TY - JOUR
T1 - Safe delivery of intensive care for Marburg virus disease in Rwanda
AU - Seruyange, Eric
AU - Nahayo, Ernest
AU - Uwimana, François Xavier
AU - Biramahire, Joseph
AU - Hakorimana, Fidele
AU - Nkeshimana, Menelas
AU - Turatsinze, David
AU - Bizimana, Anselme
AU - Mugabo, Hassan
AU - Burakari, Bosco
AU - Westergaard, Ryan P.
AU - Mwiseneza, Louise
AU - Niyigaba, Nicholas
AU - Sibomana, Jean Pierre
AU - Firew, Tsion
AU - Ingabire, Lambert
AU - Nyirigira, Gaston
AU - Kayigi, Etienne
AU - Mushuru, Evariste
AU - Niwemuhoza, Marie Grace
AU - Niyonizeye, Marie Grace
AU - Isingizwe, Gisele
AU - Rwibutso, Josué Bongwa
AU - Nzabana, Jean Pierre
AU - Ndayishimiye, Gentil Semahoro
AU - Ntakambirwa, Déo Kimalarungu
AU - Kazindu, Serge
AU - Ndayisabye, Halifa
AU - Remera, Eric
AU - Mutesa, Leon
AU - Rwabihama, Jean Paul
AU - Semakula, Muhammed
AU - Fowler, Robert
AU - Giuliani, Ruggero
AU - Goldberg, Jacob
AU - Jacquerioz, Frederique
AU - Diaz, Janet
AU - Rojek, Amanda
AU - Mambo, Claude M.
AU - Butera, Yvan
AU - Nsanzimana, Sabin
AU - Moreton, Elizabeth O.
AU - Fletcher, Thomas E.
AU - Fischer, William A.
AU - Twagirumugabe, Théogène
N1 - Publisher Copyright:
© 2025 Elsevier Ltd
PY - 2025/11/20
Y1 - 2025/11/20
N2 - Outbreaks of filovirus diseases, such as Marburg virus disease, present a threat to global health security, with high case-fatality rates and substantial risks of nosocomial transmission to health-care workers. However, recent advances in the delivery of optimised supportive care and pathogen-specific treatments have improved outcomes. In the third largest outbreak of Marburg virus disease (Rwanda, 2024), highly skilled medical and nursing staff provided critical care that included invasive mechanical ventilation, blood product replacement, advanced imaging, and laboratory-guided electrolyte management that led to the recovery of two critically ill patients. The delivery of intensive care in endemic settings represents an evolving paradigm shift in filovirus disease outbreak response. This Grand Round highlights the feasibility, effectiveness, and safety of intensive care management, including invasive mechanical ventilation combined with strict infection prevention and control practices in outbreaks of Marburg virus disease.
AB - Outbreaks of filovirus diseases, such as Marburg virus disease, present a threat to global health security, with high case-fatality rates and substantial risks of nosocomial transmission to health-care workers. However, recent advances in the delivery of optimised supportive care and pathogen-specific treatments have improved outcomes. In the third largest outbreak of Marburg virus disease (Rwanda, 2024), highly skilled medical and nursing staff provided critical care that included invasive mechanical ventilation, blood product replacement, advanced imaging, and laboratory-guided electrolyte management that led to the recovery of two critically ill patients. The delivery of intensive care in endemic settings represents an evolving paradigm shift in filovirus disease outbreak response. This Grand Round highlights the feasibility, effectiveness, and safety of intensive care management, including invasive mechanical ventilation combined with strict infection prevention and control practices in outbreaks of Marburg virus disease.
U2 - 10.1016/S1473-3099(25)00466-9
DO - 10.1016/S1473-3099(25)00466-9
M3 - Review article
C2 - 41175885
AN - SCOPUS:105020806835
SN - 1473-3099
VL - 26
SP - e248-e255
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
IS - 5
ER -
SDG 3 Good Health and Well-being