TY - JOUR
T1 - Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study
AU - Wang, Gang
AU - Hallberg, Jenny
AU - Charalampopoulos, Dimitrios
AU - Sanahuja, Maribel Casas
AU - Breyer-Kohansal, Robab
AU - Langhammer, Arnulf
AU - Granell, Raquel
AU - Vonk, Judith M.
AU - Mian, Annemiek
AU - Olvera, Núria
AU - Laustsen, Lisbeth Mølgaard
AU - Rönmark, Eva
AU - Abellan, Alicia
AU - Agusti, Alvar
AU - Arshad, Syed Hasan
AU - Bergström, Anna
AU - Boezen, H. Marike
AU - Breyer, Marie Kathrin
AU - Burghuber, Otto
AU - Bolund, Anneli Clea
AU - Custovic, Adnan
AU - Devereux, Graham
AU - Donaldson, Gavin C.
AU - Duijts, Liesbeth
AU - Esplugues, Ana
AU - Faner, Rosa
AU - Ballester, Ferran
AU - Garcia-Aymerich, Judith
AU - Gehring, Ulrike
AU - Haider, Sadia
AU - Hartl, Sylvia
AU - Backman, Helena
AU - Holloway, John W.
AU - Koppelman, Gerard H.
AU - Lertxundi, Aitana
AU - Holmen, Turid Lingaas
AU - Lowe, Lesley
AU - Mensink-Bout, Sara M.
AU - Murray, Clare S.
AU - Roberts, Graham
AU - Hedman, Linnea
AU - Schlünssen, Vivi
AU - Sigsgaard, Torben
AU - Simpson, Angela
AU - Sunyer, Jordi
AU - Torrent, Maties
AU - Turner, Stephen
AU - Van den Berge, Maarten
AU - Vermeulen, Roel C.H.
AU - Vikjord, Sigrid Anna Aalberg
PY - 2021/10/1
Y1 - 2021/10/1
N2 - BackgroundThe prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.MethodsWe studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10-15, >15-20, >20-25 years, and overall, 5-25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV/FVC z-score ≥LLN, and FVC z-score ResultsThe prevalence of obstructive and restrictive phenotypes varied from 3.2-10.9% and 1.8-7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14-3.04), preterm birth (aOR=1.84, 1.27-2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01-1.35) and family history of asthma (aOR=1.44, 95% CI 1.25-1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5-25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03-1.06 and aOR=0.81, 95% CI 0.78-0.85, per kg·m increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05-1.46).ConclusionObstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
AB - BackgroundThe prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.MethodsWe studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10-15, >15-20, >20-25 years, and overall, 5-25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV/FVC z-score ≥LLN, and FVC z-score ResultsThe prevalence of obstructive and restrictive phenotypes varied from 3.2-10.9% and 1.8-7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14-3.04), preterm birth (aOR=1.84, 1.27-2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01-1.35) and family history of asthma (aOR=1.44, 95% CI 1.25-1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5-25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03-1.06 and aOR=0.81, 95% CI 0.78-0.85, per kg·m increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05-1.46).ConclusionObstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
U2 - 10.1183/23120541.00457-2021
DO - 10.1183/23120541.00457-2021
M3 - Article
SN - 2312-0541
VL - 7
SP - 00457
JO - ERJ Open Research
JF - ERJ Open Research
IS - 4
M1 - 00457-2021
ER -