Sex-based differences in clearance of chronic plasmodium falciparum infection

Jessica Briggs; Noam Teyssier; Joaniter I. Nankabirwa; John Rek; Prasanna Jagannathan; Emmanuel Arinaitwe; Teun Bousema; Chris Drakeley; Margaret Murray; Emily Crawford; Nicholas Hathaway; Sarah Staedke; David Smith; Phillip J. Rosenthal; Moses Kamya; Grant Dorsey; Isabel Rodriguez-Barraquer; Bryan Greenhouse

doi:10.7554/elife.59872

Sex-based differences in clearance of chronic plasmodium falciparum infection

Jessica Briggs, Noam Teyssier, Joaniter I. Nankabirwa, John Rek, Prasanna Jagannathan, Emmanuel Arinaitwe, Teun Bousema, Chris Drakeley, Margaret Murray, Emily Crawford, Nicholas Hathaway, Sarah Staedke, David Smith, Phillip J. Rosenthal, Moses Kamya, Grant Dorsey, Isabel Rodriguez-Barraquer, Bryan Greenhouse

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed Plasmodium falciparum infections in a cohort in a malaria endemic area of eastern Uganda and estimated both force of infection (FOI) and rate of clearance using amplicon deep-sequencing. We found no evidence of differences in behavioral risk factors, incidence of malaria, or FOI by sex. In contrast, females cleared asymptomatic infections at a faster rate than males (hazard ratio [HR]=1.82, 95% CI 1.20 to 2.75 by clone and HR = 2.07, 95% CI 1.24 to 3.47 by infection event) in multivariate models adjusted for age, timing of infection onset, and parasite density. These findings implicate biological sex-based differences as an important factor in the host response to this globally important pathogen.

Original language	English
Article number	e59872
Pages (from-to)	1-14
Number of pages	14
Journal	eLife
Volume	9
DOIs	https://doi.org/10.7554/elife.59872
Publication status	Published - 1 Oct 2020
Externally published	Yes

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Briggs, J., Teyssier, N., Nankabirwa, J. I., Rek, J., Jagannathan, P., Arinaitwe, E., Bousema, T., Drakeley, C., Murray, M., Crawford, E., Hathaway, N., Staedke, S., Smith, D., Rosenthal, P. J., Kamya, M., Dorsey, G., Rodriguez-Barraquer, I., & Greenhouse, B. (2020). Sex-based differences in clearance of chronic plasmodium falciparum infection. eLife, 9, 1-14. Article e59872. https://doi.org/10.7554/elife.59872

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title = "Sex-based differences in clearance of chronic plasmodium falciparum infection",

abstract = "Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed Plasmodium falciparum infections in a cohort in a malaria endemic area of eastern Uganda and estimated both force of infection (FOI) and rate of clearance using amplicon deep-sequencing. We found no evidence of differences in behavioral risk factors, incidence of malaria, or FOI by sex. In contrast, females cleared asymptomatic infections at a faster rate than males (hazard ratio [HR]=1.82, 95\% CI 1.20 to 2.75 by clone and HR = 2.07, 95\% CI 1.24 to 3.47 by infection event) in multivariate models adjusted for age, timing of infection onset, and parasite density. These findings implicate biological sex-based differences as an important factor in the host response to this globally important pathogen.",

author = "Jessica Briggs and Noam Teyssier and Nankabirwa, \{Joaniter I.\} and John Rek and Prasanna Jagannathan and Emmanuel Arinaitwe and Teun Bousema and Chris Drakeley and Margaret Murray and Emily Crawford and Nicholas Hathaway and Sarah Staedke and David Smith and Rosenthal, \{Phillip J.\} and Moses Kamya and Grant Dorsey and Isabel Rodriguez-Barraquer and Bryan Greenhouse",

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doi = "10.7554/elife.59872",

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Briggs, J, Teyssier, N, Nankabirwa, JI, Rek, J, Jagannathan, P, Arinaitwe, E, Bousema, T, Drakeley, C, Murray, M, Crawford, E, Hathaway, N, Staedke, S, Smith, D, Rosenthal, PJ, Kamya, M, Dorsey, G, Rodriguez-Barraquer, I & Greenhouse, B 2020, 'Sex-based differences in clearance of chronic plasmodium falciparum infection', eLife, vol. 9, e59872, pp. 1-14. https://doi.org/10.7554/elife.59872

TY - JOUR

T1 - Sex-based differences in clearance of chronic plasmodium falciparum infection

AU - Briggs, Jessica

AU - Teyssier, Noam

AU - Nankabirwa, Joaniter I.

AU - Rek, John

AU - Jagannathan, Prasanna

AU - Arinaitwe, Emmanuel

AU - Bousema, Teun

AU - Drakeley, Chris

AU - Murray, Margaret

AU - Crawford, Emily

AU - Hathaway, Nicholas

AU - Staedke, Sarah

AU - Smith, David

AU - Rosenthal, Phillip J.

AU - Kamya, Moses

AU - Dorsey, Grant

AU - Rodriguez-Barraquer, Isabel

AU - Greenhouse, Bryan

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed Plasmodium falciparum infections in a cohort in a malaria endemic area of eastern Uganda and estimated both force of infection (FOI) and rate of clearance using amplicon deep-sequencing. We found no evidence of differences in behavioral risk factors, incidence of malaria, or FOI by sex. In contrast, females cleared asymptomatic infections at a faster rate than males (hazard ratio [HR]=1.82, 95% CI 1.20 to 2.75 by clone and HR = 2.07, 95% CI 1.24 to 3.47 by infection event) in multivariate models adjusted for age, timing of infection onset, and parasite density. These findings implicate biological sex-based differences as an important factor in the host response to this globally important pathogen.

AB - Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed Plasmodium falciparum infections in a cohort in a malaria endemic area of eastern Uganda and estimated both force of infection (FOI) and rate of clearance using amplicon deep-sequencing. We found no evidence of differences in behavioral risk factors, incidence of malaria, or FOI by sex. In contrast, females cleared asymptomatic infections at a faster rate than males (hazard ratio [HR]=1.82, 95% CI 1.20 to 2.75 by clone and HR = 2.07, 95% CI 1.24 to 3.47 by infection event) in multivariate models adjusted for age, timing of infection onset, and parasite density. These findings implicate biological sex-based differences as an important factor in the host response to this globally important pathogen.

U2 - 10.7554/elife.59872

DO - 10.7554/elife.59872

M3 - Article

SN - 2050-084X

VL - 9

SP - 1

EP - 14

JO - eLife

JF - eLife

M1 - e59872

ER -

Sex-based differences in clearance of chronic plasmodium falciparum infection

Abstract

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