Serology describes a profile of declining malaria transmission in Farafenni, The Gambia

Lotus L. Van Den Hoogen; Jamie T. Griffin; Jackie Cook; Nuno Sepúlveda; Patrick Corran; David J. Conway; Paul Milligan; Muna Affara; Stephen Allen; Carla Proietti; Serign J. Ceesay; Geoffrey A. Targett; Umberto D'Alessandro; Brian Greenwood; Eleanor M. Riley; Chris Drakeley

doi:10.1186/s12936-015-0939-1

Serology describes a profile of declining malaria transmission in Farafenni, The Gambia

Lotus L. Van Den Hoogen, Jamie T. Griffin, Jackie Cook, Nuno Sepúlveda, Patrick Corran, David J. Conway, Paul Milligan, Muna Affara, Stephen Allen, Carla Proietti, Serign J. Ceesay, Geoffrey A. Targett, Umberto D'Alessandro, Brian Greenwood, Eleanor M. Riley, Chris Drakeley

Clinical Sciences

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Background

Malaria morbidity and mortality has declined in recent years in a number of settings. The ability to describe changes in malaria transmission associated with these declines is important in terms of assessing the potential effects of control interventions, and for monitoring and evaluation purposes.

Methods

Data from five cross-sectional surveys conducted in Farafenni and surrounding villages on the north bank of River Gambia between 1988 and 2011 were compiled. Antibody responses to MSP-1 19 were measured in samples from all surveys, data were normalized and expressed as seroprevalence and seroconversion rates (SCR) using different mathematical models.

Results

Results showed declines in serological metrics with seroprevalence in children aged one to 5 years dropping from 19 % (95 % CI 15–23 %) in 1988 to 1 % (0–2 %) in 2011 (p value for trend in proportions < 0.001) and the SCR dropping from 0.069 year −1 (0.059–0.080) to 0.022 year −1 (0.017–0.028; p = 0.004). The serological data were consistent with previously described drops in both parasite prevalence in children aged 1–5 years (62 %, 57–66 %, in 1988 to 2 %, 0–4 %, in 2011; p < 0.001), and all-cause under five mortality rates (37 per 1000 person-years, 34–41, in 1990 to 17, 15–19, in 2006; p = 0.059).

Conclusions

This analysis shows accurate reconstruction of historical malaria transmission patterns in the Farafenni area using anti-malarial antibody responses. Demonstrating congruence between serological measures, and conventional clinical and parasitological measures suggests broader utility for serology in monitoring and evaluation of malaria transmission.

Original language	English
Article number	416
Journal	Malaria Journal
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/s12936-015-0939-1
Publication status	Published - 22 Oct 2015

Keywords

Malaria
MSP-1
Plasmodium falciparum
Serology
Transmission

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12936-015-0939-1Licence: CC BY

Malar J 14 416 Serology describes a profileFinal published version, 1.22 MBLicence: CC BY

Cite this

Van Den Hoogen, L. L., Griffin, J. T., Cook, J., Sepúlveda, N., Corran, P., Conway, D. J., Milligan, P., Affara, M., Allen, S., Proietti, C., Ceesay, S. J., Targett, G. A., D'Alessandro, U., Greenwood, B., Riley, E. M., & Drakeley, C. (2015). Serology describes a profile of declining malaria transmission in Farafenni, The Gambia. Malaria Journal, 14(1), Article 416. https://doi.org/10.1186/s12936-015-0939-1

@article{d0ff7533fb0d435896bc3e5173cf2037,

title = "Serology describes a profile of declining malaria transmission in Farafenni, The Gambia",

abstract = "BackgroundMalaria morbidity and mortality has declined in recent years in a number of settings. The ability to describe changes in malaria transmission associated with these declines is important in terms of assessing the potential effects of control interventions, and for monitoring and evaluation purposes.MethodsData from five cross-sectional surveys conducted in Farafenni and surrounding villages on the north bank of River Gambia between 1988 and 2011 were compiled. Antibody responses to MSP-1 19 were measured in samples from all surveys, data were normalized and expressed as seroprevalence and seroconversion rates (SCR) using different mathematical models.ResultsResults showed declines in serological metrics with seroprevalence in children aged one to 5 years dropping from 19 \% (95 \% CI 15–23 \%) in 1988 to 1 \% (0–2 \%) in 2011 (p value for trend in proportions < 0.001) and the SCR dropping from 0.069 year −1 (0.059–0.080) to 0.022 year −1 (0.017–0.028; p = 0.004). The serological data were consistent with previously described drops in both parasite prevalence in children aged 1–5 years (62 \%, 57–66 \%, in 1988 to 2 \%, 0–4 \%, in 2011; p < 0.001), and all-cause under five mortality rates (37 per 1000 person-years, 34–41, in 1990 to 17, 15–19, in 2006; p = 0.059).ConclusionsThis analysis shows accurate reconstruction of historical malaria transmission patterns in the Farafenni area using anti-malarial antibody responses. Demonstrating congruence between serological measures, and conventional clinical and parasitological measures suggests broader utility for serology in monitoring and evaluation of malaria transmission.",

keywords = "Malaria, MSP-1, Plasmodium falciparum, Serology, Transmission",

author = "\{Van Den Hoogen\}, \{Lotus L.\} and Griffin, \{Jamie T.\} and Jackie Cook and Nuno Sep{\'u}lveda and Patrick Corran and Conway, \{David J.\} and Paul Milligan and Muna Affara and Stephen Allen and Carla Proietti and Ceesay, \{Serign J.\} and Targett, \{Geoffrey A.\} and Umberto D'Alessandro and Brian Greenwood and Riley, \{Eleanor M.\} and Chris Drakeley",

year = "2015",

month = oct,

day = "22",

doi = "10.1186/s12936-015-0939-1",

language = "English",

volume = "14",

journal = "Malaria Journal",

issn = "1475-2875",

publisher = "BioMed Central Ltd",

number = "1",

}

Van Den Hoogen, LL, Griffin, JT, Cook, J, Sepúlveda, N, Corran, P, Conway, DJ, Milligan, P, Affara, M, Allen, S, Proietti, C, Ceesay, SJ, Targett, GA, D'Alessandro, U, Greenwood, B, Riley, EM & Drakeley, C 2015, 'Serology describes a profile of declining malaria transmission in Farafenni, The Gambia', Malaria Journal, vol. 14, no. 1, 416. https://doi.org/10.1186/s12936-015-0939-1

TY - JOUR

T1 - Serology describes a profile of declining malaria transmission in Farafenni, The Gambia

AU - Van Den Hoogen, Lotus L.

AU - Griffin, Jamie T.

AU - Cook, Jackie

AU - Sepúlveda, Nuno

AU - Corran, Patrick

AU - Conway, David J.

AU - Milligan, Paul

AU - Affara, Muna

AU - Allen, Stephen

AU - Proietti, Carla

AU - Ceesay, Serign J.

AU - Targett, Geoffrey A.

AU - D'Alessandro, Umberto

AU - Greenwood, Brian

AU - Riley, Eleanor M.

AU - Drakeley, Chris

PY - 2015/10/22

Y1 - 2015/10/22

N2 - BackgroundMalaria morbidity and mortality has declined in recent years in a number of settings. The ability to describe changes in malaria transmission associated with these declines is important in terms of assessing the potential effects of control interventions, and for monitoring and evaluation purposes.MethodsData from five cross-sectional surveys conducted in Farafenni and surrounding villages on the north bank of River Gambia between 1988 and 2011 were compiled. Antibody responses to MSP-1 19 were measured in samples from all surveys, data were normalized and expressed as seroprevalence and seroconversion rates (SCR) using different mathematical models.ResultsResults showed declines in serological metrics with seroprevalence in children aged one to 5 years dropping from 19 % (95 % CI 15–23 %) in 1988 to 1 % (0–2 %) in 2011 (p value for trend in proportions < 0.001) and the SCR dropping from 0.069 year −1 (0.059–0.080) to 0.022 year −1 (0.017–0.028; p = 0.004). The serological data were consistent with previously described drops in both parasite prevalence in children aged 1–5 years (62 %, 57–66 %, in 1988 to 2 %, 0–4 %, in 2011; p < 0.001), and all-cause under five mortality rates (37 per 1000 person-years, 34–41, in 1990 to 17, 15–19, in 2006; p = 0.059).ConclusionsThis analysis shows accurate reconstruction of historical malaria transmission patterns in the Farafenni area using anti-malarial antibody responses. Demonstrating congruence between serological measures, and conventional clinical and parasitological measures suggests broader utility for serology in monitoring and evaluation of malaria transmission.

AB - BackgroundMalaria morbidity and mortality has declined in recent years in a number of settings. The ability to describe changes in malaria transmission associated with these declines is important in terms of assessing the potential effects of control interventions, and for monitoring and evaluation purposes.MethodsData from five cross-sectional surveys conducted in Farafenni and surrounding villages on the north bank of River Gambia between 1988 and 2011 were compiled. Antibody responses to MSP-1 19 were measured in samples from all surveys, data were normalized and expressed as seroprevalence and seroconversion rates (SCR) using different mathematical models.ResultsResults showed declines in serological metrics with seroprevalence in children aged one to 5 years dropping from 19 % (95 % CI 15–23 %) in 1988 to 1 % (0–2 %) in 2011 (p value for trend in proportions < 0.001) and the SCR dropping from 0.069 year −1 (0.059–0.080) to 0.022 year −1 (0.017–0.028; p = 0.004). The serological data were consistent with previously described drops in both parasite prevalence in children aged 1–5 years (62 %, 57–66 %, in 1988 to 2 %, 0–4 %, in 2011; p < 0.001), and all-cause under five mortality rates (37 per 1000 person-years, 34–41, in 1990 to 17, 15–19, in 2006; p = 0.059).ConclusionsThis analysis shows accurate reconstruction of historical malaria transmission patterns in the Farafenni area using anti-malarial antibody responses. Demonstrating congruence between serological measures, and conventional clinical and parasitological measures suggests broader utility for serology in monitoring and evaluation of malaria transmission.

KW - Malaria

KW - MSP-1

KW - Plasmodium falciparum

KW - Serology

KW - Transmission

U2 - 10.1186/s12936-015-0939-1

DO - 10.1186/s12936-015-0939-1

M3 - Article

SN - 1475-2875

VL - 14

JO - Malaria Journal

JF - Malaria Journal

IS - 1

M1 - 416

ER -

Serology describes a profile of declining malaria transmission in Farafenni, The Gambia

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this