Serum antibody response in patients with mild Typhoid fever from southern Vietnam

D. L. House; H. Vinh; N. T. Chinh; J. R. Wain; Christopher Parry; N. T. Quyen; T. S. Diep; T. T. Hien; J. J. Farrar; N. J. White; G. Dougan

doi:10.13181/mji.v7isupp1.1133

Serum antibody response in patients with mild Typhoid fever from southern Vietnam

D. L. House, H. Vinh, N. T. Chinh, J. R. Wain, Christopher Parry, N. T. Quyen, T. S. Diep, T. T. Hien, J. J. Farrar, N. J. White, G. Dougan

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this study was to describe the antibody response to Salmonella typhi (S. typhij antigens (lipolysaccharide (LPS), flagella, Vi) m patients with non-severe typhoid fever from an endemic region. Acute serum samples were obtained from 164 patients with blood culture proven typhoid fever. Serum levels of anti-LPS (total Immunoglobulin (Ig), IgA, IgG, IgM), anti-flagella (total Ig, IgG) and anti-Vi (total Ig, IgG) antibodies were determined. Inter-individual variation was high for all antibody-antigen combinations investigated. Correlation analyses showed this was due, in part, to differences in age and duration of fever. Some patients had relatively low antibody levels despite a long history of illness, particularly children. Our results suggest that serological diagnostic tests based on the antigens used in this study may have limited sensitivity, particularly in young children, in patient with a short history of illness, and in those living in endemic areas.

Original language	English
Pages (from-to)	269-270
Number of pages	2
Journal	Medical Journal of Indonesia
Volume	7
DOIs	https://doi.org/10.13181/mji.v7isupp1.1133
Publication status	Published - 1 Jan 1998
Externally published	Yes

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@article{d201501b16794e29a559c391dbc6f546,

title = "Serum antibody response in patients with mild Typhoid fever from southern Vietnam",

abstract = "The aim of this study was to describe the antibody response to Salmonella typhi (S. typhij antigens (lipolysaccharide (LPS), flagella, Vi) m patients with non-severe typhoid fever from an endemic region. Acute serum samples were obtained from 164 patients with blood culture proven typhoid fever. Serum levels of anti-LPS (total Immunoglobulin (Ig), IgA, IgG, IgM), anti-flagella (total Ig, IgG) and anti-Vi (total Ig, IgG) antibodies were determined. Inter-individual variation was high for all antibody-antigen combinations investigated. Correlation analyses showed this was due, in part, to differences in age and duration of fever. Some patients had relatively low antibody levels despite a long history of illness, particularly children. Our results suggest that serological diagnostic tests based on the antigens used in this study may have limited sensitivity, particularly in young children, in patient with a short history of illness, and in those living in endemic areas.",

author = "House, \{D. L.\} and H. Vinh and Chinh, \{N. T.\} and Wain, \{J. R.\} and Christopher Parry and Quyen, \{N. T.\} and Diep, \{T. S.\} and Hien, \{T. T.\} and Farrar, \{J. J.\} and White, \{N. J.\} and G. Dougan",

year = "1998",

month = jan,

day = "1",

doi = "10.13181/mji.v7isupp1.1133",

language = "English",

volume = "7",

pages = "269--270",

journal = "Medical Journal of Indonesia",

issn = "0853-1773",

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TY - JOUR

T1 - Serum antibody response in patients with mild Typhoid fever from southern Vietnam

AU - House, D. L.

AU - Vinh, H.

AU - Chinh, N. T.

AU - Wain, J. R.

AU - Parry, Christopher

AU - Quyen, N. T.

AU - Diep, T. S.

AU - Hien, T. T.

AU - Farrar, J. J.

AU - White, N. J.

AU - Dougan, G.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - The aim of this study was to describe the antibody response to Salmonella typhi (S. typhij antigens (lipolysaccharide (LPS), flagella, Vi) m patients with non-severe typhoid fever from an endemic region. Acute serum samples were obtained from 164 patients with blood culture proven typhoid fever. Serum levels of anti-LPS (total Immunoglobulin (Ig), IgA, IgG, IgM), anti-flagella (total Ig, IgG) and anti-Vi (total Ig, IgG) antibodies were determined. Inter-individual variation was high for all antibody-antigen combinations investigated. Correlation analyses showed this was due, in part, to differences in age and duration of fever. Some patients had relatively low antibody levels despite a long history of illness, particularly children. Our results suggest that serological diagnostic tests based on the antigens used in this study may have limited sensitivity, particularly in young children, in patient with a short history of illness, and in those living in endemic areas.

AB - The aim of this study was to describe the antibody response to Salmonella typhi (S. typhij antigens (lipolysaccharide (LPS), flagella, Vi) m patients with non-severe typhoid fever from an endemic region. Acute serum samples were obtained from 164 patients with blood culture proven typhoid fever. Serum levels of anti-LPS (total Immunoglobulin (Ig), IgA, IgG, IgM), anti-flagella (total Ig, IgG) and anti-Vi (total Ig, IgG) antibodies were determined. Inter-individual variation was high for all antibody-antigen combinations investigated. Correlation analyses showed this was due, in part, to differences in age and duration of fever. Some patients had relatively low antibody levels despite a long history of illness, particularly children. Our results suggest that serological diagnostic tests based on the antigens used in this study may have limited sensitivity, particularly in young children, in patient with a short history of illness, and in those living in endemic areas.

U2 - 10.13181/mji.v7isupp1.1133

DO - 10.13181/mji.v7isupp1.1133

M3 - Article

SN - 0853-1773

VL - 7

SP - 269

EP - 270

JO - Medical Journal of Indonesia

JF - Medical Journal of Indonesia

ER -

Serum antibody response in patients with mild Typhoid fever from southern Vietnam

Abstract

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