU - Alcada, Joana

AU - Martin, Laura

AU - Coleman, Meg

AU - Elkin, Sarah

AU - Ross, Clare

AU - Agrawal, Shweta

AU - Gardiner, Thomas

AU - Bell, Aaron

AU - White, Alice

AU - Hampson, Dominic

AU - Vithlani, Gauri

AU - Manalan, Kavina

AU - Bramer, Solange

AU - Martin Segura, Alejandra

AU - Kucheria, Anushree

AU - Ratnakumar, Prashanthi

AU - Sheeka, Alexander

AU - Anandan, Lavanya

AU - Copley, Susan

AU - Russell, Georgina

AU - Bloom, Chloe I.

AU - Kon, Onn Min

PY - 2021/5/24

Y1 - 2021/5/24

N2 - BackgroundThe symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.MethodsRetrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.Results75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR- positive and PCR- negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge.ConclusionsPatients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow- up of patients with COVID-19.

AB - BackgroundThe symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.MethodsRetrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.Results75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR- positive and PCR- negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge.ConclusionsPatients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow- up of patients with COVID-19.

KW - COVID-19

U2 - 10.1136/bmjresp-2021-000908

DO - 10.1136/bmjresp-2021-000908

M3 - Article

SN - 2052-4439

VL - 8

SP - e000908

JO - BMJ Open Respiratory Research

JF - BMJ Open Respiratory Research

IS - 1

M1 - e000908

ER -

Symptomatic, biochemical and radiographic recovery in patients with COVID-19

Abstract

Keywords

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