Risk of dengue in Central Africa: Vector competence studies with Aedes aegypti and Aedes albopictus (Diptera: Culicidae) populations and dengue 2 virus.

Basile Kamgang; Marie Vazeille; Armel N. Tedjou; Theodel A. Wilson-Bahun; Aurélie P. Yougang; Laurence Mousson; Charles Wondji; Anna Bella Failloux

doi:10.1371/journal.pntd.0007985

Risk of dengue in Central Africa: Vector competence studies with Aedes aegypti and Aedes albopictus (Diptera: Culicidae) populations and dengue 2 virus.

Basile Kamgang, Marie Vazeille, Armel N. Tedjou, Theodel A. Wilson-Bahun, Aurélie P. Yougang, Laurence Mousson, Charles Wondji, Anna Bella Failloux

Vector Biology

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

IIntroduction

Dengue is the most important mosquito-borne diseases worldwide but was considered scarce in West-Central Africa. During the last decade, dengue outbreaks have increasingly been reported in urban foci in this region suggesting major epidemiological changes. However, in Central Africa where both vectors, Aedes aegypti and Aedes albopictus are well established, the role of each species in dengue transmission remains poorly investigated.

Methodology/Principal findings

Field-collected strains of Ae. aegypti and Ae. albopictus from different ecological settings in Central Africa were experimentally challenged with dengue 2 virus (DENV-2). Mosquitoes were analysed at 14- and 21-days post-infection. Analysis provide evidence that both Ae. aegypti and Ae. albopictus in Central Africa were able to transmit dengue virus with Ae. aegypti exhibiting a higher transmission rate. Unexpectedly, two Ae. aegypti populations from Bénoué and Maroua, in northern Cameroon, were not able to transmit DENV-2.

Conclusions/Significance

We conclude that both Ae. aegypti and Ae. albopictus are susceptible to DENV-2 and may intervene as active dengue vectors. These findings highlight the urgent need to plan a vector surveillance program and control methods against dengue vectors in Central Africa in order to prevent future outbreaks.

Original language	English
Article number	e0007985
Pages (from-to)	1-12
Number of pages	12
Journal	PLoS Neglected Tropical Diseases
Volume	13
Issue number	12
DOIs	https://doi.org/10.1371/journal.pntd.0007985
Publication status	Published - 30 Dec 2019

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10.1371/journal.pntd.0007985Licence: CC BY

Kamgang et alAccepted author manuscript, 32 KBLicence: CC BY

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Kamgang, B., Vazeille, M., Tedjou, A. N., Wilson-Bahun, T. A., Yougang, A. P., Mousson, L., Wondji, C., & Failloux, A. B. (2019). Risk of dengue in Central Africa: Vector competence studies with Aedes aegypti and Aedes albopictus (Diptera: Culicidae) populations and dengue 2 virus. PLoS Neglected Tropical Diseases, 13(12), 1-12. Article e0007985. https://doi.org/10.1371/journal.pntd.0007985

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title = "Risk of dengue in Central Africa: Vector competence studies with Aedes aegypti and Aedes albopictus (Diptera: Culicidae) populations and dengue 2 virus.",

abstract = "IIntroductionDengue is the most important mosquito-borne diseases worldwide but was considered scarce in West-Central Africa. During the last decade, dengue outbreaks have increasingly been reported in urban foci in this region suggesting major epidemiological changes. However, in Central Africa where both vectors, Aedes aegypti and Aedes albopictus are well established, the role of each species in dengue transmission remains poorly investigated.Methodology/Principal findingsField-collected strains of Ae. aegypti and Ae. albopictus from different ecological settings in Central Africa were experimentally challenged with dengue 2 virus (DENV-2). Mosquitoes were analysed at 14- and 21-days post-infection. Analysis provide evidence that both Ae. aegypti and Ae. albopictus in Central Africa were able to transmit dengue virus with Ae. aegypti exhibiting a higher transmission rate. Unexpectedly, two Ae. aegypti populations from B{\'e}nou{\'e} and Maroua, in northern Cameroon, were not able to transmit DENV-2.Conclusions/SignificanceWe conclude that both Ae. aegypti and Ae. albopictus are susceptible to DENV-2 and may intervene as active dengue vectors. These findings highlight the urgent need to plan a vector surveillance program and control methods against dengue vectors in Central Africa in order to prevent future outbreaks.",

author = "Basile Kamgang and Marie Vazeille and Tedjou, \{Armel N.\} and Wilson-Bahun, \{Theodel A.\} and Yougang, \{Aur{\'e}lie P.\} and Laurence Mousson and Charles Wondji and Failloux, \{Anna Bella\}",

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Kamgang, B, Vazeille, M, Tedjou, AN, Wilson-Bahun, TA, Yougang, AP, Mousson, L, Wondji, C & Failloux, AB 2019, 'Risk of dengue in Central Africa: Vector competence studies with Aedes aegypti and Aedes albopictus (Diptera: Culicidae) populations and dengue 2 virus.', PLoS Neglected Tropical Diseases, vol. 13, no. 12, e0007985, pp. 1-12. https://doi.org/10.1371/journal.pntd.0007985

TY - JOUR

T1 - Risk of dengue in Central Africa: Vector competence studies with Aedes aegypti and Aedes albopictus (Diptera: Culicidae) populations and dengue 2 virus.

AU - Kamgang, Basile

AU - Vazeille, Marie

AU - Tedjou, Armel N.

AU - Wilson-Bahun, Theodel A.

AU - Yougang, Aurélie P.

AU - Mousson, Laurence

AU - Wondji, Charles

AU - Failloux, Anna Bella

PY - 2019/12/30

Y1 - 2019/12/30

N2 - IIntroductionDengue is the most important mosquito-borne diseases worldwide but was considered scarce in West-Central Africa. During the last decade, dengue outbreaks have increasingly been reported in urban foci in this region suggesting major epidemiological changes. However, in Central Africa where both vectors, Aedes aegypti and Aedes albopictus are well established, the role of each species in dengue transmission remains poorly investigated.Methodology/Principal findingsField-collected strains of Ae. aegypti and Ae. albopictus from different ecological settings in Central Africa were experimentally challenged with dengue 2 virus (DENV-2). Mosquitoes were analysed at 14- and 21-days post-infection. Analysis provide evidence that both Ae. aegypti and Ae. albopictus in Central Africa were able to transmit dengue virus with Ae. aegypti exhibiting a higher transmission rate. Unexpectedly, two Ae. aegypti populations from Bénoué and Maroua, in northern Cameroon, were not able to transmit DENV-2.Conclusions/SignificanceWe conclude that both Ae. aegypti and Ae. albopictus are susceptible to DENV-2 and may intervene as active dengue vectors. These findings highlight the urgent need to plan a vector surveillance program and control methods against dengue vectors in Central Africa in order to prevent future outbreaks.

AB - IIntroductionDengue is the most important mosquito-borne diseases worldwide but was considered scarce in West-Central Africa. During the last decade, dengue outbreaks have increasingly been reported in urban foci in this region suggesting major epidemiological changes. However, in Central Africa where both vectors, Aedes aegypti and Aedes albopictus are well established, the role of each species in dengue transmission remains poorly investigated.Methodology/Principal findingsField-collected strains of Ae. aegypti and Ae. albopictus from different ecological settings in Central Africa were experimentally challenged with dengue 2 virus (DENV-2). Mosquitoes were analysed at 14- and 21-days post-infection. Analysis provide evidence that both Ae. aegypti and Ae. albopictus in Central Africa were able to transmit dengue virus with Ae. aegypti exhibiting a higher transmission rate. Unexpectedly, two Ae. aegypti populations from Bénoué and Maroua, in northern Cameroon, were not able to transmit DENV-2.Conclusions/SignificanceWe conclude that both Ae. aegypti and Ae. albopictus are susceptible to DENV-2 and may intervene as active dengue vectors. These findings highlight the urgent need to plan a vector surveillance program and control methods against dengue vectors in Central Africa in order to prevent future outbreaks.

U2 - 10.1371/journal.pntd.0007985

DO - 10.1371/journal.pntd.0007985

M3 - Article

SN - 1935-2727

VL - 13

SP - 1

EP - 12

JO - PLoS Neglected Tropical Diseases

JF - PLoS Neglected Tropical Diseases

IS - 12

M1 - e0007985

ER -

Risk of dengue in Central Africa: Vector competence studies with Aedes aegypti and Aedes albopictus (Diptera: Culicidae) populations and dengue 2 virus.

Abstract

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