Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

Peter Arensburger; Karine Megy; Robert M. Waterhouse; Jenica Abrudan; Paolo Amedeo; Beatriz Antelo; Lyric Bartholomay; Shelby Bidwell; Elisabet Caler; Francisco Camara; Corey L. Campbell; Kathryn S. Campbell; Claudio Casola; Marta T. Castro; Ishwar Chandramouliswaran; Sinéad B. Chapman; Scott Christley; Javier Costas; Eric Eisenstadt; Cedric Feschotte; Claire Fraser-Liggett; Roderic Guigo; Brian Haas; Martin Hammond; Bill S. Hansson; Janet Hemingway; Sharon R. Hill; Clint Howarth; Rickard Ignell; Ryan C. Kennedy; Chinnappa D. Kodira; Neil F. Lobo; Chunhong Mao; George Mayhew; Kristin Michel; Akio Mori; Nannan Liu; Horacio Naveira; Vishvanath Nene; Nam Nguyen; Matthew D. Pearson; Ellen J. Pritham; Daniela Puiu; Yumin Qi; Hilary Ranson; Jose M.C. Ribeiro; Hugh M. Roberston; David W. Severson; Martin Shumway; Mario Stanke; Robert L. Strausberg; Cheng Sun; Granger Sutton; Zhijian Tu; Jose Manuel C. Tubio; Maria F. Unger; Dana L. Vanlandingham; Albert J. Vilella; Owen White; Jared R. White; Charles Wondji; Jennifer Wortman; Evgeny M. Zdobnov; Bruce Birren; Bruce M. Christensen; Frank H. Collins; Anthony Cornel; George Dimopoulos; Linda I. Hannick; Stephen Higgs; Gregory C. Lanzaro; Daniel Lawson; Norman H. Lee; Marc A.T. Muskavitch; Alexander S. Raikhel; Peter W. Atkinson

doi:10.1126/science.1191864

Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

Peter Arensburger
, Karine Megy
, Robert M. Waterhouse
, Jenica Abrudan
, Paolo Amedeo
, Beatriz Antelo
, Lyric Bartholomay
, Shelby Bidwell
, Elisabet Caler
, Francisco Camara
, Corey L. Campbell
, Kathryn S. Campbell
, Claudio Casola
, Marta T. Castro
, Ishwar Chandramouliswaran
, Sinéad B. Chapman
, Scott Christley
, Javier Costas
, Eric Eisenstadt
, Cedric Feschotte

Claire Fraser-Liggett, Roderic Guigo, Brian Haas, Martin Hammond, Bill S. Hansson, Janet Hemingway, Sharon R. Hill, Clint Howarth, Rickard Ignell, Ryan C. Kennedy, Chinnappa D. Kodira, Neil F. Lobo, Chunhong Mao, George Mayhew, Kristin Michel, Akio Mori, Nannan Liu, Horacio Naveira, Vishvanath Nene, Nam Nguyen, Matthew D. Pearson, Ellen J. Pritham, Daniela Puiu, Yumin Qi, Hilary Ranson, Jose M.C. Ribeiro, Hugh M. Roberston, David W. Severson, Martin Shumway, Mario Stanke, Robert L. Strausberg, Cheng Sun, Granger Sutton, Zhijian Tu, Jose Manuel C. Tubio, Maria F. Unger, Dana L. Vanlandingham, Albert J. Vilella, Owen White, Jared R. White, Charles Wondji, Jennifer Wortman, Evgeny M. Zdobnov, Bruce Birren, Bruce M. Christensen, Frank H. Collins, Anthony Cornel, George Dimopoulos, Linda I. Hannick, Stephen Higgs, Gregory C. Lanzaro, Daniel Lawson, Norman H. Lee, Marc A.T. Muskavitch, Alexander S. Raikhel, Peter W. Atkinson

Vector Biology

University of California at Riverside
European Molecular Biology Laboratory
University of Geneva
Swiss Institute of Bioinformatics
University of Notre Dame
J. Craig Venter Institute
Complejo Hospitalario Universitario de Santiago
Iowa State University
The Barcelona Institute for Science and Technology
Colorado State University
Harvard University
Indiana University Bloomington
Hospital Durán i Reynals
Broad Institute
Fundación Pública Galega de Medicina Xenómica
University of Texas at Arlington
University of Maryland, Baltimore
Max Planck Institute for Chemical Ecology
Swedish University of Agricultural Sciences
454 Life Sciences, Roche Group
Virginia Polytechnic Institute and State University
University of Wisconsin-Madison
Kansas State University
Auburn University
University of A Coruna
International Livestock Research Institute
University of Maryland, College Park
National Institutes of Health
University of Illinois Urbana-Champaign
University of Göttingen
Imperial College London
University of Texas Medical Branch at Galveston
Johns Hopkins University
University of California at Davis
George Washington University
Boston College

Research output: Contribution to journal › Article › peer-review

399 Citations (Scopus)

Abstract

Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as well as of nematodes that cause lymphatic filariasis. C. quinquefasciatus is one species within the Culex pipiens species complex and can be found throughout ropical and temperate climates of the world. The ability of C. quinquefasciatus to take blood meals from birds, livestock, and humans contributes to its ability to vector pathogens between species. Here, we describe the genomic sequence of C. quinquefasciatus: Its repertoire of 18,883 protein-coding genes is 22% larger than that of Aedes aegypti and 52% larger than that of Anopheles gambiae with multiple gene-family expansions, including olfactory and gustatory receptors, salivary gland genes, and genes associated with xenobiotic detoxification.

Original language	English
Pages (from-to)	86-88
Number of pages	3
Journal	Science
Volume	330
Issue number	6000
DOIs	https://doi.org/10.1126/science.1191864
Publication status	Published - 1 Oct 2010

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Arensburger, P., Megy, K., Waterhouse, R. M., Abrudan, J., Amedeo, P., Antelo, B., Bartholomay, L., Bidwell, S., Caler, E., Camara, F., Campbell, C. L., Campbell, K. S., Casola, C., Castro, M. T., Chandramouliswaran, I., Chapman, S. B., Christley, S., Costas, J., Eisenstadt, E., ... Atkinson, P. W. (2010). Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics. Science, 330(6000), 86-88. https://doi.org/10.1126/science.1191864

@article{73169d155e7f4c80bd3c68abb80839fc,

title = "Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics",

abstract = "Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as well as of nematodes that cause lymphatic filariasis. C. quinquefasciatus is one species within the Culex pipiens species complex and can be found throughout ropical and temperate climates of the world. The ability of C. quinquefasciatus to take blood meals from birds, livestock, and humans contributes to its ability to vector pathogens between species. Here, we describe the genomic sequence of C. quinquefasciatus: Its repertoire of 18,883 protein-coding genes is 22\% larger than that of Aedes aegypti and 52\% larger than that of Anopheles gambiae with multiple gene-family expansions, including olfactory and gustatory receptors, salivary gland genes, and genes associated with xenobiotic detoxification.",

author = "Peter Arensburger and Karine Megy and Waterhouse, \{Robert M.\} and Jenica Abrudan and Paolo Amedeo and Beatriz Antelo and Lyric Bartholomay and Shelby Bidwell and Elisabet Caler and Francisco Camara and Campbell, \{Corey L.\} and Campbell, \{Kathryn S.\} and Claudio Casola and Castro, \{Marta T.\} and Ishwar Chandramouliswaran and Chapman, \{Sin{\'e}ad B.\} and Scott Christley and Javier Costas and Eric Eisenstadt and Cedric Feschotte and Claire Fraser-Liggett and Roderic Guigo and Brian Haas and Martin Hammond and Hansson, \{Bill S.\} and Janet Hemingway and Hill, \{Sharon R.\} and Clint Howarth and Rickard Ignell and Kennedy, \{Ryan C.\} and Kodira, \{Chinnappa D.\} and Lobo, \{Neil F.\} and Chunhong Mao and George Mayhew and Kristin Michel and Akio Mori and Nannan Liu and Horacio Naveira and Vishvanath Nene and Nam Nguyen and Pearson, \{Matthew D.\} and Pritham, \{Ellen J.\} and Daniela Puiu and Yumin Qi and Hilary Ranson and Ribeiro, \{Jose M.C.\} and Roberston, \{Hugh M.\} and Severson, \{David W.\} and Martin Shumway and Mario Stanke and Strausberg, \{Robert L.\} and Cheng Sun and Granger Sutton and Zhijian Tu and Tubio, \{Jose Manuel C.\} and Unger, \{Maria F.\} and Vanlandingham, \{Dana L.\} and Vilella, \{Albert J.\} and Owen White and White, \{Jared R.\} and Charles Wondji and Jennifer Wortman and Zdobnov, \{Evgeny M.\} and Bruce Birren and Christensen, \{Bruce M.\} and Collins, \{Frank H.\} and Anthony Cornel and George Dimopoulos and Hannick, \{Linda I.\} and Stephen Higgs and Lanzaro, \{Gregory C.\} and Daniel Lawson and Lee, \{Norman H.\} and Muskavitch, \{Marc A.T.\} and Raikhel, \{Alexander S.\} and Atkinson, \{Peter W.\}",

year = "2010",

month = oct,

day = "1",

doi = "10.1126/science.1191864",

language = "English",

volume = "330",

pages = "86--88",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6000",

}

Arensburger, P, Megy, K, Waterhouse, RM, Abrudan, J, Amedeo, P, Antelo, B, Bartholomay, L, Bidwell, S, Caler, E, Camara, F, Campbell, CL, Campbell, KS, Casola, C, Castro, MT, Chandramouliswaran, I, Chapman, SB, Christley, S, Costas, J, Eisenstadt, E, Feschotte, C, Fraser-Liggett, C, Guigo, R, Haas, B, Hammond, M, Hansson, BS, Hemingway, J, Hill, SR, Howarth, C, Ignell, R, Kennedy, RC, Kodira, CD, Lobo, NF, Mao, C, Mayhew, G, Michel, K, Mori, A, Liu, N, Naveira, H, Nene, V, Nguyen, N, Pearson, MD, Pritham, EJ, Puiu, D, Qi, Y, Ranson, H, Ribeiro, JMC, Roberston, HM, Severson, DW, Shumway, M, Stanke, M, Strausberg, RL, Sun, C, Sutton, G, Tu, Z, Tubio, JMC, Unger, MF, Vanlandingham, DL, Vilella, AJ, White, O, White, JR, Wondji, C, Wortman, J, Zdobnov, EM, Birren, B, Christensen, BM, Collins, FH, Cornel, A, Dimopoulos, G, Hannick, LI, Higgs, S, Lanzaro, GC, Lawson, D, Lee, NH, Muskavitch, MAT, Raikhel, AS & Atkinson, PW 2010, 'Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics', Science, vol. 330, no. 6000, pp. 86-88. https://doi.org/10.1126/science.1191864

TY - JOUR

T1 - Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

AU - Arensburger, Peter

AU - Megy, Karine

AU - Waterhouse, Robert M.

AU - Abrudan, Jenica

AU - Amedeo, Paolo

AU - Antelo, Beatriz

AU - Bartholomay, Lyric

AU - Bidwell, Shelby

AU - Caler, Elisabet

AU - Camara, Francisco

AU - Campbell, Corey L.

AU - Campbell, Kathryn S.

AU - Casola, Claudio

AU - Castro, Marta T.

AU - Chandramouliswaran, Ishwar

AU - Chapman, Sinéad B.

AU - Christley, Scott

AU - Costas, Javier

AU - Eisenstadt, Eric

AU - Feschotte, Cedric

AU - Fraser-Liggett, Claire

AU - Guigo, Roderic

AU - Haas, Brian

AU - Hammond, Martin

AU - Hansson, Bill S.

AU - Hemingway, Janet

AU - Hill, Sharon R.

AU - Howarth, Clint

AU - Ignell, Rickard

AU - Kennedy, Ryan C.

AU - Kodira, Chinnappa D.

AU - Lobo, Neil F.

AU - Mao, Chunhong

AU - Mayhew, George

AU - Michel, Kristin

AU - Mori, Akio

AU - Liu, Nannan

AU - Naveira, Horacio

AU - Nene, Vishvanath

AU - Nguyen, Nam

AU - Pearson, Matthew D.

AU - Pritham, Ellen J.

AU - Puiu, Daniela

AU - Qi, Yumin

AU - Ranson, Hilary

AU - Ribeiro, Jose M.C.

AU - Roberston, Hugh M.

AU - Severson, David W.

AU - Shumway, Martin

AU - Stanke, Mario

AU - Strausberg, Robert L.

AU - Sun, Cheng

AU - Sutton, Granger

AU - Tu, Zhijian

AU - Tubio, Jose Manuel C.

AU - Unger, Maria F.

AU - Vanlandingham, Dana L.

AU - Vilella, Albert J.

AU - White, Owen

AU - White, Jared R.

AU - Wondji, Charles

AU - Wortman, Jennifer

AU - Zdobnov, Evgeny M.

AU - Birren, Bruce

AU - Christensen, Bruce M.

AU - Collins, Frank H.

AU - Cornel, Anthony

AU - Dimopoulos, George

AU - Hannick, Linda I.

AU - Higgs, Stephen

AU - Lanzaro, Gregory C.

AU - Lawson, Daniel

AU - Lee, Norman H.

AU - Muskavitch, Marc A.T.

AU - Raikhel, Alexander S.

AU - Atkinson, Peter W.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as well as of nematodes that cause lymphatic filariasis. C. quinquefasciatus is one species within the Culex pipiens species complex and can be found throughout ropical and temperate climates of the world. The ability of C. quinquefasciatus to take blood meals from birds, livestock, and humans contributes to its ability to vector pathogens between species. Here, we describe the genomic sequence of C. quinquefasciatus: Its repertoire of 18,883 protein-coding genes is 22% larger than that of Aedes aegypti and 52% larger than that of Anopheles gambiae with multiple gene-family expansions, including olfactory and gustatory receptors, salivary gland genes, and genes associated with xenobiotic detoxification.

AB - Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as well as of nematodes that cause lymphatic filariasis. C. quinquefasciatus is one species within the Culex pipiens species complex and can be found throughout ropical and temperate climates of the world. The ability of C. quinquefasciatus to take blood meals from birds, livestock, and humans contributes to its ability to vector pathogens between species. Here, we describe the genomic sequence of C. quinquefasciatus: Its repertoire of 18,883 protein-coding genes is 22% larger than that of Aedes aegypti and 52% larger than that of Anopheles gambiae with multiple gene-family expansions, including olfactory and gustatory receptors, salivary gland genes, and genes associated with xenobiotic detoxification.

U2 - 10.1126/science.1191864

DO - 10.1126/science.1191864

M3 - Article

SN - 0036-8075

VL - 330

SP - 86

EP - 88

JO - Science

JF - Science

IS - 6000

ER -

Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

Abstract

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