Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil

DW Fawkner-Corbett; SK Khoo; MC Duarte; PGM Bezerra; YA Bochkov; JE Gern; PN Le Souef; PS McNamara; K Rose; AM Fonceca; M Hopkins; M Britto; Luis Cuevas; JB Correia

doi:10.1002/jmv.24300

Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil

DW Fawkner-Corbett
, SK Khoo
, MC Duarte
, PGM Bezerra
, YA Bochkov
, JE Gern
, PN Le Souef
, PS McNamara
, K Rose
, AM Fonceca
, M Hopkins
, M Britto
, Luis Cuevas
, JB Correia

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Introduction

Human rhinovirus (RV) is a common cause of acute respiratory infection (ARI) in children. We aimed to characterise the clinical and demographic features associated with different RV species detected in children attending hospital with ARI, from low-income families in North-east Brazil.

Methods

Nasopharyngeal aspirates were collected from 630 children <5years with ARI. Clinical diagnosis and disease severity were also recorded. Samples were analysed by multiplex PCR for 18 viral and atypical bacterial pathogens; RV positive samples underwent partial sequencing to determine species and type.

Results

RV was the fourth commonest pathogen accounting for 18.7% of pathogens detected. RV was commonly detected in children with bronchiolitis, pneumonia and asthma/episodic viral wheeze (EVW). Species and type were assigned in 112 cases (73% RV-A; 27% RV-C; 0% RV-B). Generally, there were no differences in clinical or demographic characteristics between those infected with RV-A and RV-C. However, in children with asthma/EVW, RV-C was detected relatively more frequently than RV-A (23% vs 5%; p = 0.04).

Conclusions

Our findings highlight RV as a potentially important pathogen in this setting. Generally, clinical and demographic features were similar in children in whom RV A and C species were detected. However, RV-C was more frequently found in children with asthma/EVW than RV-A. This article is protected by copyright. All rights reserved

Original language	English
Pages (from-to)	58-63
Number of pages	6
Journal	Journal of Medical Virology
Volume	88
Issue number	1
DOIs	https://doi.org/10.1002/jmv.24300
Publication status	Published - 22 Jun 2015

Keywords

Asthma
Bronchiolitis
Child
Pneumonia
Respiratory tract infections
Rhinovirus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.24300

Cite this

Fawkner-Corbett, DW., Khoo, SK., Duarte, MC., Bezerra, PGM., Bochkov, YA., Gern, JE., Le Souef, PN., McNamara, PS., Rose, K., Fonceca, AM., Hopkins, M., Britto, M., Cuevas, L., & Correia, JB. (2015). Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil. Journal of Medical Virology, 88(1), 58-63. https://doi.org/10.1002/jmv.24300

@article{ba16f20ff72340659674454afce0e92b,

title = "Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil",

abstract = "IntroductionHuman rhinovirus (RV) is a common cause of acute respiratory infection (ARI) in children. We aimed to characterise the clinical and demographic features associated with different RV species detected in children attending hospital with ARI, from low-income families in North-east Brazil.MethodsNasopharyngeal aspirates were collected from 630 children <5years with ARI. Clinical diagnosis and disease severity were also recorded. Samples were analysed by multiplex PCR for 18 viral and atypical bacterial pathogens; RV positive samples underwent partial sequencing to determine species and type.ResultsRV was the fourth commonest pathogen accounting for 18.7\% of pathogens detected. RV was commonly detected in children with bronchiolitis, pneumonia and asthma/episodic viral wheeze (EVW). Species and type were assigned in 112 cases (73\% RV-A; 27\% RV-C; 0\% RV-B). Generally, there were no differences in clinical or demographic characteristics between those infected with RV-A and RV-C. However, in children with asthma/EVW, RV-C was detected relatively more frequently than RV-A (23\% vs 5\%; p = 0.04).ConclusionsOur findings highlight RV as a potentially important pathogen in this setting. Generally, clinical and demographic features were similar in children in whom RV A and C species were detected. However, RV-C was more frequently found in children with asthma/EVW than RV-A. This article is protected by copyright. All rights reserved",

keywords = "Asthma, Bronchiolitis, Child, Pneumonia, Respiratory tract infections, Rhinovirus",

author = "DW Fawkner-Corbett and SK Khoo and MC Duarte and PGM Bezerra and YA Bochkov and JE Gern and \{Le Souef\}, PN and PS McNamara and K Rose and AM Fonceca and M Hopkins and M Britto and Luis Cuevas and JB Correia",

year = "2015",

month = jun,

day = "22",

doi = "10.1002/jmv.24300",

language = "English",

volume = "88",

pages = "58--63",

journal = "Journal of Medical Virology",

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Fawkner-Corbett, DW, Khoo, SK, Duarte, MC, Bezerra, PGM, Bochkov, YA, Gern, JE, Le Souef, PN, McNamara, PS, Rose, K, Fonceca, AM, Hopkins, M, Britto, M, Cuevas, L & Correia, JB 2015, 'Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil', Journal of Medical Virology, vol. 88, no. 1, pp. 58-63. https://doi.org/10.1002/jmv.24300

TY - JOUR

T1 - Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil

AU - Fawkner-Corbett, DW

AU - Khoo, SK

AU - Duarte, MC

AU - Bezerra, PGM

AU - Bochkov, YA

AU - Gern, JE

AU - Le Souef, PN

AU - McNamara, PS

AU - Rose, K

AU - Fonceca, AM

AU - Hopkins, M

AU - Britto, M

AU - Cuevas, Luis

AU - Correia, JB

PY - 2015/6/22

Y1 - 2015/6/22

N2 - IntroductionHuman rhinovirus (RV) is a common cause of acute respiratory infection (ARI) in children. We aimed to characterise the clinical and demographic features associated with different RV species detected in children attending hospital with ARI, from low-income families in North-east Brazil.MethodsNasopharyngeal aspirates were collected from 630 children <5years with ARI. Clinical diagnosis and disease severity were also recorded. Samples were analysed by multiplex PCR for 18 viral and atypical bacterial pathogens; RV positive samples underwent partial sequencing to determine species and type.ResultsRV was the fourth commonest pathogen accounting for 18.7% of pathogens detected. RV was commonly detected in children with bronchiolitis, pneumonia and asthma/episodic viral wheeze (EVW). Species and type were assigned in 112 cases (73% RV-A; 27% RV-C; 0% RV-B). Generally, there were no differences in clinical or demographic characteristics between those infected with RV-A and RV-C. However, in children with asthma/EVW, RV-C was detected relatively more frequently than RV-A (23% vs 5%; p = 0.04).ConclusionsOur findings highlight RV as a potentially important pathogen in this setting. Generally, clinical and demographic features were similar in children in whom RV A and C species were detected. However, RV-C was more frequently found in children with asthma/EVW than RV-A. This article is protected by copyright. All rights reserved

AB - IntroductionHuman rhinovirus (RV) is a common cause of acute respiratory infection (ARI) in children. We aimed to characterise the clinical and demographic features associated with different RV species detected in children attending hospital with ARI, from low-income families in North-east Brazil.MethodsNasopharyngeal aspirates were collected from 630 children <5years with ARI. Clinical diagnosis and disease severity were also recorded. Samples were analysed by multiplex PCR for 18 viral and atypical bacterial pathogens; RV positive samples underwent partial sequencing to determine species and type.ResultsRV was the fourth commonest pathogen accounting for 18.7% of pathogens detected. RV was commonly detected in children with bronchiolitis, pneumonia and asthma/episodic viral wheeze (EVW). Species and type were assigned in 112 cases (73% RV-A; 27% RV-C; 0% RV-B). Generally, there were no differences in clinical or demographic characteristics between those infected with RV-A and RV-C. However, in children with asthma/EVW, RV-C was detected relatively more frequently than RV-A (23% vs 5%; p = 0.04).ConclusionsOur findings highlight RV as a potentially important pathogen in this setting. Generally, clinical and demographic features were similar in children in whom RV A and C species were detected. However, RV-C was more frequently found in children with asthma/EVW than RV-A. This article is protected by copyright. All rights reserved

KW - Asthma

KW - Bronchiolitis

KW - Child

KW - Pneumonia

KW - Respiratory tract infections

KW - Rhinovirus

U2 - 10.1002/jmv.24300

DO - 10.1002/jmv.24300

M3 - Article

SN - 0146-6615

VL - 88

SP - 58

EP - 63

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 1

ER -

Rhinovirus-C detection in children presenting with acute respiratory infection to hospital in Brazil

Abstract

Keywords

UN SDGs

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