Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

Francesc Marti; James Chadwick; Richard K. Amewu; Hollie Burrell-Saward; Abhishek Srivastava; Steve Ward; Raman Sharma; Neil Berry; Paul M. O'Neill

doi:10.1039/c1md00102g

Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

Francesc Marti, James Chadwick, Richard K. Amewu, Hollie Burrell-Saward, Abhishek Srivastava, Steve Ward, Raman Sharma, Neil Berry, Paul M. O'Neill

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.

Original language	English
Pages (from-to)	661-665
Number of pages	5
Journal	RSC Medicinal Chemistry
Volume	2
Issue number	7
DOIs	https://doi.org/10.1039/c1md00102g
Publication status	Published - 1 Jul 2011

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Marti, F., Chadwick, J., Amewu, R. K., Burrell-Saward, H., Srivastava, A., Ward, S., Sharma, R., Berry, N., & O'Neill, P. M. (2011). Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities. RSC Medicinal Chemistry, 2(7), 661-665. https://doi.org/10.1039/c1md00102g

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title = "Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities",

abstract = "A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.",

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Marti, F, Chadwick, J, Amewu, RK, Burrell-Saward, H, Srivastava, A, Ward, S, Sharma, R, Berry, N & O'Neill, PM 2011, 'Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities', RSC Medicinal Chemistry, vol. 2, no. 7, pp. 661-665. https://doi.org/10.1039/c1md00102g

Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities. / Marti, Francesc; Chadwick, James; Amewu, Richard K. et al.
In: RSC Medicinal Chemistry, Vol. 2, No. 7, 01.07.2011, p. 661-665.

Research output: Contribution to journal › Article › peer-review

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AB - A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.

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