Sensitive diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis

Abena S. Amoah; Pytsje T. Hoekstra; Miriam Casacuberta-Partal; Luc E. Coffeng; Paul L.A.M. Corstjens; Beatrice Greco; Lisette van Lieshout; Mark D. Lim; Christine F. Markwalter; Maurice R. Odiere; Jutta Reinhard-Rupp; Meta Roestenberg; Russell Stothard; Louis Albert Tchuem Tchuenté; Sake J. de Vlas; Govert J. van Dam

doi:10.1016/s1473-3099(20)30254-1

Sensitive diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis

Abena S. Amoah, Pytsje T. Hoekstra, Miriam Casacuberta-Partal, Luc E. Coffeng, Paul L.A.M. Corstjens, Beatrice Greco, Lisette van Lieshout, Mark D. Lim, Christine F. Markwalter, Maurice R. Odiere, Jutta Reinhard-Rupp, Meta Roestenberg, Russell Stothard, Louis Albert Tchuem Tchuenté, Sake J. de Vlas, Govert J. van Dam

Tropical Disease Biology

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

Although preventive chemotherapy has been instrumental in reducing schistosomiasis worldwide, serious 44

challenges remain. These include the omission of certain groups from mass drug administration campaigns, the 45

existence of persistent disease hotspots as well as the risk of recrudescent infections. Central to these challenges 46

is the fact that the currently prescribed diagnostic tools to establish the burden of infection lack sensitivity, 47

especially in low endemic settings, resulting in an underestimation of the true prevalence of active Schistosoma 48

infections. This necessitates a re-evaluation and possible adaptation of current WHO-recommended control 49

strategies. Recently, more targeted interventions and novel approaches have been employed, such as 50

establishing infection burden by precision mapping to provide high resolution spatial information that delineates 51

significant variations in schistosomiasis prevalence within a defined geographical area. Such information is 52

instrumental in guiding targeted intervention campaigns. However, the need for highly accurate diagnostic tools 53

in such strategies remains a crucial factor that is often neglected. The availability of highly sensitive diagnostic 54

tests also opens up the possibility of applying sample pooling strategies, to reduce control programme costs. To 55

achieve interruption of transmission and eventually elimination of schistosomiasis, better local targeting of 56

preventive chemotherapy in combination with utilising more sensitive diagnostic tools is vital.

Original language	English
Pages (from-to)	e165-e172
Journal	The Lancet Infectious Diseases
Volume	20
Issue number	7
Early online date	4 May 2020
DOIs	https://doi.org/10.1016/s1473-3099(20)30254-1
Publication status	Published - 1 Jul 2020

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s1473-3099(20)30254-1

Amoah et al 2020 Lancet ID - CAA Vision paper (accepted version)Accepted author manuscript, 670 KB

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Amoah, A. S., Hoekstra, P. T., Casacuberta-Partal, M., Coffeng, L. E., Corstjens, P. L. A. M., Greco, B., van Lieshout, L., Lim, M. D., Markwalter, C. F., Odiere, M. R., Reinhard-Rupp, J., Roestenberg, M., Stothard, R., Tchuem Tchuenté, L. A., de Vlas, S. J., & van Dam, G. J. (2020). Sensitive diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis. The Lancet Infectious Diseases, 20(7), e165-e172. https://doi.org/10.1016/s1473-3099(20)30254-1

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title = "Sensitive diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis",

abstract = "Although preventive chemotherapy has been instrumental in reducing schistosomiasis worldwide, serious 44 challenges remain. These include the omission of certain groups from mass drug administration campaigns, the 45 existence of persistent disease hotspots as well as the risk of recrudescent infections. Central to these challenges 46 is the fact that the currently prescribed diagnostic tools to establish the burden of infection lack sensitivity, 47 especially in low endemic settings, resulting in an underestimation of the true prevalence of active Schistosoma 48 infections. This necessitates a re-evaluation and possible adaptation of current WHO-recommended control 49 strategies. Recently, more targeted interventions and novel approaches have been employed, such as 50 establishing infection burden by precision mapping to provide high resolution spatial information that delineates 51 significant variations in schistosomiasis prevalence within a defined geographical area. Such information is 52 instrumental in guiding targeted intervention campaigns. However, the need for highly accurate diagnostic tools 53 in such strategies remains a crucial factor that is often neglected. The availability of highly sensitive diagnostic 54 tests also opens up the possibility of applying sample pooling strategies, to reduce control programme costs. To 55 achieve interruption of transmission and eventually elimination of schistosomiasis, better local targeting of 56 preventive chemotherapy in combination with utilising more sensitive diagnostic tools is vital.",

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Amoah, AS, Hoekstra, PT, Casacuberta-Partal, M, Coffeng, LE, Corstjens, PLAM, Greco, B, van Lieshout, L, Lim, MD, Markwalter, CF, Odiere, MR, Reinhard-Rupp, J, Roestenberg, M, Stothard, R, Tchuem Tchuenté, LA, de Vlas, SJ & van Dam, GJ 2020, 'Sensitive diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis', The Lancet Infectious Diseases, vol. 20, no. 7, pp. e165-e172. https://doi.org/10.1016/s1473-3099(20)30254-1

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T1 - Sensitive diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis

AU - Amoah, Abena S.

AU - Hoekstra, Pytsje T.

AU - Casacuberta-Partal, Miriam

AU - Coffeng, Luc E.

AU - Corstjens, Paul L.A.M.

AU - Greco, Beatrice

AU - van Lieshout, Lisette

AU - Lim, Mark D.

AU - Markwalter, Christine F.

AU - Odiere, Maurice R.

AU - Reinhard-Rupp, Jutta

AU - Roestenberg, Meta

AU - Stothard, Russell

AU - Tchuem Tchuenté, Louis Albert

AU - de Vlas, Sake J.

AU - van Dam, Govert J.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Although preventive chemotherapy has been instrumental in reducing schistosomiasis worldwide, serious 44 challenges remain. These include the omission of certain groups from mass drug administration campaigns, the 45 existence of persistent disease hotspots as well as the risk of recrudescent infections. Central to these challenges 46 is the fact that the currently prescribed diagnostic tools to establish the burden of infection lack sensitivity, 47 especially in low endemic settings, resulting in an underestimation of the true prevalence of active Schistosoma 48 infections. This necessitates a re-evaluation and possible adaptation of current WHO-recommended control 49 strategies. Recently, more targeted interventions and novel approaches have been employed, such as 50 establishing infection burden by precision mapping to provide high resolution spatial information that delineates 51 significant variations in schistosomiasis prevalence within a defined geographical area. Such information is 52 instrumental in guiding targeted intervention campaigns. However, the need for highly accurate diagnostic tools 53 in such strategies remains a crucial factor that is often neglected. The availability of highly sensitive diagnostic 54 tests also opens up the possibility of applying sample pooling strategies, to reduce control programme costs. To 55 achieve interruption of transmission and eventually elimination of schistosomiasis, better local targeting of 56 preventive chemotherapy in combination with utilising more sensitive diagnostic tools is vital.

AB - Although preventive chemotherapy has been instrumental in reducing schistosomiasis worldwide, serious 44 challenges remain. These include the omission of certain groups from mass drug administration campaigns, the 45 existence of persistent disease hotspots as well as the risk of recrudescent infections. Central to these challenges 46 is the fact that the currently prescribed diagnostic tools to establish the burden of infection lack sensitivity, 47 especially in low endemic settings, resulting in an underestimation of the true prevalence of active Schistosoma 48 infections. This necessitates a re-evaluation and possible adaptation of current WHO-recommended control 49 strategies. Recently, more targeted interventions and novel approaches have been employed, such as 50 establishing infection burden by precision mapping to provide high resolution spatial information that delineates 51 significant variations in schistosomiasis prevalence within a defined geographical area. Such information is 52 instrumental in guiding targeted intervention campaigns. However, the need for highly accurate diagnostic tools 53 in such strategies remains a crucial factor that is often neglected. The availability of highly sensitive diagnostic 54 tests also opens up the possibility of applying sample pooling strategies, to reduce control programme costs. To 55 achieve interruption of transmission and eventually elimination of schistosomiasis, better local targeting of 56 preventive chemotherapy in combination with utilising more sensitive diagnostic tools is vital.

U2 - 10.1016/s1473-3099(20)30254-1

DO - 10.1016/s1473-3099(20)30254-1

M3 - Review article

SN - 1473-3099

VL - 20

SP - e165-e172

JO - The Lancet Infectious Diseases

JF - The Lancet Infectious Diseases

IS - 7

ER -

Sensitive diagnostic tools and targeted drug administration strategies are needed to eliminate schistosomiasis

Abstract

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