TY - JOUR
T1 - Short report: Serum levels of neopterin during antimicrobial treatment for mycobacterium ulcerans infection: Serum levels of neopterin during antimicrobial treatment for mycobacterium ulcerans infection
AU - De Zeeuw, Janine
AU - Duggirala, Sridevi
AU - Nienhuis, Willemien A.
AU - Abass, K. Mohammed
AU - Tuah, Wilson
AU - Omansen, Till F.
AU - Van Der Werf, Tjip S.
AU - Stienstra, Ymkje
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Neopterin is closely associated with activation of the cellular immune system. Neopterin levels differed between controls and patients with Buruli ulcer disease. No differences between patients with or without paradoxical responses were observed. Therefore, neopterin has no value in detecting paradoxical responses among patients with limited Buruli ulcer disease. Neopterin levels were lower in patients receiving clarithromycin. This finding might indicate a slower cellular immune recovery, with possible consequences in future therapy with clarithromycin.
AB - Neopterin is closely associated with activation of the cellular immune system. Neopterin levels differed between controls and patients with Buruli ulcer disease. No differences between patients with or without paradoxical responses were observed. Therefore, neopterin has no value in detecting paradoxical responses among patients with limited Buruli ulcer disease. Neopterin levels were lower in patients receiving clarithromycin. This finding might indicate a slower cellular immune recovery, with possible consequences in future therapy with clarithromycin.
U2 - 10.4269/ajtmh.12-0599
DO - 10.4269/ajtmh.12-0599
M3 - Article
VL - 89
SP - 498
EP - 500
JO - The American Journal of Tropical Medicine and Hygiene
JF - The American Journal of Tropical Medicine and Hygiene
IS - 3
ER -