Serological similarities between hyperreactive malarial splenomegaly and splenic lymphoma in West Africa

S. Wallace; G. Bedu-Addo; T. R. Rutherford; Imelda Bates

doi:10.1016/s0035-9203(98)91095-1

Serological similarities between hyperreactive malarial splenomegaly and splenic lymphoma in West Africa

S. Wallace, G. Bedu-Addo, T. R. Rutherford, Imelda Bates

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

In West Africa hyperreactive malarial splenomegaly (HMS) and splenic lymphoma with villous lymphocytes (SLVL) are demographically and clinically indistinguishable. Determination of lymphocyte clonality is needed to differentiate clearly between these 2 disorders. To obtain evidence to support our hypothesis that HMS and SLVL are aetiologically related we studied the serological profile of malaria-related antibodies in HMS and SLVL in West Africa. We found that in SLVL total immunoglobulin M and antimalarial antibody levels were markedly raised, a combination which is characteristic of HMS. These findings strongly support a developmental relationship between HMS and SLVL in tropical Africa and implicate malaria in this process.

Original language	English
Pages (from-to)	463-467
Number of pages	5
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	92
Issue number	4
DOIs	https://doi.org/10.1016/s0035-9203(98)91095-1
Publication status	Published - 1 Jan 1998
Externally published	Yes

Keywords

Ghana
Hyperreactive malarial splenomegaly
Malaria
Plasmodium falciparum
Splenic lymphoma with villous lymphocytes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s0035-9203(98)91095-1

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title = "Serological similarities between hyperreactive malarial splenomegaly and splenic lymphoma in West Africa",

abstract = "In West Africa hyperreactive malarial splenomegaly (HMS) and splenic lymphoma with villous lymphocytes (SLVL) are demographically and clinically indistinguishable. Determination of lymphocyte clonality is needed to differentiate clearly between these 2 disorders. To obtain evidence to support our hypothesis that HMS and SLVL are aetiologically related we studied the serological profile of malaria-related antibodies in HMS and SLVL in West Africa. We found that in SLVL total immunoglobulin M and antimalarial antibody levels were markedly raised, a combination which is characteristic of HMS. These findings strongly support a developmental relationship between HMS and SLVL in tropical Africa and implicate malaria in this process.",

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author = "S. Wallace and G. Bedu-Addo and Rutherford, \{T. R.\} and Imelda Bates",

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T1 - Serological similarities between hyperreactive malarial splenomegaly and splenic lymphoma in West Africa

AU - Wallace, S.

AU - Bedu-Addo, G.

AU - Rutherford, T. R.

AU - Bates, Imelda

PY - 1998/1/1

Y1 - 1998/1/1

N2 - In West Africa hyperreactive malarial splenomegaly (HMS) and splenic lymphoma with villous lymphocytes (SLVL) are demographically and clinically indistinguishable. Determination of lymphocyte clonality is needed to differentiate clearly between these 2 disorders. To obtain evidence to support our hypothesis that HMS and SLVL are aetiologically related we studied the serological profile of malaria-related antibodies in HMS and SLVL in West Africa. We found that in SLVL total immunoglobulin M and antimalarial antibody levels were markedly raised, a combination which is characteristic of HMS. These findings strongly support a developmental relationship between HMS and SLVL in tropical Africa and implicate malaria in this process.

AB - In West Africa hyperreactive malarial splenomegaly (HMS) and splenic lymphoma with villous lymphocytes (SLVL) are demographically and clinically indistinguishable. Determination of lymphocyte clonality is needed to differentiate clearly between these 2 disorders. To obtain evidence to support our hypothesis that HMS and SLVL are aetiologically related we studied the serological profile of malaria-related antibodies in HMS and SLVL in West Africa. We found that in SLVL total immunoglobulin M and antimalarial antibody levels were markedly raised, a combination which is characteristic of HMS. These findings strongly support a developmental relationship between HMS and SLVL in tropical Africa and implicate malaria in this process.

KW - Ghana

KW - Hyperreactive malarial splenomegaly

KW - Malaria

KW - Plasmodium falciparum

KW - Splenic lymphoma with villous lymphocytes

U2 - 10.1016/s0035-9203(98)91095-1

DO - 10.1016/s0035-9203(98)91095-1

M3 - Article

SN - 0035-9203

VL - 92

SP - 463

EP - 467

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 4

ER -

Serological similarities between hyperreactive malarial splenomegaly and splenic lymphoma in West Africa

Abstract

Keywords

UN SDGs

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