Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism

Ymkje Stienstra; T. S. van der Werf; E. Oosterom; I. M. Nolte; W. T.A. van der Graaf; S. Etuaful; P. L. Raghunathan; E. A.S. Whitney; E. O. Ampadu; K. Asamoa; E. Y. Klutse; G. J. te Meerman; J. W. Tappero; D. A. Ashford; G. van der Steege

doi:10.1038/sj.gene.6364281

Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism

Ymkje Stienstra
, T. S. van der Werf
, E. Oosterom
, I. M. Nolte
, W. T.A. van der Graaf
, S. Etuaful
, P. L. Raghunathan
, E. A.S. Whitney
, E. O. Ampadu
, K. Asamoa
, E. Y. Klutse
, G. J. te Meerman
, J. W. Tappero
, D. A. Ashford
, G. van der Steege

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Similar to other mycobacterial diseases, susceptibility to Buruli ulcer (Mycobacterium ulcerans infection) may be determined by host genetic factors. We investigated the role of SLC11A1 (NRAMP1) in Buruli ulcer because of its associations with both tuberculosis and leprosy. We enrolled 182 Buruli ulcer patients (102 with positive laboratory confirmation) and 191 healthy neighbourhood-matched controls in Ghana, and studied three polymorphisms in the SLC11A1 gene: 3′ UTR TGTG ins/del, D543N G/A, and INT4 G/C. Finger prick blood samples from study subjects were dried on filter papers (FTA) and processed. D543N was significantly associated with Buruli ulcer: the odds ratio (adjusted for gender, age, and region of the participant) of the GA genotype versus the GG genotype was 2.89 (95% confidence intervals (CI): 1.41-5.91). We conclude that a genetic polymorphism in the SLC11A1 gene plays a role in susceptibility to develop Buruli ulcer, with an estimated 13% population attributable risk.

Original language	English
Pages (from-to)	185-189
Number of pages	5
Journal	Genes and Immunity
Volume	7
Issue number	3
DOIs	https://doi.org/10.1038/sj.gene.6364281
Publication status	Published - 1 Apr 2006
Externally published	Yes

Keywords

Buruli ulcer
Genetic susceptibility
NRAMP1
SLC11A1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.gene.6364281

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Stienstra, Y., van der Werf, T. S., Oosterom, E., Nolte, I. M., van der Graaf, W. T. A., Etuaful, S., Raghunathan, P. L., Whitney, E. A. S., Ampadu, E. O., Asamoa, K., Klutse, E. Y., te Meerman, G. J., Tappero, J. W., Ashford, D. A., & van der Steege, G. (2006). Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism. Genes and Immunity, 7(3), 185-189. https://doi.org/10.1038/sj.gene.6364281

@article{521ef396ddb24435b4f2e00388c0606d,

title = "Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism",

abstract = "Similar to other mycobacterial diseases, susceptibility to Buruli ulcer (Mycobacterium ulcerans infection) may be determined by host genetic factors. We investigated the role of SLC11A1 (NRAMP1) in Buruli ulcer because of its associations with both tuberculosis and leprosy. We enrolled 182 Buruli ulcer patients (102 with positive laboratory confirmation) and 191 healthy neighbourhood-matched controls in Ghana, and studied three polymorphisms in the SLC11A1 gene: 3′ UTR TGTG ins/del, D543N G/A, and INT4 G/C. Finger prick blood samples from study subjects were dried on filter papers (FTA) and processed. D543N was significantly associated with Buruli ulcer: the odds ratio (adjusted for gender, age, and region of the participant) of the GA genotype versus the GG genotype was 2.89 (95\% confidence intervals (CI): 1.41-5.91). We conclude that a genetic polymorphism in the SLC11A1 gene plays a role in susceptibility to develop Buruli ulcer, with an estimated 13\% population attributable risk.",

keywords = "Buruli ulcer, Genetic susceptibility, NRAMP1, SLC11A1",

author = "Ymkje Stienstra and \{van der Werf\}, \{T. S.\} and E. Oosterom and Nolte, \{I. M.\} and \{van der Graaf\}, \{W. T.A.\} and S. Etuaful and Raghunathan, \{P. L.\} and Whitney, \{E. A.S.\} and Ampadu, \{E. O.\} and K. Asamoa and Klutse, \{E. Y.\} and \{te Meerman\}, \{G. J.\} and Tappero, \{J. W.\} and Ashford, \{D. A.\} and \{van der Steege\}, G.",

year = "2006",

month = apr,

day = "1",

doi = "10.1038/sj.gene.6364281",

language = "English",

volume = "7",

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journal = "Genes and Immunity",

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Stienstra, Y, van der Werf, TS, Oosterom, E, Nolte, IM, van der Graaf, WTA, Etuaful, S, Raghunathan, PL, Whitney, EAS, Ampadu, EO, Asamoa, K, Klutse, EY, te Meerman, GJ, Tappero, JW, Ashford, DA & van der Steege, G 2006, 'Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism', Genes and Immunity, vol. 7, no. 3, pp. 185-189. https://doi.org/10.1038/sj.gene.6364281

TY - JOUR

T1 - Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism

AU - Stienstra, Ymkje

AU - van der Werf, T. S.

AU - Oosterom, E.

AU - Nolte, I. M.

AU - van der Graaf, W. T.A.

AU - Etuaful, S.

AU - Raghunathan, P. L.

AU - Whitney, E. A.S.

AU - Ampadu, E. O.

AU - Asamoa, K.

AU - Klutse, E. Y.

AU - te Meerman, G. J.

AU - Tappero, J. W.

AU - Ashford, D. A.

AU - van der Steege, G.

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Similar to other mycobacterial diseases, susceptibility to Buruli ulcer (Mycobacterium ulcerans infection) may be determined by host genetic factors. We investigated the role of SLC11A1 (NRAMP1) in Buruli ulcer because of its associations with both tuberculosis and leprosy. We enrolled 182 Buruli ulcer patients (102 with positive laboratory confirmation) and 191 healthy neighbourhood-matched controls in Ghana, and studied three polymorphisms in the SLC11A1 gene: 3′ UTR TGTG ins/del, D543N G/A, and INT4 G/C. Finger prick blood samples from study subjects were dried on filter papers (FTA) and processed. D543N was significantly associated with Buruli ulcer: the odds ratio (adjusted for gender, age, and region of the participant) of the GA genotype versus the GG genotype was 2.89 (95% confidence intervals (CI): 1.41-5.91). We conclude that a genetic polymorphism in the SLC11A1 gene plays a role in susceptibility to develop Buruli ulcer, with an estimated 13% population attributable risk.

AB - Similar to other mycobacterial diseases, susceptibility to Buruli ulcer (Mycobacterium ulcerans infection) may be determined by host genetic factors. We investigated the role of SLC11A1 (NRAMP1) in Buruli ulcer because of its associations with both tuberculosis and leprosy. We enrolled 182 Buruli ulcer patients (102 with positive laboratory confirmation) and 191 healthy neighbourhood-matched controls in Ghana, and studied three polymorphisms in the SLC11A1 gene: 3′ UTR TGTG ins/del, D543N G/A, and INT4 G/C. Finger prick blood samples from study subjects were dried on filter papers (FTA) and processed. D543N was significantly associated with Buruli ulcer: the odds ratio (adjusted for gender, age, and region of the participant) of the GA genotype versus the GG genotype was 2.89 (95% confidence intervals (CI): 1.41-5.91). We conclude that a genetic polymorphism in the SLC11A1 gene plays a role in susceptibility to develop Buruli ulcer, with an estimated 13% population attributable risk.

KW - Buruli ulcer

KW - Genetic susceptibility

KW - NRAMP1

KW - SLC11A1

U2 - 10.1038/sj.gene.6364281

DO - 10.1038/sj.gene.6364281

M3 - Article

SN - 1466-4879

VL - 7

SP - 185

EP - 189

JO - Genes and Immunity

JF - Genes and Immunity

IS - 3

ER -

Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism

Abstract

Keywords

UN SDGs

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