Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13

N. Hall; A. Pain; M. Berriman; C. Churcher; B. Harris; D. Harris; K. Mungall; S. Bowman; R. Atkin; S. Baker; A. Barron; K. Brooks; C. O. Buckee; C. Burrows; I. Cherevach; C. Chillingworth; T. Chillingworth; Z. Christodoulou; L. Clark; R. Clark; C. Corton; A. Cronin; R. Davies; P. Davis; P. Dear; F. Dearden; J. Doggett; T. Feltwell; A. Goble; J. Goodhead; R. Gwilliam; N. Hamlin; Z. Hance; D. Harper; H. Hauser; T. Hornsby; S. Holroyd; P. Horrocks; S. Humphray; K. Jagels; K. D. James; D. Johnson; A. Kerhornou; A. Knights; B. Konfortov; S. Kyes; N. Larke; D. Lawson; N. Lennard; A. Line; M. Maddison; J. McLean; P. Mooney; S. Moule; L. Murphy; K. Oliver; D. Ormond; C. Price; M. A. Quail; E. Rabbinowitsch; M. A. Rajandream; S. Rutter; K. M. Rutherford; M. Sanders; M. Simmonds; K. Seeger; S. Sharp; R. Smith; R. Squares; S. Squares; K. Stevens; K. Taylor; A. Tivey; L. Unwin; S. Whitehead; J. Woodward; J. E. Sulston; Alister Craig; C. Newbold; B. G. Barrell

doi:10.1038/nature01095

Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13

N. Hall
, A. Pain
, M. Berriman
, C. Churcher
, B. Harris
, D. Harris
, K. Mungall
, S. Bowman
, R. Atkin
, S. Baker
, A. Barron
, K. Brooks
, C. O. Buckee
, C. Burrows
, I. Cherevach
, C. Chillingworth
, T. Chillingworth
, Z. Christodoulou
, L. Clark
, R. Clark

C. Corton, A. Cronin, R. Davies, P. Davis, P. Dear, F. Dearden, J. Doggett, T. Feltwell, A. Goble, J. Goodhead, R. Gwilliam, N. Hamlin, Z. Hance, D. Harper, H. Hauser, T. Hornsby, S. Holroyd, P. Horrocks, S. Humphray, K. Jagels, K. D. James, D. Johnson, A. Kerhornou, A. Knights, B. Konfortov, S. Kyes, N. Larke, D. Lawson, N. Lennard, A. Line, M. Maddison, J. McLean, P. Mooney, S. Moule, L. Murphy, K. Oliver, D. Ormond, C. Price, M. A. Quail, E. Rabbinowitsch, M. A. Rajandream, S. Rutter, K. M. Rutherford, M. Sanders, M. Simmonds, K. Seeger, S. Sharp, R. Smith, R. Squares, S. Squares, K. Stevens, K. Taylor, A. Tivey, L. Unwin, S. Whitehead, J. Woodward, J. E. Sulston, Alister Craig, C. Newbold, B. G. Barrell

Biological Sciences

Wellcome Trust
Syngenta
University of Oxford
Medical Research Council

Research output: Contribution to journal › Article › peer-review

151 Citations (Scopus)

Abstract

Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum(1,2), there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3-9 and 13 of P. falciparum clone 3D7-these chromosomes account for approximately 55% of the total genome. We describe the methods used to map, sequence and annotate these chromosomes. By comparing our assemblies with the optical map, we indicate the completeness of the resulting sequence. During annotation, we assign Gene Ontology terms to the predicted gene products, and observe clustering of some malaria-specific terms to specific chromosomes. We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts.

Original language	English
Pages (from-to)	527-531
Number of pages	5
Journal	Nature
Volume	419
Issue number	6906
DOIs	https://doi.org/10.1038/nature01095
Publication status	Published - 3 Oct 2002

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10.1038/nature01095

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Hall, N., Pain, A., Berriman, M., Churcher, C., Harris, B., Harris, D., Mungall, K., Bowman, S., Atkin, R., Baker, S., Barron, A., Brooks, K., Buckee, C. O., Burrows, C., Cherevach, I., Chillingworth, C., Chillingworth, T., Christodoulou, Z., Clark, L., ... Barrell, B. G. (2002). Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature, 419(6906), 527-531. https://doi.org/10.1038/nature01095

@article{79452b3da9584f2a93674be2c61a8498,

title = "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13",

abstract = "Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum(1,2), there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3-9 and 13 of P. falciparum clone 3D7-these chromosomes account for approximately 55\% of the total genome. We describe the methods used to map, sequence and annotate these chromosomes. By comparing our assemblies with the optical map, we indicate the completeness of the resulting sequence. During annotation, we assign Gene Ontology terms to the predicted gene products, and observe clustering of some malaria-specific terms to specific chromosomes. We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts.",

author = "N. Hall and A. Pain and M. Berriman and C. Churcher and B. Harris and D. Harris and K. Mungall and S. Bowman and R. Atkin and S. Baker and A. Barron and K. Brooks and Buckee, \{C. O.\} and C. Burrows and I. Cherevach and C. Chillingworth and T. Chillingworth and Z. Christodoulou and L. Clark and R. Clark and C. Corton and A. Cronin and R. Davies and P. Davis and P. Dear and F. Dearden and J. Doggett and T. Feltwell and A. Goble and J. Goodhead and R. Gwilliam and N. Hamlin and Z. Hance and D. Harper and H. Hauser and T. Hornsby and S. Holroyd and P. Horrocks and S. Humphray and K. Jagels and James, \{K. D.\} and D. Johnson and A. Kerhornou and A. Knights and B. Konfortov and S. Kyes and N. Larke and D. Lawson and N. Lennard and A. Line and M. Maddison and J. McLean and P. Mooney and S. Moule and L. Murphy and K. Oliver and D. Ormond and C. Price and Quail, \{M. A.\} and E. Rabbinowitsch and Rajandream, \{M. A.\} and S. Rutter and Rutherford, \{K. M.\} and M. Sanders and M. Simmonds and K. Seeger and S. Sharp and R. Smith and R. Squares and S. Squares and K. Stevens and K. Taylor and A. Tivey and L. Unwin and S. Whitehead and J. Woodward and Sulston, \{J. E.\} and Alister Craig and C. Newbold and Barrell, \{B. G.\}",

year = "2002",

month = oct,

day = "3",

doi = "10.1038/nature01095",

language = "English",

volume = "419",

pages = "527--531",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "6906",

}

Hall, N, Pain, A, Berriman, M, Churcher, C, Harris, B, Harris, D, Mungall, K, Bowman, S, Atkin, R, Baker, S, Barron, A, Brooks, K, Buckee, CO, Burrows, C, Cherevach, I, Chillingworth, C, Chillingworth, T, Christodoulou, Z, Clark, L, Clark, R, Corton, C, Cronin, A, Davies, R, Davis, P, Dear, P, Dearden, F, Doggett, J, Feltwell, T, Goble, A, Goodhead, J, Gwilliam, R, Hamlin, N, Hance, Z, Harper, D, Hauser, H, Hornsby, T, Holroyd, S, Horrocks, P, Humphray, S, Jagels, K, James, KD, Johnson, D, Kerhornou, A, Knights, A, Konfortov, B, Kyes, S, Larke, N, Lawson, D, Lennard, N, Line, A, Maddison, M, McLean, J, Mooney, P, Moule, S, Murphy, L, Oliver, K, Ormond, D, Price, C, Quail, MA, Rabbinowitsch, E, Rajandream, MA, Rutter, S, Rutherford, KM, Sanders, M, Simmonds, M, Seeger, K, Sharp, S, Smith, R, Squares, R, Squares, S, Stevens, K, Taylor, K, Tivey, A, Unwin, L, Whitehead, S, Woodward, J, Sulston, JE, Craig, A, Newbold, C & Barrell, BG 2002, 'Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13', Nature, vol. 419, no. 6906, pp. 527-531. https://doi.org/10.1038/nature01095

TY - JOUR

T1 - Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13

AU - Hall, N.

AU - Pain, A.

AU - Berriman, M.

AU - Churcher, C.

AU - Harris, B.

AU - Harris, D.

AU - Mungall, K.

AU - Bowman, S.

AU - Atkin, R.

AU - Baker, S.

AU - Barron, A.

AU - Brooks, K.

AU - Buckee, C. O.

AU - Burrows, C.

AU - Cherevach, I.

AU - Chillingworth, C.

AU - Chillingworth, T.

AU - Christodoulou, Z.

AU - Clark, L.

AU - Clark, R.

AU - Corton, C.

AU - Cronin, A.

AU - Davies, R.

AU - Davis, P.

AU - Dear, P.

AU - Dearden, F.

AU - Doggett, J.

AU - Feltwell, T.

AU - Goble, A.

AU - Goodhead, J.

AU - Gwilliam, R.

AU - Hamlin, N.

AU - Hance, Z.

AU - Harper, D.

AU - Hauser, H.

AU - Hornsby, T.

AU - Holroyd, S.

AU - Horrocks, P.

AU - Humphray, S.

AU - Jagels, K.

AU - James, K. D.

AU - Johnson, D.

AU - Kerhornou, A.

AU - Knights, A.

AU - Konfortov, B.

AU - Kyes, S.

AU - Larke, N.

AU - Lawson, D.

AU - Lennard, N.

AU - Line, A.

AU - Maddison, M.

AU - McLean, J.

AU - Mooney, P.

AU - Moule, S.

AU - Murphy, L.

AU - Oliver, K.

AU - Ormond, D.

AU - Price, C.

AU - Quail, M. A.

AU - Rabbinowitsch, E.

AU - Rajandream, M. A.

AU - Rutter, S.

AU - Rutherford, K. M.

AU - Sanders, M.

AU - Simmonds, M.

AU - Seeger, K.

AU - Sharp, S.

AU - Smith, R.

AU - Squares, R.

AU - Squares, S.

AU - Stevens, K.

AU - Taylor, K.

AU - Tivey, A.

AU - Unwin, L.

AU - Whitehead, S.

AU - Woodward, J.

AU - Sulston, J. E.

AU - Craig, Alister

AU - Newbold, C.

AU - Barrell, B. G.

PY - 2002/10/3

Y1 - 2002/10/3

N2 - Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum(1,2), there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3-9 and 13 of P. falciparum clone 3D7-these chromosomes account for approximately 55% of the total genome. We describe the methods used to map, sequence and annotate these chromosomes. By comparing our assemblies with the optical map, we indicate the completeness of the resulting sequence. During annotation, we assign Gene Ontology terms to the predicted gene products, and observe clustering of some malaria-specific terms to specific chromosomes. We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts.

AB - Since the sequencing of the first two chromosomes of the malaria parasite, Plasmodium falciparum(1,2), there has been a concerted effort to sequence and assemble the entire genome of this organism. Here we report the sequence of chromosomes 1, 3-9 and 13 of P. falciparum clone 3D7-these chromosomes account for approximately 55% of the total genome. We describe the methods used to map, sequence and annotate these chromosomes. By comparing our assemblies with the optical map, we indicate the completeness of the resulting sequence. During annotation, we assign Gene Ontology terms to the predicted gene products, and observe clustering of some malaria-specific terms to specific chromosomes. We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts.

U2 - 10.1038/nature01095

DO - 10.1038/nature01095

M3 - Article

SN - 0028-0836

VL - 419

SP - 527

EP - 531

JO - Nature

JF - Nature

IS - 6906

ER -

Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13

Abstract

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