Role of lysozymes of anopheles mosquitoes in plasmodium development

Clelia Oliva; Luca Facchinelli; Nicoletta Basilico; Roberta Spaccapelo

doi:10.1007/978-3-319-09432-8_4

Role of lysozymes of anopheles mosquitoes in plasmodium development

Clelia Oliva, Luca Facchinelli, Nicoletta Basilico, Roberta Spaccapelo

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Lysozymes are important regulators of the immune system in most organisms. These enzymes can show a direct bactericidal activity or upregulate the signaling cascades that result in the production of antimicrobial peptides. In mosquitoes and particularly in the malaria–vector species of the genus Anopheles, lysozymes are present in different tissues and developmental stage expression profiles and are involved in the innate immunity and digestion of bacteria. In An. gambiae, lysozyme C1 protects the oocysts from melanization, thus contributing to an increased prevalence and intensity of Plasmodium berghei infection. The role and importance of lysozymes in the mosquito and in the regulation of oocysts development and the mechanism of action are still unclear.

Original language	English
Title of host publication	Human and Mosquito Lysozymes: Old Molecules for New Approaches Against Malaria
Pages	59-65
Number of pages	7
ISBN (Electronic)	9783319094328
DOIs	https://doi.org/10.1007/978-3-319-09432-8_4
Publication status	Published - 1 Jan 2015
Externally published	Yes

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10.1007/978-3-319-09432-8_4

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abstract = "Lysozymes are important regulators of the immune system in most organisms. These enzymes can show a direct bactericidal activity or upregulate the signaling cascades that result in the production of antimicrobial peptides. In mosquitoes and particularly in the malaria–vector species of the genus Anopheles, lysozymes are present in different tissues and developmental stage expression profiles and are involved in the innate immunity and digestion of bacteria. In An. gambiae, lysozyme C1 protects the oocysts from melanization, thus contributing to an increased prevalence and intensity of Plasmodium berghei infection. The role and importance of lysozymes in the mosquito and in the regulation of oocysts development and the mechanism of action are still unclear.",

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AU - Oliva, Clelia

AU - Facchinelli, Luca

AU - Basilico, Nicoletta

AU - Spaccapelo, Roberta

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Lysozymes are important regulators of the immune system in most organisms. These enzymes can show a direct bactericidal activity or upregulate the signaling cascades that result in the production of antimicrobial peptides. In mosquitoes and particularly in the malaria–vector species of the genus Anopheles, lysozymes are present in different tissues and developmental stage expression profiles and are involved in the innate immunity and digestion of bacteria. In An. gambiae, lysozyme C1 protects the oocysts from melanization, thus contributing to an increased prevalence and intensity of Plasmodium berghei infection. The role and importance of lysozymes in the mosquito and in the regulation of oocysts development and the mechanism of action are still unclear.

AB - Lysozymes are important regulators of the immune system in most organisms. These enzymes can show a direct bactericidal activity or upregulate the signaling cascades that result in the production of antimicrobial peptides. In mosquitoes and particularly in the malaria–vector species of the genus Anopheles, lysozymes are present in different tissues and developmental stage expression profiles and are involved in the innate immunity and digestion of bacteria. In An. gambiae, lysozyme C1 protects the oocysts from melanization, thus contributing to an increased prevalence and intensity of Plasmodium berghei infection. The role and importance of lysozymes in the mosquito and in the regulation of oocysts development and the mechanism of action are still unclear.

U2 - 10.1007/978-3-319-09432-8_4

DO - 10.1007/978-3-319-09432-8_4

M3 - Chapter

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SP - 59

EP - 65

BT - Human and Mosquito Lysozymes: Old Molecules for New Approaches Against Malaria

ER -

Role of lysozymes of anopheles mosquitoes in plasmodium development

Abstract

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