Same-day smears in the diagnosis of tuberculosis

S. Hirao; M. A. Yassin; H. G. Khamofu; L. Lawson; A. Cambanis; A. Ramsay; Luis Cuevas

doi:10.1111/j.1365-3156.2007.01952.x

Same-day smears in the diagnosis of tuberculosis

S. Hirao
, M. A. Yassin
, H. G. Khamofu
, L. Lawson
, A. Cambanis
, A. Ramsay
, Luis Cuevas

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

OBJECTIVE To assess the feasibility of completing the diagnosis of tuberculosis (TB) in 1 day by collecting only on-the-spot specimens.

METHODS Individuals with suspected TB attending district hospitals in Abuja submitted three sputum samples for routine diagnosis (the standard approach). One additional sample was collected 1 h after the first sputum (the same-day approach). One sputum sample was cultured. Blood samples were tested for HIV.

RESULTS Two hundred and twenty-four patients with chronic cough had 135/672 (20%) positive on-the-spot smears and 47/224 (21%) positive morning smears. The same-day and internationally recommended approaches identified 44 and 45 of the 78 patients with positive cultures, respectively. 106/194 (55%) patients were HIV positive. Only 9-11% of their smears were positive compared with 30-32% for HIV negatives (P < 0.01).

CONCLUSON It could be possible to diagnose TB in a single day by examining two spot specimens, but the feasibility needs to be confirmed on a larger scale.

Original language	English
Pages (from-to)	1459-1463
Number of pages	5
Journal	Tropical Medicine and International Health
Volume	12
Issue number	12
DOIs	https://doi.org/10.1111/j.1365-3156.2007.01952.x
Publication status	Published - 1 Dec 2007

Keywords

Diagnosis
HIV
Nigeria
Same day
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-3156.2007.01952.x

Cite this

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title = "Same-day smears in the diagnosis of tuberculosis",

abstract = "OBJECTIVE To assess the feasibility of completing the diagnosis of tuberculosis (TB) in 1 day by collecting only on-the-spot specimens.METHODS Individuals with suspected TB attending district hospitals in Abuja submitted three sputum samples for routine diagnosis (the standard approach). One additional sample was collected 1 h after the first sputum (the same-day approach). One sputum sample was cultured. Blood samples were tested for HIV.RESULTS Two hundred and twenty-four patients with chronic cough had 135/672 (20\%) positive on-the-spot smears and 47/224 (21\%) positive morning smears. The same-day and internationally recommended approaches identified 44 and 45 of the 78 patients with positive cultures, respectively. 106/194 (55\%) patients were HIV positive. Only 9-11\% of their smears were positive compared with 30-32\% for HIV negatives (P < 0.01).CONCLUSON It could be possible to diagnose TB in a single day by examining two spot specimens, but the feasibility needs to be confirmed on a larger scale.",

keywords = "Diagnosis, HIV, Nigeria, Same day, Tuberculosis",

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doi = "10.1111/j.1365-3156.2007.01952.x",

language = "English",

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TY - JOUR

T1 - Same-day smears in the diagnosis of tuberculosis

AU - Hirao, S.

AU - Yassin, M. A.

AU - Khamofu, H. G.

AU - Lawson, L.

AU - Cambanis, A.

AU - Ramsay, A.

AU - Cuevas, Luis

PY - 2007/12/1

Y1 - 2007/12/1

N2 - OBJECTIVE To assess the feasibility of completing the diagnosis of tuberculosis (TB) in 1 day by collecting only on-the-spot specimens.METHODS Individuals with suspected TB attending district hospitals in Abuja submitted three sputum samples for routine diagnosis (the standard approach). One additional sample was collected 1 h after the first sputum (the same-day approach). One sputum sample was cultured. Blood samples were tested for HIV.RESULTS Two hundred and twenty-four patients with chronic cough had 135/672 (20%) positive on-the-spot smears and 47/224 (21%) positive morning smears. The same-day and internationally recommended approaches identified 44 and 45 of the 78 patients with positive cultures, respectively. 106/194 (55%) patients were HIV positive. Only 9-11% of their smears were positive compared with 30-32% for HIV negatives (P < 0.01).CONCLUSON It could be possible to diagnose TB in a single day by examining two spot specimens, but the feasibility needs to be confirmed on a larger scale.

AB - OBJECTIVE To assess the feasibility of completing the diagnosis of tuberculosis (TB) in 1 day by collecting only on-the-spot specimens.METHODS Individuals with suspected TB attending district hospitals in Abuja submitted three sputum samples for routine diagnosis (the standard approach). One additional sample was collected 1 h after the first sputum (the same-day approach). One sputum sample was cultured. Blood samples were tested for HIV.RESULTS Two hundred and twenty-four patients with chronic cough had 135/672 (20%) positive on-the-spot smears and 47/224 (21%) positive morning smears. The same-day and internationally recommended approaches identified 44 and 45 of the 78 patients with positive cultures, respectively. 106/194 (55%) patients were HIV positive. Only 9-11% of their smears were positive compared with 30-32% for HIV negatives (P < 0.01).CONCLUSON It could be possible to diagnose TB in a single day by examining two spot specimens, but the feasibility needs to be confirmed on a larger scale.

KW - Diagnosis

KW - HIV

KW - Nigeria

KW - Same day

KW - Tuberculosis

U2 - 10.1111/j.1365-3156.2007.01952.x

DO - 10.1111/j.1365-3156.2007.01952.x

M3 - Article

SN - 1360-2276

VL - 12

SP - 1459

EP - 1463

JO - Tropical Medicine and International Health

JF - Tropical Medicine and International Health

IS - 12

ER -

Same-day smears in the diagnosis of tuberculosis

Abstract

Keywords

UN SDGs

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